Geriatrics Flashcards

1
Q

What are the elements on the FRAIL scale for the identification of frailty?

A

Fatigue
Resistance (climb 1 flight of stairs)
Ambulation (able to walk 80m)
Illness >5
Loss of weight (5% in past year)

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2
Q

What do the numbers on the CFS mean? (4-9)

A

4: Pre-frail
5: some iADLs affected
6: some bADLs affected
7: fully dependent
8: end-of-life, fully dependent
9: Terminally ill but not too frail

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3
Q

What are the 3 interventions to make to help a frail patient?

A
  1. Exercise, OT/PT
  2. Nutrition, milk feeds if necessary (check barriers to nutrition)
  3. Medication review
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4
Q

What should be the main focus when treating a frail patient?

A

What matters most to the patient

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5
Q

What are the factors that determine that a fall is severe?

A

Injury
>= 2 falls in the past year
Frailty
Unable to get up / lying on the floor
Unconsciousness / possible syncope

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6
Q

What are the medication classes in the STOPPFall criteria?

A

Postural hypotension inducing: alpha-blockers, central antihypertensives, vasodilators, diuretics
Psychotropics: antidepressants, antipsychotics, benzodiazepines, z-drugs
Opioids
Anticholinergics
Anconvulsants

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7
Q

What should be assessed after a fall is determined to be not severe?

A

gait and balance

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8
Q

Why is orthostatic hypotension still an issue even if the patient does not experience symptoms?

A

Lack of perfusion to legs may result in leg weakness

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9
Q

What are the 4 categories of drugs that increase fall risk (as identified by prof)?

A
  1. Anti-cholinergics
  2. Sedatives
  3. Orthostatic hypotension
  4. hypoglycemic agents
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10
Q

How to identify delirium with 4AT?

A

Alertness
Abbreviated Test: DoB, age, year, place
Attention: dec-nov-… or 30-3-3…
Acuity

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11
Q

What are some drug classes that may cause delirium?

A

Benzos, Z-drugs, opioids, anti-cholinergics, H2RA

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12
Q

What are some prominent drug classes that may prolong delirium?

A

Anti-infectives (FQ, cefepime)
Steroids
H2RA
Opioids
Dopamine agonists
Anti-convulsants (levetiracetam)
Hypoglycemics

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13
Q

Which delirium pharmacotherapy should not be used in Parkinsonism? Outline dosing regimen

A

IV/IM/SC Haloperidol 0.3-1mg BD (max 5mg/day)

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14
Q

Which delirium pharmacotherapy is parkinson-friendly? outline dosing regimen

A

PO Quetiapine 6.25-12.5mg BD (max 100mg)

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15
Q

Which delirium pharmacotherapy is QTc friendly? outline dosing regimen

A

PO Olanzapine 1.25mg - 2.5mg (max 10mg/day)

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16
Q

What are the risk factors of delirium? (4)

A
  1. > =65 yo
  2. current hip fracture
  3. cognitive impairment / dementia
  4. severe illness (inc frailty)
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17
Q

What are the 5 classes of drugs that can help with dizziness?

A
  1. anti-cholinergics
  2. anti-dopamine
  3. calcium channel antagonist
  4. benzodiazepines
  5. betahistine
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18
Q

How long should the patient experience dizziness for for drugs to be useful?

A

30 mins

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19
Q

What are the types of dizziness?

A
  1. vertigo
  2. pre-syncopal (OH)
  3. disequilibrium
  4. unspecified
20
Q

What anticholinergics can help with dizziness?

A

Prochlorperazine, dimenhydrinate, promethazine, scopolamine

21
Q

What anti-dopaminergic agents can help with N/V associated with dizziness?

A

metoclopramide

alt: ondansetron (serotonin)

22
Q

How does betahistine work and what are its contraindications?

A

H3 antagonist, partial H1 agonist, negligible H2 agonist
C/I in asthma, Hx of PUD

23
Q

What benzodiazepines can help with dizziness?

A

clonazepam, lorazepam, diazepam

24
Q

What calcium channel antagonists can help with dizziness?

A

cinnarizine

weight gain, sedation, antihistamine

25
Which classes of anti-dizziness medications cannot be used / used with caution in parkinsonism?
anti-dopamine, calcium channel antagonist
26
What is DIAPPERS for urinary incontinence?
Delirium Infection Atrophic vaginitis Psychosis Pharmacological Excessive urine Reduced mobility Stool impactions
27
What receptors are activated in the filling phase of the bladder?
B3 adrenergic alpha 1 adrenergic
28
What receptors are activated in the voiding phase of the bladder?
M3
29
How to manage stress incontinence?
Kegels Topical estrogen Duloxetine
30
How to manage urge incontinence?
Kegels Topical estrogen b3 agonist: mirabegron M3 antagonist: solifenecin
31
How to manage overflow incontinence?
Outlet obstruction - treat BPH / underlying structural issues - bowel habit optimization bladder underactivity bethanechol, intermittent catheterisation
32
What are the general non-pharmacological strategies for the management of incontinence?
kegels timed voiding bladder retraining continence products weight loss, reduce irritants, water hygiene
33
How does phenytoin affect the bioavailability of dexamethasone?
induces CYP3A4, decrease bioavailability
34
How does clarithromycin interact with digoxin?
inhibit p-gp, increase conc. of digoxin, increase toxicity
35
What drugs are affected by a decrease in gastric acid?
1. vit B, Ca, Fe 2. Azoles - keto decrease - itra (capsule) increase or decrease - vori, pos may be affected too 3. Cancer -tinibs: dasatinib, erlotinib
36
What drugs result in reduced gastric emptying?
opioids, anticholinergics
37
When must albumin be taken into account when interpreting phenytoin dose?
albumin < 40
38
What happens to the blood brain barrier in the elderly?
becomes more leaky, p-gp become more forgiving
39
How does frailty affect metabolism?
decreases metabolism cuz inflammation
40
What are the common inhibitors of liver enzymes?
Azoles, clarithromycin, cimetidine
41
What are the common inducers of liver enzymes?
phenytoin, CBZ, rifampins
42
Why does phase I metabolism decrease in older age?
decreased liver mass, reduced liver blood flow, thickening of sinusoidal epithelium
43
When should dialysis patients not be given NSAIDs?
when there is residual kidney function
44
When is a patient at risk of AKI?
dehydrated + diuretics, NSAIDs, coxibs, ACEi
45
Which drugs should not be used in patients with DLB / PDD / parkinsonism due to increasing risk of neuroleptic sensitivity reaction?
Metoclopramide, prochlorperazine, promethazine, antipsychotics (except low dose quetiapine)
46
Why are patients with dementia more sensitive to anticholinergic agents?
decrease ACh reserves
47