Gestational trophoblastic disease Flashcards
what is GTD
group of pregnancy related tumour formed from abnormal placenta trophoblast cells
what are 3 RFx fof gtd
Asia & Africa extreme reproductive age prior GTD family history previous miscarriage use of OCP
what is a molar pregnancy
aka hydatidoform mole
fluid filled mass if cells
abnormal growth of trophoblastic cells into the placenta
how many types of molar pregnancies are there
2
what is a partial molar pregnancy
a) 2 sperm fertilise 1 eggs = too much genetic information
b) 1 sperm fertilises 1 egg but it contains no genetic material and therefore cannot develop
a) 2 sperm fertilise 1 eggs = too much genetic information
triploid
partially develop but not viable
what is a complete molar pregnancy
b) 1 sperm fertilises 1 egg but it contains no genetic material and therefore cannot develop
no foetal tissue and no DNA
empty ovum
when does commonly GTD develop
1st trimester
what are the 2 main symptoms experienced in GTD
vaginal bleeding
abnormal pain
early stages of pregnancy
vaginal passage fo grape like masses
in which types of pregnancy are symptoms of GTD more present and why
complete molar pregnancy
due to higher levels of b- hCG
on examination how does the abdomen appear
soft and boggy
why might a GTD patient experience thyrotoxic features
B-hCG mimic TSH
what thyrotoxic features might a GTD patient experience
tachycardia
tremor
sweating
hypertension
what bedside investigations might you preform in a GTD patient
urine b-hCG abnornally high
> 100,000
what blood test might you perform in a GTD patient
blood B-hCG to monitor GTD
TSH
what imaging would you perform in a GTD patient
ultrasound
