German Immune System I Flashcards
When does Innate immediate immunity kick in?
0-4 hours
When does early induced innate response kick in?
4-96 hours
What molecules protect the skin chemically?
B-defensins, lamellar bodies, cathelicidin
What molecules protect the gut chemically?
a-defensins (cryptdins,) RegIII (lecticidins), Cathelicidin
What molecules protect the lungs chemically?
a-defensins (cryptdins), Cathelicidin
What molecules protect the nose/eyes/oral cavity?
Histamines, B-defensins
What are the most common types of chemical barriers?
Peptides and proteins (fewer but some lipids and carbs)
Where are most of the a-defensins made? made?
neutrophils
Where are most B-defensins made?
Epithelial cells (HBDs)
What brings defensins into the lipid membrane?
Electrostatic attraction and transmembrane electric field
What kind of defensins do you find in the mouth?
B defensins in the gingival, a-defensins in the junctional epithelium
What things are defensins used for?
Chemotaxis of WBCs, ACTH antagonist, opsonization, interaction with complement, cytotoxicity and growth promotion, wound repair, cell migration, histamine release from mast cells
Name 4 anaerobic bacteria that are mutualistic in the gut
Bifidobacterium
Clostridium
Bactericides
Eubacterium
Name 4 aerobic bacteria that are mutualistic in the gut
Escheria
Enterococcus
Streptococcus
Klebsiella
How does lysozyme work?
cleaves glycosidic bonds of peptidoglycan in cell walls of bacteria leading to lysis (found in tears, saliva, respiratory tract)
