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Gynae & Obs disorders > Endometrial cancer > Flashcards

Endometrial cancer Flashcards

1
Q

where does endometrial cancer originate

A

endometrium (lining of the uterus)

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2
Q

what types of cancer orginates from the lining of the uterus

A

endometrial cancer

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3
Q

which is the most common type of gynaecological cancer

A

endometrial cancer

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4
Q

list 3 RFx for endometrial cancer

A

age >50 yrs
family hisotry
genetic: HNPCC

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5
Q

what is HNPCC

A

hereditary nonpolyposis colorectal cancer

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6
Q

which types of cancer are at increased of developing with HPCC

A

endometrial cancer

colorectal cancer

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7
Q

which type of endometrial cancer is the most common

type 1
type 2

A

type 1

80-90% prevalence

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8
Q

what is the MOA of type 1 endometrial cancer

A

oestrogen dependent = endometrial hyperplasia and malignancy

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9
Q

which type of endometrial cancer has a worser prognosis

A

type 2

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10
Q

what symptoms do 90% of patients with endometrial cancer present with

A

post menopausal bleeding

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11
Q

explain the endometrial referral pathway

A

any female >55 yrs + postmenopausal bleeding

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12
Q

what is the 1st line investigation for assessing endometrial cancer

A

transvaginal ultrasound

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13
Q

what would you see on a TVUS in a patient with endometrial cancer

A

endometrial thickening

features of malignancy

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14
Q

which is suggestive of endometrial cancer

  1. > 5mm thickening
  2. > 4mm thickening
  3. > 10mm thickening
  4. > 6mm thickening
A
  1. > 4mm thickening
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15
Q

what histological investigation can be performed to investigate for endometrial cancer

A

endometrial pipelle biopsy

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16
Q

what management is used for endometrial cancer

A

laparoscopic surgery

total hysterectomy
bilateral salpingo-oophrectomy

17
Q

what does a total hysterectomy involve

  1. remove both ovaries and tubules
  2. removal of the uterus and cervix
  3. removal of one/both fallopian tubes
A
  1. removal of the uterus and cervix
18
Q

what does a bilateral salpingo-oophrectomy

  1. remove both ovaries and tubules
  2. removal of the uterus and cervix
  3. removal of one/both fallopian tubes
A
  1. remove both ovaries and tubules
19
Q

what is the prognosis for localised endometrial cancer

A

5 yr survival

20
Q

list 3 management options for endometrial cancer

A

surgery
radiotherapy/chemotherapy
hormone therapy

21
Q

what is the salpingectomy

  1. remove both ovaries and tubules
  2. removal of the uterus and cervix
  3. removal of one/both fallopian tubes
A
  1. removal of one/both fallopian tubes
22
Q

what mutation can be associated with type 2 endometrial cancer

A

P53 mutation

23
Q

what are the two most common symptoms of endometrial cancer

A

unexplained abdo pain

bloating

24
Q

list 2 RFx for endometrial cancer

A

PCOS
nulliparous
menopause >52 yrs
obesity

Gynae & Obs disorders (11 decks)

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