GFR

Question 1

What are the 3 main processes of the nephron?

Answer 1

Filtration
Reabsorption
Secretion

Question 2

What is the equation for urinary excretion rate?

Answer 2

Filtration rate + secretion rate - reabsorption rate

Question 3

How many L of filtrate per day and urine per day is produced?

Answer 3

Filtrate - 180L/day

Urine - 1.5L/day

Question 4

What is GFR?

Answer 4

Volume of filtrate produced by all nephrons in both kidneys per unit time

Question 5

What part of plasma is excluded from filtrate?

Answer 5

Blood cells & plasma proteins

Question 6

What is the equation for GFR?

Answer 6

GFR = Kf x NFP

Question 7

What is net filtration pressure dependent on?

Answer 7

Sum of hydrostatic pressures & collloid osmotic pressures of glomerulus & bowman’s capsule

Question 8

How does AA dilation/EA constriction effect GFR?

Answer 8

Increases

Question 9

How does AA constriction/EA dilation effect GFR?

Answer 9

Decreases

Question 10

What are the two mechanisms of autoregulation of GFR?

Answer 10

• Myogenic response
• Tubuloglomerular feedback via JGA - links changes inn [NaCl] in tubule lumen to control of afferent arteriole resistances