GI Flashcards
Which medication for GERD is contraindicated in pregnancy?
Misoprostol (induces abortions)
Which drug class for GERD/PUD can increase risk for osteoporosis?
PPIs
Which antiemetic class can cause extrapyramidal side effects like tardive dyskinesia?
Phenothiazines
Which antiemetic can cause seizure activity and is contraindicated with history of seizures?
Cannabinoids
Prokinetics are first line to treat ________.
Gastroparesis
What two GI med classes can cause extrapyramidal side effects?
Phenothiazines and prokinetics (reglan)
What are 3 options to treat Traveler’s diarrhea?
Bismuth subsalicylate (Pepto-bismol)
Loperamide (Imodium)
Rifaxamin
Which IBD drug class is for exacerbation only?
Corticosteroids
Avoid Reglan use within 2 weeks of ______ which could cause hypertensive crisis
MAOI
Which antiemetic class blocks serotonin on vagal nerve terminals and in the chemoreceptors trigger zone?
5-HT3 Receptor Antagonists
Ex: Zofran
Which drug class do you not administer live vaccines to?
TNF alpha inhibitors
Which antiemetic class can cause QT prolongation?
Serotonin antagonists (5HT3 receptor antagonists) Ex: Zofran
What class is considered the gold standard for the treatment of mild to moderate Crohn’s and UC?
Aminosalicylates
Ex: sulfasalazine, Mesalamine
There is a black box warning against what medication when used with PPIs?
Plavix
H2 receptor antagonists reduce gastric acid secretion by ____% ?
35-50%
PPIs reduce gastric acid secretion by ____% ?
If taken after food what %?
Up to 90%
After food will only decrease 50%
What is the order of potency of these H2 blockers?
Famotidine, cimetidine, Ranitidine
famotidine (most potent)
ranitidine
cimetidine (least potent)
Ranitidine is 5-12x more potent than cimetidine.
Famotidine is 30-60x more potent than cimetidine.
Which antiemetics used for chemotherapy n&v?
Sedatives/hypnotics, cannabinoids, serotonin antagonists, and reglan
Which Med for GERD/PUD can cause osteoporosis?
PPIs
Which Med for GERD/PUD can cause infections like CDiff or bacterial gastroenteritis?
PPIs
What is the 1st line treatment for H. Pylori?
What if they have sulfa allergy?
Triple therapy:
- PPI
- Amoxicillin
- Clarithromycin
Sulfa allergy: replace amoxicillin with Flagyl
