GI Immunology Flashcards
LO1: Th1 (4)
1) Make IFN-gamma
2) Activate M1 (angry Macrophages)
3) Make IL-2
4) Activate CTL
LO1: Th17 (4)
1) Important for resistance to more difficult organisms
2) Make IL-17
3) IL-23 pushes them to become Th17
4) Like Th1’s from hell. Implicated in psoriasis
Th2 (3)
1) Make IL-4
2) Activates M2 macrophages-wall off and heal
3) IL-4 also attracts eosinophils
Tfh (2)
1) Stimulated by antigen
2) Migrate to B cell follicles to help B cells get activated and produce IgM, IgG, IgE, IgA
Treg(3)
1) Make IL-10 and TGF-beta
2) Supress other T cells to keep immune system in check
3) Predominant T helper
CTL
1) Destroy body cells with foreing material or abnl antigen on the surface-presented by Class I MHC
2) Also make IFN-gamma to attract macrophages to eat cells
LO2: Peyer’s Patch Nl conditions (3)
1) Abundant TGF-beta favors Th0->Treg
2) DC make IL-10 favoring Tregs
3) Tfh also drive activation of B cells keeping mucus layer close to sterile
LO2: Peyer’s Patch Inflamm conditions
1) IL-6 is produced by epithelia and other cells in response to stress or damage
2) TGF-beta and IL-6 downregulate Tregs and upregulate other T cells
LO3: genetic and environmental contributors to IBD and celiac
1) Treg in gut=iTreg (induced)-prevent chronic inflammation of Th1/2/17 recognizing commensal bacteria
2) When knocked out in mice IBD results
LO4: HLA allele and IBD and autoimmune
1) HLA-DQ2 and HLA-DQ-8 are Class II MHC connected to Celiac
2) TTG2 Ab in Celiac can result in dermatitis herpetiformis ue to cross rxn w/ skin TTG3
3) Celiac not autoimmune, dermatitis herpetiformis is
LO5: Non-celiac gluten sensitivity dx (4)
1) Neg blood test for Celiac and no damage on intestinal biopsy
2) Symptom improve w/o gluten
3) Symptom recurrence w gluten
4) No other explanation
Non-celiac gluten sensitivity and FODMAPS
Fermented Oligosaccharides Disaccharides Monosaccharides and Polyols
