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Pharm 1 > GI > Flashcards

GI Flashcards

1
Q

Which medication for GERD is contraindicated in pregnancy?

A

Misoprostol (induces abortions)

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2
Q

Which drug class for GERD/PUD can increase risk for osteoporosis?

A

PPIs

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3
Q

Which antiemetic class can cause extrapyramidal side effects like tardive dyskinesia?

A

Phenothiazines

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4
Q

Which antiemetic can cause seizure activity and is contraindicated with history of seizures?

A

Cannabinoids

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5
Q

Prokinetics are first line to treat ________.

A

Gastroparesis

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6
Q

What two GI med classes can cause extrapyramidal side effects?

A

Phenothiazines and prokinetics (reglan)

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7
Q

What are 3 options to treat Traveler’s diarrhea?

A

Bismuth subsalicylate (Pepto-bismol)
Loperamide (Imodium)
Rifaxamin

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8
Q

Which IBD drug class is for exacerbation only?

A

Corticosteroids

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9
Q

Avoid Reglan use within 2 weeks of ______ which could cause hypertensive crisis

A

MAOI

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10
Q

Which antiemetic class blocks serotonin on vagal nerve terminals and in the chemoreceptors trigger zone?

A

5-HT3 Receptor Antagonists

Ex: Zofran

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11
Q

Which drug class do you not administer live vaccines to?

A

TNF alpha inhibitors

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12
Q

Which antiemetic class can cause QT prolongation?

A 
Serotonin antagonists (5HT3 receptor antagonists) 
Ex: Zofran
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13
Q

What class is considered the gold standard for the treatment of mild to moderate Crohn’s and UC?

A

Aminosalicylates

Ex: sulfasalazine, Mesalamine

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14
Q

There is a black box warning against what medication when used with PPIs?

A

Plavix

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15
Q

H2 receptor antagonists reduce gastric acid secretion by ____% ?

A

35-50%

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16
Q

PPIs reduce gastric acid secretion by ____% ?

If taken after food what %?

A

Up to 90%

After food will only decrease 50%

17
Q

What is the order of potency of these H2 blockers?

Famotidine, cimetidine, Ranitidine

A

famotidine (most potent)
ranitidine
cimetidine (least potent)

Ranitidine is 5-12x more potent than cimetidine.
Famotidine is 30-60x more potent than cimetidine.

18
Q

Which antiemetics used for chemotherapy n&v?

A

Sedatives/hypnotics, cannabinoids, serotonin antagonists, and reglan

19
Q

Which Med for GERD/PUD can cause osteoporosis?

A

PPIs

20
Q

Which Med for GERD/PUD can cause infections like CDiff or bacterial gastroenteritis?

A

PPIs

21
Q

What is the 1st line treatment for H. Pylori?

What if they have sulfa allergy?

A

Triple therapy:

  1. PPI
  2. Amoxicillin
  3. Clarithromycin

Sulfa allergy: replace amoxicillin with Flagyl

Pharm 1 (4 decks)

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