GI Flashcards
Neutralize stomach acid by reacting with protons in the lumen
Antacids (TOPNOTCH)
Impairs absorption of tetracyclines, flouroquinolones,itraconazole and iron
Antacids (TOPNOTCH)
Antacids
Magnesium-Aluminum Hydroxide, Calcium carbonate, Sodium bicarbonate (TOPNOTCH)
Competitive pharmacologic block of H2 receptors ; for peptic ulcer disease, Zollinger-Ellison syndrome, Gastroesophagal reflux, dyspepsia
H2 Receptor Blockers (TOPNOTCH)
H2 Receptor Blockers
Cimetidine, Ranitidine, Famotidine, Nizatidine (TOPNOTCH)
Highly effective in suppressing nocturnal acid secretion but only modest effect on meal- stimulated secretion
H2 Receptor Blockers (TOPNOTCH)
Irreversible blockade of H/K ATPase in active gastric panetal cells. Long lasting reduction of meal stimulated and nocturnal acid secretion
Proton Pump Inhibitors (TOPNOTCH)
Proton Pump Inhibitors
Omeprazole, Lansopraole, Rabeprazole, Pantoprazole, Esomeprazole (TOPNOTCH)
usually enetric coated, needs 3-4 days treatment to achieve full effectiveness
Omeprazole, Lansopraole, Rabeprazole, Pantoprazole, Esomeprazole (TOPNOTCH)
SE: Diarrhea, headache, abdominal pain, Malaabsorption (Vit B12, Ca, Fe, Zn), Infections (respiratory, enteric), Hypergastrinemia, Atrophic gastritis
Omeprazole, Lansopraole, Rabeprazole, Pantoprazole, Esomeprazole (TOPNOTCH)
Binds to injured tissue and forms a protective covering with ulcer beds. Accelerates healing of peptic ulcers and reduces recurrence rate
Sucralfate (TOPNOTCH)
Forms a protective coating on ulcerated tissue. Stimulates mucosal protective mechanisms, direct antimicrobial effects and sequestration of enterotoxins
Bismuth Salicylate (TOPNOTCH)
SE: Abdominal pain, Diarrhea, Uterine cramping, Miscarriage
Misoprostol (TOPNOTCH)
Activates EP receptors. Causes incresed HCO3 and mucus secretion in stomach. Uterine contraction
Misoprostol (TOPNOTCH)
SE: Black stools, darkening of tongue, Encephalopathy (Atraxia, headaches, confusion, seizures)
Bismuth Salicylate (TOPNOTCH)