GI Flashcards
Antacids
Counteracts acids in stomach
Affects absorption of other medications
Take 2 hours apart from other meds and with a glass of water
Maalox, mylanta, tums, pesto-bismal
H2 blockers
Supresses gastric secretion
Zantac / Pepcid
Prokinetic Agents
Increases LES tone and promotes gastric emptying
Take prior to meals
Reglan
PPI
Supresses gastric acid secretion better than H2 blockers
Prilosec Prevacid ( omeprazole, lansoprazole)
GERD
LES dysfunction
Acid reflux = irritation of mucosa
Infective esophageal clearance of reflux caused by decreased saliva and decreased esophageal peristalsis at night
Delayed gastric emptying
Risk factors : anything that decreases LES
- anticholinergics, morphine, CCB, nitrates, alcohol, caffeine, spicy food, chocolate
- large meals, lying down after meals , tight clothing, obesity
Findings
- heartburn, burning 30-60 after eating, exacerbations by lying down or bending over, regurgitation, sour stomach
Atypical - asthma, cp, cough, sore throat
PE: mid epigastric tenderness, no blood in stool
GERD management
- Lifestyle
- Antacids ( mild to moderate)
H2 blockers ( severe)
Alginate acid ( acts as barrier ) - Gaviscon - PPI
- tx - 4-8 weeks with higher dose
- maintainance - lover dose
- Reglan w/ H2 or PPI
Be aware CNS affects
Peptic ulcer Disease
Painful ulcerations in the stomach
Either gastric or small intestine ( duodenal)
From : NSAIDS, H, Pylori, acid hypersecretory states
Pain better after meals = duodenal
Pain worse after meals = gastric
N/v/weight loss
PE: mild, localized epigastric tenderness to deep palpation
PUD treatment
- stop NSAIDS, smaller meals
H.plyori - two antibitoics and a PPI for 7-14 days
- flagly 500 mg, amoxicillin 1 gm BID,
- Prilosec 20 mg BID or Prevacid 30 BID
After treament continue on PPI or H2B PRN
Non Hpylori - gastric Prilosec 40 mg 4-8 weeks Prevacid 30 mg 4-8 weeks - duodenal - Prilosec 20 mg 4-8 wks - Prevacid 15 mg 4 weeks
Diarrhea
Increased stool freq > 3 BM per day of liquidity stool
Actute < 2 weeks
Chronic > 4 weeks
Acute noninflammatory
- watery, non bloody stool, abd cramping, bloating , n/v, caused by a virus
- no dx unless > 7 days
Acute inflammatory
- blood , pus or fever
- LLQm urgency, tensesmus, toxic bacteria.
Chronic diarrhea
Osmotic - water retention in bowel Secretory - cholera Inflammation - chrons, colitis Meds Malabsorption
PE, DX, diarrhea
PE: fever, weight loss, dehydration, tachy, poor skin tumor, hyperactive bowel sounds, generalized tenderness, stool may have blood
DX: stool culture, c.diff, CBC, electrolytes , sigmiodocosopy or colonoscopy for colitis
Labs for malabsorption
Fatty stool - 24 stool
Diarrhea treatment
Diet, rehydration, antidiarrheal agents, antibiotics
C-diff
Flagyl for mild to moderate cases - 500 mg 14 days
Vancomycin 125 mg 10 day - severe
No role for probiotics in lit
Avoid anti-peristaltics agents
Constipation
< 3 BM a week Dry, hard, straining Elderly predisposed - meds, poor eating, dental, mobility Multifactorial - slow colonic transit time, decreased colonic motility due to aging, cognitive impairments
Constipation H and PE
Change in pattern, character or color, any new medications, diet, fluid intake
PE: distention, abdominal tenderness, palpable stool in colon, decreased bowel sounds , rectal exam