GI Flashcards
T cell lymphoma is related to which GI disease?
Celiac disease
What substance is the drug Octreotide most similar to? which diseases is it used for?
Somatostatin
-Acromegaly, carcinoid tumor, VIPoma
What GI disease is associated with Fistulas, Noncaseating granulomas, Skip lesions, Transmural inflammation?
Crohn’s disease
what GI disease is related to Crypt abscesses?
Ulcerative colitis
Which nerve is responsible for the taste in the anterior 2/3rds of tongue?
Facial nerve (CN VII)
What nerve is responsible for sensation in the anterior 2/3rds of tongue?
Mandibular N (CN V3) - from trigeminal N.
What nerve is responsible for taste and sensation in the posterior 1/3 of tongue?
Glossopharyngeal N (CN IX)
What is the most common benign tumor of the parotid gland?
pleomorphic adenoma
What Abs are associated with Celiac disease?
Anti-endomysial Abs
Anti-Transglutaminase Abs
Anti-deamidated gliadin peptide antibodies
What microbial colonization is associated with Colon cancer?
Streptococcus bovis
What is the activity of Vasoactive intestinal peptide?
- smooth muscle relaxation
- water secretion into pancreatic juice/bile
- inhibits gastric acid secretion and absorption from intestinal lumen
What is a Sudan III stain used for?
identify unabsorbed fat and confirm malabsorption
identify:
extensive lymphocyte infiltration and granulomatous destruction of interlobular bile ducts
Primary biliary cirrhosis
identify: Middle aged woman Fatigue and pruritus (worse at night) Hepatosplenomegaly, cholestasis (jaundice, pale stool, dark urine) Malabsorption of ADEK xanthelasma formation
Primary Biliary cirrhosis
What is the first line treatment for Ulcerative Colitis?
5-aminosalicylic acid (5-ASA)
What renal dysfunction is associated with Crohn’s?
Calcium oxalate stones
-gut cant absorb all fats, so fat binds to calcium in stomach, leaves oxalate free to deposit in kidney
What are gastric ulcers most commonly found in the stomach?
Lesser curvature
What are liver biopsy finding early in Wilson Disease?
Macrovesicular steatosis
How is the diagnosis of Acute diverticulitis made?
CT of abdomen
What is the most common GI disorder associated with Down Syndrome?
Duodenal Atresia - failure of recanalization
- double bubble sign
- bilious emesis
35 year old woman present with severe heartburn
has facial telangiectasias
ulcers on tips of fingers
small calcium deposits in the soft tissues of hands and elbows
What is causing her heartburn?
underlying disease?
Fibrous replacement of the muscularis in the LES
CREST Syndrome Calcinosis Raynauds Esophageal Dysmotility (atrophy, fibrous replacement) Sclerodactyly Telangiectasia
finger ulcers are from chronic inflammation, vascular injury - ischemia
55 year old male present with worsening indigestion. epigastric tenderness
firm rubbery, mobile mass over left clavicle
pt has lost 25lbs since last appointment
what is most likely diagnosis?
gastric adenocarcinoma
mobile mass = supraclavicular lymphadenopathy on left hand side - VIRCHOW’s NODE
Patient present with chronic gnawing abdominal pain. pain starts within a few hours after a meal. Epigastric tenderness. Urea breath positive.
Patient is prescribed a drug that improves Sx but darkens stool and tongue
identify drug
Bismuth subsalicylate
pt presents with constipation, says over past 8 months stools have become smaller and smaller
12 lb weight loss since last visit
Contrast imaging shows “apple core” lesion
identify disease and underlying mechanism
Adenocarcinoma of colon
loss of APC gene (tumor suppressor)
Neonate drools, chokes, and vomit with first feeding
cyanotic when baby is feeding
very round and full abdomen
identify dz and related intrauterine causes
Tracheoesophageal fistula
a/w polyhydramnios in utero
small bowel coming straight off cecum and twisted around a marginal artery or around left branch of ileocolic artery
identify dz and cause
Jejunal and ileal atresion
–disruption of mesenteric vessels = ischemic necrosis = segmental resorption
“APPLE PEEL ATRESIA”
infantile dysphagia - nonbilious projective vomiting
palpable olive mass in epigastric region
identify dz, associated cause, and resulting electrolyte disturbances
Pyloric stenosis
a/w Macrolide exposure
Hypokalemic, Hypochloremic metabolic alkalosis (secondary to vomiting)
what is the embryonic origin of the spleen, what is blood supply
Mesoderm foregut supply (celiac - splenic A)
What are the 3 structures contained in the hepatoduodenal ligament?
Proper hepatic artery
Portal Vein
Common bile duct
What are the layers of the gut wall? (from inside to outside)
which 2 layers are the 2 nervous supply located? what are their functions
MSMS
- Mucosa
- Submucoa - MeiSSner plexus - secretes fluid
- Muscularis externa - Auerbach - motility
- Serosa (intraperitoneal), Adventitia (retroperitoneal)
Skin hyper pigmentation
Diabetes Mellitus
hepatomegaly (MICROnodular cirrhosis)
what is the most effective treatment?
Hemochromatosis
abnormally high iron GI absorption
Tx: phlebotomy
What is the therapy for hepatic encephalopathy? what other drug (mechanism?) is this typically coupled with?
RIFAXIMIN (or neomycin) - nonabsorbable abx that alters GI flora to decrease production of ammonia
used in addition to LACTULOSE (increases conversion of ammonia to ammonium) - acidifies colon contents
Pt presents with bloating and multiple watery diarrhea w/o blood.
Had gastric bypass surgery 3 years ago
Jejunal aspirate shows bacterial count >10^5 (small intestinal bacterial overgrowth)
what is probably increased in the patients serum?
Small intestinal bacterial overgrowth (SIBO)
Increased: Vit K, Folate (produced by enteric bacteria)
Decreased: Cobalamin, Vit A,D,E, iron, zinc
What is the mechanism and use of Diphenoxylate, Loperamide?
opioid anti-diarrheal agent - Slows motility
used in IBS
A patient who has been losing weight for a movie role presents with severe nausea, recurrent bilious vomiting. Began as postprandial epigastric pain and early satiety. Angle between SMA and aorta is diminished. What is the problem?
Small bowel obstruction:
Transverse part of the duodenum is pinched between SMA and aorta due to low visceral fat
pt has pmh of recurrent respiratory infections and chronic diarrhea. current meds: pancreatic enzyme therapy and dietary supplements:
Presents with decreased lower extremity proprioception and hyporeflexia. Labs shows mild hemolytic anemia
What is deficient in the patient
PMH: probably has CF w exocrine pancreatic insufficiency (malabsorption of ADEK)
Vit E deficiency = neuromuscular dz, hemolytic anemia
–cell membranes are predisposed to oxidative injury. long axons (large surface area) are easily damaged
Where is a Zenker diverticulum located? What is the underlying cause?
False diverticulum of upper esophagus
caused by Cricopharyngeal motor dysfunction
A mutation in which genes will cause a patients small early colon adenoma to:
- grow and develop late adenoma features
- transform into a carcinoma
- KRAS
2. TP53