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Pharm Clinical Correlates > GI > Flashcards

GI Flashcards

1
Q

5 GI alarm sxs…

A

dysphagia

Bleeds (hemeatemesis, melena)

anemia

CA sxs or hx

inadequate response to tx

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2
Q

1st line tx for GERD with no alarm sxs

A

H2 blockers

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3
Q

5 meds that can cause pill esophagitis?

A 
bisphosphonates
Fe
nsaids/ASA
potassium
tetracycline
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4
Q

Tx for esophagitis…

A

omeprazole (PPIs)

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5
Q

instructions for PPIs…

A

take QAM 30 min before 1st meal

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6
Q

d/c instructions for PPIs

A

taper (prevent rebound)

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7
Q

how long for onset of action of PPIs?

A

3-5 days

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8
Q

4 risks of PPIs…

A

malabsorption (Ca, Mg, B12, Fe)

osteoporosis/fx

c. diff/infx

kidney disease

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9
Q

duration of PPI dosing…

A

lowest dose, shortest duration

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10
Q

caution in Mg antacids…

A

renal insufficiency

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11
Q

SE for Mg antacids

A

diarrhea

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12
Q

SE for aluminum antacids…

A

constipation

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13
Q

caution for sodium bicarb…

A

edema/cirrhosis/CHF/Renal impairment

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14
Q

calcium carbonate risk…

A

hypercalcemia

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15
Q

1st line tx for H. Pylori

A

PPI + Bismuth + Metro + tetracycline

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16
Q

H. pylori can lead to what 3 complications if not eradicated?

A

PUD
IDA
malignancy

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17
Q

when should PPIs be d/c before h. pylori testing?

A

1-2 weeks

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18
Q

When should bismuth and abx be d/c before h. pylori testing?

A

4 weeks

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19
Q

The below is a sign of what in PUD?

peritoneal signs

A

perf, penetration

20
Q

The below is a sign of what in PUD?

succession splash

A

obstruction

21
Q

3 meds + NSAIDs that complicate PUD

A

anticoags
ASA
steroids

22
Q

with PUD but need for NSAIDs, what can be given as an adjunct?

A

PPI

23
Q

This drug is used to prevent NSAID induced ulcers

A

misoprostol

24
Q

Dx study for PUD

A

EGD

25
Q

Best long-term tx for gastroparesis?

A

improved glucose control

small, frequent low fat, low residue meals

26
Q

Dosing strategy for metoclopramide…

A

lowest dose, shortest duration

risk of EPS

27
Q

Metoclopramide can be used for…

A

gastroparesis

28
Q

C/Is for metoclopramide

A

obstruction
perf
bleed

29
Q

Risks of ondansetron (3)

A

arrhythmia
prolonged QT
serotonin syndrome

30
Q

Cautions for promethazine/prochlorperazine

A

sedating

drug-induced Parkinsonism

31
Q

What antispasmodic can be helpful for IBS?

A

dicycloamine

32
Q

Dicycloamine has ______ properties, and should be used with caution in elderly patients

A

anticholinergic

33
Q

This drug for IBS can be considered for a psychosocial tx and abd. pain tx

A

amitriptyline

34
Q

IBS-D tx…

A

eluxadoline

35
Q

The following meds can help/hurt constipation?

antipsychotics
antidepressants
opiods

A

hurt

36
Q

Adverse effects of bulk-forming laxatives and tx…

A

flatulence, bloating

Fiber + fluid

37
Q

which anti-constipation?

opiod-induced constipation w/ advanced illness or non-cancer pain

A

methylnatrexone

38
Q

adverse reactions to anti-diarrheals (2)

A

ileus

toxic megacolon

39
Q

peptobismol is contraindicated in…

A

ASA allergy

40
Q

Tx for diverticulitis…

A

flagyl + cipro

41
Q

f/u for diverticulitis

A

colonoscopy 6-8 weeks after resolution

42
Q

tx for new IBD-UC

A

mesalamine

43
Q

acute IBD flare tx..

A

CS

44
Q

flagyl SE…

A

disulfiram rxn

45
Q

perianal crohn dz tx…

A

cipro + flagyl

Pharm Clinical Correlates (9 decks)

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