GI CIS/DSA Flashcards

1
Q
Definitions:
Acholic
Anorexia
Acute abdomen
Borborygmi
Cachexia
A

Acholic: acholic stools are white clay colored stools, which result from absence of secretion of bile into the GI tract

Anorexia: lack of appetite

Acute abdomen: any serious acute intraabdominal condition attended by pain, tenderness, and muscular rigidity and for which emergency surgery must be considered

Borborygmi: a rumbling noise caused by propulsion of gas through the intestines

Cachexia: a profound and marked state of constitutional disorder; general ill health and malnutrition

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2
Q
Definitions:
Cholestasis
Coffee ground emesis
Colic
Courvoisiers Sign
Cullen sign
A

Cholestasis: stoppage or suppression of bile flow, due to factors within (intrahepatic cholestasis) or outside the liver (extrahepatic cholestasis)

Coffee ground emesis: denotes blood congealed and separated within gastric contents that takes the form of coffee grounds when in contact with acidic environment

Colic: acute paroxysmal abdominal pain

Courvoisiers sign: Enlarged non-tender gallbladder secondary to pancreatic disease or cancer

Cullen sign: Ecchymosis around the umbillicus secondary to hemorrhage

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3
Q
Definitions:
Curling ulcer
Cushing ulcer
Dyspepsia
Dysphagia
Dysplasia
A

Curling ulcer: stress ulcer is a peptic ulcer of the duodenum in a patient with extensive superficial burns

Cushing ulcer: stress ulcer is a peptic ulcer occuring from severe head injury or with other lesions of the central nervous system

Dyspepsia: postprandial epigastric discomfort

Dysphagia: difficulty swallowing

Dysplasia: abnormal tissue development, alteration in size, shape, and organization of cells

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4
Q
Definitions:
Edentulous
Esophagitis
ERCP
Eructation
EUS
A

Edentulous: having no teeth

Esophagitis: inflammation of the esophagus

ERCP: Endoscopic retrograde cholangiopancreatography

Eructation: expulsion of swallowed air, aka buroing

EUS: Endoscopic ultrasound

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5
Q
Definitions: 
Flatus
Gastritis
Gastropathy
GGT
Grey turner sign
Globus pharyngeus
Gaurding
Heel strike
A

Flatus: gas or air in the GI tract expelled through the anus

Gastritis: inflammation of the stomach with distinctive histologic and endoscopic features

Gastropathy: gastric conditions where there is epithelial or endothelial damage without inflammation

GGT: gamma glutamyl transferase, used to determine the cause of elevated alkaline phosphatase (ALP)

  • both elevated = liver disease
  • ALP elevated but not GGT = other (usually bone)

Grey turner sign: Flank ecchymosis secondary to hemorrhage

Globus pharyndeus: also known as globus hystericus which is a foreign body sensation lovalized in the neck that does not interfere with swallowing and sometimes is relieved by swallowing
-often occurs in the setting of anxiety or OCD, often attributed to GERD

Gaurding: protective response in muscle resulting from pain or fear of movement, voluntary versus involuntary

Heel strike: Patient supine, Doc strikes patients heel. pain upon striking could indicate appendicitis

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6
Q
Definitions: 
Hematemesis
Hematochezia
Icterus/jaundice
Iliopsoas Muscle test
KUB Xray
A

Hematemesis: Vomiting blood

Hematochezia: passage of bright red blood or marron stools

icterus/jaundice: yellowish staining of the integument, sclera, and deeper tissues

Iliopsoas muscle test: have the patient flex their hip against your resistance - increased abdominal pain is a positive test
-suggests irritation of the psoas muscle from inflammation of the appendix

KUB Xray: plain abdominal x-ray of the kidney Ureters and bladder

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7
Q
Definitions:
LGIB
Llyods punch/CVA tenderness
McBurneys Point
Melena
Mittleschmerz
A

LGIB: Lower gastrointestinal bleeding

Llyods punch/CVA tenderness: gently tapping the area of the back overlying the kidney produces pain
-suggests an infecttion around the kidney or a renal stone

McBurneys Point: Rebound tenderness or pain 1/3 of the distance from the ASIS to the umbilicus that may suggest appendicitis or peritoneal irritation

Melena: dark colored stool consistent with broken down hemosiderin in bowel, typically malodorous sticky and thick like paste (Tarry)

Mittleschmerz: lower abdominal pain in the middle of the mestrual cycle, doesnt cause rebound tenderness

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8
Q
Definitions: 
MRCP
Murphy sign
Nausea
Obstipation
Obturator muscle test
Odynophagia
A

MRCP: Magnetic resonance cholangiopancreatography

Murphy sign: Palpate deeply under right costal margin during inspiration and observe for pain and or sudden stop in inspiratory effort
-test for cholecystitis or cholelithiasis

Nausea: subjective sensation of impending urge to vomit

Obstipation: severe intractable constipation caused by intestinal obstruction

Obturatior muscle test: Flex the patients right thigh at the hip, with the knee bent and rotate the leg internally at the hip. Right hypogastric pain is a positive test
-this suggests irriation of the obturator muscle from an inflamed appendix

Odynophagia: painful swallowing

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9
Q
Definitions: 
Pneumobilia
Pneumomediastinum
Pneumoperitoneum
Psoas sign
Pyrosis
A

Pneumobilia: abnormal presence of gas in the biliary system/bile ducts

Pneumomediastinum: abnormal presence of air or gas in the mediastinum, may interfere with respiration and circulation, may lead to pneumothorax or pneumopericardium, occur spontaneously or as a result of trauma or pathology or after diagnostic procedure

Pneumoperitoneum: abnormal presence of air in the peritoneal cavity

Psoas sign: associated with retrocecal appendix. Maifested by RLQ pain with passive right hip extension

Pyrosis: substernal burning sensation aka heartburn

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10
Q
Definitions:
Rebound tenderness
Regurgitation
Reetching
Rovsings sign
Steatorrhea
Tenesmus
UGIB
Ulcer
Ureterolithiasis
Virchows node
Vomiting/emesis
A

Rebound tenderness: pain upon removal of pressure, rather than the application of pressure in the abdome. Tests for peritoneal inflammation/acute abdomen

Regurgitation: effortless reflux of liquid or gastric or esophageal food contents in the absence of N/V

Retching: peristalsis of stomach and esophagus conducted with a closed glottis

Rigidity: like it sounds, abdomen is hard, involuntary reflex contraction of abdominal wall

Rovsings sign: Pain in the RLQ during left-sided pressure- referred rebound tenderness seen in appendicitis

Steatorrhea: fatty greasy stools

Tenesmus ineffectual and painful straining at stool (or urination)

UGIB: upper gastrointestinal bleeding

Ulcer: local defect or excavation of the surface of an organ or tissue that is produced by the sloughing (shedding) of inflammed necrotic tissue

Ureterolithiasis: stone from kidney making its way through ureter to bladder, urine analysis will show hematuria

Virchows Node: Palpable mass, lymph node, in the left supraclavicular/sternoclavicular fossa

Vomiting emesis: Queasiness to retching, forceful ejection of upper gut contents from the mouth

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11
Q

what is a list of Red Flag symptoms and signs?

A
Dysphagia
Odynophagia
Hematemesis
Melena
Unintentional weight loss
Persistent vomiting
Constant/severe pain
Unexplained iron deficiency anemia
palpable mass
Lymphadenopathy
Family history of upper gastrointestinal cancer
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12
Q

Common disease found in the RUQ?

A
Cholecystitis
Pyelonephritis
Ureteric colic
Hepatitis
Pneumonia

Gall bladder!

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13
Q

Common diseases found in RLQ?

A
Appendicitis
Ureteric colic
Inguinal hernia
IBD
UTI
Gynaecological
Testicular torsion
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14
Q

Common diseases found in the LUQ

A
Gastric ulcer
Pyelonephritis
Ureteric colic
Pneumonia
PUD (peptic ulcer disease)
Gastritis
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15
Q

common disease found in the LLQ

A
Diverticulitis
Ureteric colic
Inguinial hernia
Gynaecological
Testicular torsion
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16
Q

common diseases found in the epigastric region?

A
Peptic ulcer disease
cholecystitis
Pancreatitis
Mycocardial infarction
food poisoning
Biliary tract disease
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17
Q

common diseases found in the Peri umbilical region

A

Small bowel obstruction
Large bowel obstruction
Appendicitis
Abdominal aortic aneursym

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18
Q

what is a differential diagnosis for a Upper GI bleed?

A
Peptic ulcer disease
Erosice gastritis
Arteriovenous malformations/angioectasias
Mallory-weiss tear
Esophageal varices
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19
Q

difference between visceral pain and parietal pain

A

Visceral pain:

  • visceral pain fibers
  • secondary to distention, stretching or contraction of hollow organs
  • felt in midline at the level of the structure involved
  • not localized

Parietal pain:

  • somatic nerve fibers
  • secondary to inflammation in the parietal peritoneum
  • constant more severe
  • localized
  • aggrevated by movement or coughing
  • alleviated by remaining still
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20
Q

what are important historical elements for Nausea and vomiting and what are the main big triggers for these?

A

Important historical findings:

  • apperance
  • blood
  • coffee grounds
  • food
  • feculent
  • how often
  • projectile

main causes:

  • visceral afferent stimulation
  • vestibular disorders
  • CNS disorders
  • irritation of chemoreceptor trigger zone
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21
Q

Main causes of oropharyngeal dysphagia

A

Trouble initiating swallowing:

  • Neurological disorders
  • Muscular and rheumatologic disorders
  • metabolic disorders
  • infectious disease
  • structural disorders
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22
Q

Main causes of esophageal dysphagia

A

Mechaincal obstruction:

  • schatzu ring
  • peptic structure
  • esophageal cancer
  • eosinophilic esophagitis

Motillity disorder:

  • achalasia
  • diffuse esophageal spasm
  • scleroderma
  • ineffective esophageal motillity
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23
Q

What is CBC and what is it if it has Diff?

A

CBC would contain:

  • white blood count (WBC)
  • Hemoglobin
  • hematocrit
  • Mean corpuscular volume (MCV)
  • Mean corpuscular hemoglobin (MCH)
  • Mean corpuscular hemoglobin concentration (MCHC)
  • Red cell distribution width (RDW)
  • Platelet count (RBC)
  • Red cell count

with diff: includs all above and

  • Percentage and absolute differential counts of
  • PMN
  • Lymph
  • Baso
  • Eos
  • Mono
  • Neut
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24
Q

what is in a BMP and what is added in a CMP

A

Basic metabolic panel:

  • Sodium
  • Potassium
  • Chloride
  • Carbon dioxide (bicarb)
  • BUN
  • Creatine
  • Glucose
  • calcium
  • eGFR calculation
  • BUN:creatine ratio

Comprehensive metabolic panel is everything in a BMP plus:

  • Albumin:globulin (A:G) ratio
  • Albumin
  • Alkaline phosphatase
  • Aspartate aminotransferase (AST/SGOT)
  • Alanine aminotransferase (ALT/SGPT)
  • Bilirubin total
  • Globulin total
  • Protein total
25
Q

What GI labs to consider when looking at the pancreas?

A

Lipase

Amylase (better one)

26
Q

what GI labs to consider when looking at the liver?

A
  • Gamma-glutamyl transferase (GGT)
  • Fractionate bilirubin
  • PT/INR (helpful to know bleeding risk prior to procedure)
27
Q

what GI labs to consider when looking for zolinger ellison gastrinoma?

A

Fasting Gastrin

-secretion stimulation test (will be elevated)

28
Q

What are the two types of Plain films for the abdomen and what are they good at screening for?

A

Acute abdominal series:

  • consists of a single view chest x-ray and a flat and upright x-ray of the abdomen
  • good for inital screening
  • not diagonstic in most cases
  • great to check quickly for free air, bowel obstruction, and or constipation

KUB:

  • single flat plate (supine) x-ray of the abdomen
  • limited diagnostic benefit
29
Q

what is Barium Esophagography and what is it used for

A

aka Barium swallow x-ray

Differentiate between mechanical lesions and motillity disorders

Barium study is more sensitive for detecting subtle esophageal narrowing due to rings, achalasia, and proximal esophageal lesions

30
Q

what is Esophagogastroduodenoscopy and what is it used for?

A

Studty of choice: upper endoscopy

  • persistent heart burn
  • dysphagia
  • odynophagia
  • structural abnormalities detected on barium esophagography

Diagnostic and therapeutic:

  • direct visualization
  • allows biopsy of mucosal abnormalities and of normal apperaing mucosa
  • allows for dilation of strictures
31
Q

wha is colonoscopy used for?

A

Screening tests

Lower GI bleeds

Undifferentiated LAP

32
Q

What is Ultrasound used for?

A

Good for imaging fluid filled structures

  • gall bladder
  • fast scan for trauma
  • bladder
  • kidneys
  • aorta and vessels
  • heart

Limited by air and fat

33
Q

How do we visualize the biliary tree?

A

ERCP: endoscopic retrograde cholangiopancreatography
-diagnostic and therapeutic technique

MRCP: magnetic resonance cholangiopancreatography

HIDA: hepatobilary iminodiacetic acid scan
-useful in determing the amount of bile in biliary tree

34
Q

What is CT scan used for

A

Gives the most information about abdominal pathology

order as ABD/pelvis

  • with or without contrast
  • IV or oral contrast
35
Q

Epidemiology, Pathophysiology, and classical symptoms of GERD

A

Gastroesophageal reflux disease
-10 to 20 percent of western world

Reflux of gastric contents through the lower esophageal sphincter (LES) into the esophagus or oropharynx to cause symptoms, injury to esophageal tissue

Classic symptoms:
-heartburn (pyrosis)
-regurgitation/refux
Alarming symptoms:
-new onset of dyspepsia
-gastrointestinal bleeding
-persistent vomiting
-dysphagia
-odynophagia
-unexplained weightloss
-iron deficiency
36
Q

What is the treatment of GERD?

A

Lifestyle modification:
-weight loss if obese, elevated head of bed, elimination of dietary triggers, avoid alcohol and smoking

Antacids:
-calcium carbonate, aluminum hydroxide

Surface agents:
-sucrafate

H2 Blockers:

  • decreases the secretion of acid by inhibiting the histamine 2 receptor on the gastric parietal cell
  • zantac

Proton pump inhibitors:

  • most potent inhibitors of gastric acid secretion by irreversibly inhibiting hydrogen potassium (H-K) ATPase pump
  • ex. omperazole
37
Q

Peptic Ulcer disease PUD

A

Peptic ulcers are defects in the gstric or duodenal mucosa that extend through the muscularis mucosa

Risk factors:

  • Helicobacter pylori infection
  • NSAID
  • smoking and alcohol consumption

Symptoms:

  • can be asymptomatic
  • upper abd pain, primarily epigastric but can be in RUQ and LUG

Most common cause of UGI bleeding (50% of all UGIB)

38
Q

Gastric ulcer

A

location is typically in the lesser curvature of the antrum of the stomach

Loss of protective mucosal barrier due to decrease acid secretion

Sharp burning epigastric pain
worsens right after eating

treatment:
-H2 blocker, proton pump inhibitor, eradicate H. Pylori

39
Q

Duodenal ulcer

A

More common than gastric ulcer

location is the anterior wall lining of proximal duodenum
-multiple ulcers or ulcers distal to 2nd portion of duodenum

increase gastric acid secretion

gnawing episgastric pain
-worsens 3-5 hours after eating
may be relieved by eating food

Treatment:
-H2 blocker, proton pump inhibitor, eradicate the H. pylori

40
Q

what are the disease associate with helicobacter pylori

A

Most prevalent chronic bacterial disease known

causes:
-peptic ulcer disease, chronic gastritis, gastric adenocarcinoma, gastric mucosa, associated lymphoid tissue (MALT) lymphoma, and duodenal ulcers

41
Q

Pathophysiology behind Helicobacter pylori and how do we test for it?

A

Bacterial urease hydrolyzes gastric luminal urea to form ammonia that helps neutralize gastric acid and form a protective cloud around the organsim that enables it to penetrate the gastric mucus layer

affects the:

  • Increased gastric acid secretion
  • gastric metaplasia
  • immune response
  • mucosal defense mechanisms
42
Q

How to test for H. pylori

A
Urea breath test
Fecal antigen test
detection of antibodies in serum
Upper endoscopy with gastric biopsy
-warthin starrys silver stain and immunohistochemistry stain

Remeber to have patient stop proton pump inhibitor medication for 14 days before fecal and breath tests otherwise have high chance for false negative tests

43
Q

what are the three different types of blood appearances for the GI tract and what do they tell us?

A

Hematemesis: vomiting of blood or coffee ground like material

Melena:
black tarry stools
-90% of the time is secondary to an UGIB

Hematochezia:

  • red or maroon blood in stool
  • usually due to lower GI bleed
  • can occur with massive upper GI bleeding
44
Q

where is the line between the UGIB and LGIB?

A

UGIB:

  • ANy GI bleed orginating proximal to the ligament of treitz
  • esophagus, stomach, duodenum

LGIB:

  • any GI bleed originating distal to the ligament of Treitz
  • Jejunum, ileum, colon, and rectum
45
Q

Causes of UGIB:

A
  • peptic ulcer disease
  • erosive gastritis and esophagitis
  • esophageal and gastric varices (from portal hypertension)
  • vasuclar anomalities
  • malignancy
  • mallory-weiss tear
  • aorto-enteric fistula
46
Q

causes of LGIB:

A
  • Diverticulosis
  • vascular anomalies
  • malignancy
  • IBD
  • crohns, ulcerative colitis
  • anorectal disease
  • anal fissures
  • hemmorhoids
  • colitis (ischemic or infectious)
47
Q

what are Esophageal and gastric varices

A

Dilated suubmucosal veins resulting from portal hypertension

often result of alcoholic liver disease

prone to re-bleeding

high mortality rate

Variceal bleeding is the cause of UGI bleeding in cihotics 59% of the time followed by peptic ulcer disease in 16% of cases

48
Q

what are the three presentations of gallstones

A
  • asymptomatic
  • classic presentation of biliary colic (pai in RUQ and worse after eating greasy foods)
  • Complications of gallstone disease
49
Q

Cholelithiasis:
Cholecystitis
Choledocholithiasis:

A

Cholelithiasis: gall stones

Cholecystitis: inflammation of the gallbladder second to stone or obstruction in neck of GB or cystic duct

  • gall bladder cant drain bile but liver can
  • LFT normal

CHoledocholithiasis:

  • stone stuck in the common bile duct
  • neither the GB nor the Liver can drain bile
  • LFT elevated
50
Q

Ascending cholangits:
Gallstone pancreatitis:
Dysfunctional GB:

A

Ascending cholengitis:

  • biliary tree gets inflamed and infected
  • many times from stone in the common duct
  • air in biliary tree

Gallstone pancreatitis:
-gallstone get stuck in pancreatic duct causing elevated LFTs and Pancreatic enzymes (lipase and amylase)

Dysfunctional GB:

  • no stones but GB does not empty well
  • symptoms of biliary colic
  • diagnosed with HIDA scan
51
Q

Pancreatitis:

A

Pathophysiology:
-acute panceatitis is an inflammatory condition of the pancreas characterized by abdominal pain and elevated levels of pancreatic enzymes in the blood

Risk factors: Gallstones, alcohol abuse, hypertriglyceridemia

Presentation:
-acute onsent of persistent severe epigastric pain (often radiating to back) nausea vomiting and epigastric tenderness on palpation

Diagnostic workup:

  • CBC, CMP, LIpase, UA, preg test,
  • imaging on case by case, CT scan or US

Treatment:

  • IV fluids, pain and nasuea medication
  • NO or clear liquids
52
Q

Appendicitis

A

Pathophysiology:
-inflammation of the appendiceal wall followed by localized ischemia, perforation and the development of a contained abscess or generalized peritonitis

Presentation:

  • RLQ abdominal pain, anorexia, nausea/vomiting. may have fever
  • positive mcBurneys point and sharp somatic pain

Workup:

  • CBC,CMC, UA, preg test
  • CT scan or US

treatment:

  • surgery
  • NPO, IV fluids, pain and nausea medication
53
Q

DIverticulitis/ Diverticulosis:

A

Pathophysiology: Diverticulitis
-erosion of the diverticular wall by increased intraluminal pressure or impacted food particles. inflammation and focal nercosis ensue, leading to perforation

Pathophysiology: Diverticulosis
-presence of diverticulum (sac like protrusions of the colonic wall)

Classic presentation:

  • abdominal pain in LLQ
  • nausea vomiting maybe a fever
  • LLQ tenderness

Workup:

  • CBC,CMC, UA, preg test
  • CT scan

Treatment:

  • antibiotcs
  • maybe surgery
54
Q

Achalasia

A

Pathophysiology:

  • progressive degeneration of ganglion cells in myenteric plexus in the esophageal wall leading to failure of relaxation of the lower esophageal sphincter
  • also loss of peristalsis in the distal esophagus
Symptoms:
-progressive dysphagia
-regurgitation
weight loss
-substernal discomfort

Diagnosis:

  • Barium esophagus to get birds beak appearance
  • esophageal manometry confirms

treatment:

  • BoTox
  • dilation
  • surgery
55
Q

Chagas Disease

A

Secondary achalasia

  • esophageal dysfunction
  • found in mexico, central and south america
  • caused by the parsite: trypanosoma cruzi
  • protozoan disease
56
Q

Zollinger Ellison Syndrome gastrinoma

A

Pathophysiology:

  • caused by secretion of gastrin by duodenal or pancreatic neuroendocrine tumor
  • gastric acid hypersecretion results in severe acid related peptic disease and diarrhea

Consider when:

  • intractable ulcer
  • ulcers in atypical locations
  • ulcer associated with diarrhea, steatorrhea, weight loss, nausea/vomitting

Significantly elevated fasting gastrin and positive secretin stimulation test

57
Q

Viscerosomatics: Paraympathetics

A

Upper portion: esophagus thru transverse colon
-OA, AA (vagus n)

Lower portion: Descending colon, sigmoid, rectum
-S2-S4 (pelvic splanchnic n)

58
Q

Viscerosomatic sympathetic levels:

A
T12 - appendix
T2-8- esophagus
T5-9- stomach
T6-9- liver
T6-9- gall bladder
5-T9, T9-T12- small intestine
T9-L2- Colon
T5-T11- Pancreas