Gi Flashcards
ph findings in mesenteric ishaemia
- metabolic acidosis
when does mesenteric adenitis typically happen
- after URTI
3 types of mechanical intestinal obstruction
- luminal; gallstones, faeces, foreign body, meconium
- intra mural; strictures, intussusception
- extraluminal; hernia, adhesions, volvulus
different symptoms depending on small vs large bowel obstruction
Small; pain = high frequency colic, central vomit = early distention = late constipated = late
large bowel
- pain = low frequency colic, lower abdo
- vomit = late
- distention = early
- constipated = early
causes of paralytic intestinal obstruction
- sympathetic activity; reflex post op, rtroperitoneal bleed, malignancy
- bacteria
- biochem = k, urea, ca
- opiates, anticholinergics
- inflammation
what is considered dialtation in the small bowel
- > 3cm.
- valvulae coneventei all the way round
what is considered dilatation in large bowel
- 6cm +
- haustra not all the wat
what condition do you get the late sign of hiccups
- Peptic ulcer perforation
what glasgow blatchford score do you need to have a high chance of needing an intervention for UGI bleed
- 6+
what score predicts a high risk of death from UGI bleed in the rockall system
- > 8
if a patient has haematemesis due to UGI bleed, where most likely is the problem
- proximal to the duodenal jejunal flexure
what one Warfarin reversal agent do you not give in UGI bleed
- PCC, give FFP and plt instead if needed
what are the ALARMS symptoms
- anaemia
- loss of weight
- anorexia
- recent onset of progressive symptoms
- Malaena/ haematemesis
- Swallowing issues
how long before OGD must a patient nto eat
- 6hrs
what kind of cancer does barrets usually become-
invasive adenocarcinoma
define short vs logn barretts
- <3cm
- >3cm
surveillance guidance for baretts
no dysplasia - 2-5yrs
low grade; 6/12; biopsy every 1cm. radiofrequency ablation
high grade - 3/12. if visible lesion = endoscopic ablation with mucosal resection or radiofrequency ablation / oesophagectomy
typical sx Oesophageal ca
- dysphagia progress from solids to liquids
symptoms of diffuse oesophageal spasm
- intermittent dysphagia +/- chest pain
what is the mechanism behindd achalasia
- degeneration of myenteric plexus stopping the LES from relaxing
sx achalasia
- dysphagia
- regurg
- weight loss
rx achalasia
- endoscopic baloon dilatation
- hellers cardiomyotomy
then PPI
0r
Botox if no surgery
CCB and nitrates also relax sphincter
plummer vinson sydrome triad
- oesephageal webs
- IDA
- post cricoid dysphagia
which type of oesophageal ca is HPV a RF for
- squamous
what are you doing in a iv lewis oesophagectomy
- right sided thoractomy
- stomach into chest and oesophagus division mobilised
- anastamosis = intrathoracic oesophagogastric
what is zollinger ellison syndrome
- pancreatic or gastric gastrin secreting tumour
zollinger ellison syndrom sx
- abdo pain, dyspepsia, chornic diarrhoea and steatoorhea due to inactivation of pancreatic enzymes and damaged intestinal mucosa
zollinger ellison syndrom ix
- fastign gastrin level in serum . 3 x 3 days
- hypochlorhydria = reduced acid production will also cause increased gastrin production - ph will be <2
zollinger ellison syndrome rx
- high dose PPI
- surgery unless MEN1 = multiple adn mets #- somatosatin analogue and chemo
what type of ab is produced in h pylori
igg
screening test for h pylori and instructions
- urea breath test; stop abx 4 weeks before and PPis 2 weeks before
what does NICE recommend for gastric ulcers
all to biopsy as high malignant potential
rf gastric ca
- h pylori
- smoking
- alcholo
- diet high in nitrates
- EBV; diffuse type
- autoimmune gastritis
- e cadherin mutation = diffuse type. fhx
- FAP - intestinal type
two types of gastric adenoca
- diffuse = worse prognosis, young people. signet cells
- intestinal - old - better prognosis
where does gastric ca spread to
- Lymph
- lungs, liver, brain, ovaries via transcoelemic
rx gastric ca
- <5cm to OG jnct - total gastrectomy
- 5-10cm from jnct = sub total gastrctomy
+/- ESSMR
+ d2 NODAL RESECTION + chemo
name the 3 types of surgery that can be done for gastric ca
- bilroth 1
- bilroth 2
- roux en y
what is bilroth one surgery
- partial gastrectomy with simple anastamosis
what is bilroth 2 surgery
- partial gastrectomy wtih duodenal stump oversewn and anastamosis in jejunum
roux en y
- total or partial
- proximal duodenum oversewn
- proximal jejunum divided from distal
- proximal jejunum connects to oesophagus
- distal duodenum connects to jejunum
what is mirizzi syndrome
- compression of common bile duct by stone impacted in cystic duct
what can present similarly to jaundice
- hypercarotenaemial after prolonged and excess consumption of foods containing carotene
how to treat ascending cholangitis
ERCP
which anaesthetic can cause jaundice
- halothane
what liver problem is xanthelesmata a indication of
- primary biliary cirrhosis
what happens to colour of urine in hepatic jaundice
- darker as conjugated bilirubin is excreted by the kidney
what happens t o colour of urine and stools in post hepatic jaundice
- dark urine
- pale stool
common drugst that cause cholestatic jaundice
- fluclox
- steroids; cocp, anabolic
- sulfonylureas
- prochloperazin r
- chlorpromazine
where is hep a an endemic
- south america and africa
incubation period of hep a
2-6 weeks
what type of vaccine is available for hep a and who gets it
- inactivated = havrix monodose
- at risk; travellers tp endemic areas, close contacts, chronic liver disease, blood clotting disorders, MSM, IVDU, Occupational, HIV
hep b incubation period
- 1-6 months
what bone issue do patients with hep a and b get
- arthralgia
what does antihbs indicate
- previous immunisation or exposure
what does hbsag indicate
- current infection
what does anti hbcag indicate
- past infection
- sometimes current
what does hbeag indicate
- infectivity
complications of hep b infection
- chronic; ground glass hepatocytes on microscopy
- HCC
- cryoglobulinaemia
- polyarteritis nodosa
- glomerulonephritis
- fulminant liver failure
when are kids immunised for hep b
2,3,4 minths
what do the following anti-Hbs levels mean
post immunisation
- > 100
- 10-100
- <10
- adequate response, no more test. booster at 5yrs
- suboptimal response. 1 more dose. if immunocompetent then no further tests needed
- non responser. test for current or past infection. give course of 3 vaccinations and testing after.
rx hep b
- pegylated interferon 1st
- tenofovir 2nd
hep c incubation period
- 6-9 weeks
can you breastfeed if you have hep b/c
yes
hep c ix
- HCV RNA
hep c complications if chronic
- arthralgia, arthritis
- sjogrens
- HCC, Cirrhosis
- cryoglobulinaemia
- porphyria cutanea tarda esp with alcohol abuse
- membranoproliferative glomerulonephritis
what is porphyria cutanea tarda
- blistering skin on sun exposure
rx hep c acute
- support
rx hep c chronic
- test viral genotype
- protease inhibitor +/- ribavarin
ribavarin SE
- Cough, haemolytic anaemia. teratogen. cotnraception till 6 months after stopping
hep d ix and rx
= anti hdv if hbsag present
- INF alpha
what should babies born from hep c/b positive mums have
- full course vaccien + ig
2 types of autoimmune hepatitis
- 1 = 80%, young and middle aged. anti - SMA +ve, 10% ANA +Ve. IgG raised
- Type 2 - anti-LKM1 +ve . ana and asma -ve
kids and europe
rx autoimmune hepatitis
- prednisolone
- azathiprime for maintenance from remission usually in 2-3 yrs
- transplant
what is the classification system for encephalopathy
- west haven
west haven classificaiton of encephalopathy grades
- sleep reversasl, lack of awareness, short attention span, impaired computations
- lethargy, memory impaired, personality change, asterixis
- somnolence, confused, disorientated. hyper-reflexia, nystagmuus, clonus, rigidity
- stupor/ coma
rx encephalopathy
lacutlose
rifaximin as prophylaxis
indicators of poor prognosis in acute liver failure that is paracetemol induced
- ph 7.3 or
- INR >6.5/ PT >100seconds
- grade 3/4 encephalopathy
- creat >300
- lactate >£
indicators of poor prognosis in acute liver failure that is NOT paracetemol induced (also kings college criteria for transplant)
- Ph <7.3 post volume resus
- PT >100 s
or 3 of beloow - PT >50 (INR >3.5) - Bili >300 - jaundice to enceph >7/7 - age <10/ >40 - etiology; NANB (non hep a , non hep b) or drug induced
if acute liver failure and hepatic encephalopathy + cerebral oedema - RX
- Mannitol
- hyperventilate
5 stages of cirrhosis
- no varices
- varces
decompensated
- bleed
- ascites
- ascites bleeding
what metabolic issues canc ause decompensated liver failure
- hypokalaemia as causes ammonia to build up and cross BBB
- metabolic alkalosis
- increased protein intake = more ammonia
- constipation - prolonged exposure of GI content
RF for Alcoholic liver disease
- alcohol
- hep c
- female
- obese
what happens to plt in liver disease
- goes down due to splenic sequestration
what happens to na in liver disease
- down in cirrhosis
what happens to ast:alt ratio in cirrhosis
- > 1
what scoring system predicts prognosis in chronic liver disease
- child pugh