Drug Information Flashcards
What are the 7 DI categories?
- Availability & Identification
- Parenteral administration & compatibility
- Drug use in pregnancy and lactation
- Drug interactions
- Adverse drug reactions
- Dosage & Administration
- Choice of therapy / disease management
What are the references to approach for product availability?
HSA website
Institution formulary
Which references can be used to identify local products?
MIMS online
Mediview
Which references can be used to identify overseas products?
MIMS online
Martindale
Which references can be used to identify US products?
Lexi-drug ID
Micromedex Drug ID
What are the top 3 suitable references for adult parenteral administration queries?
Product insert
AHFS Handbook on injectable drugs (Trissel’s)
Uptodate Lexicomp
What are the suitable references for paediatric parenteral administration queries?
Product insert
Teddy Bear Book
What are the top 3 suitable references for stability and compatibility of parenteral substances?
AHFS Handbook on injectable drugs
Trissel’s 2.0
King’s Guide
What are the top 3 suitable references for drug use in pregnancy?
Briggs (Drugs in pregnancy and lactation)
Uptodate Lexicomp
Micromedex
What are the specialised references for pregnancy?
Briggs (Drugs in pregnancy and lactation)
CDC Treating for Two
OTIS Mother to Baby
What are the top suitable references for drug use in lactation?
Briggs
Hales
Micromedex
Uptodate Lexicomp
What are the specialised references for lactation?
Hales
LactMed
What are the top 3 suitable references for adverse drug reactions?
Uptodate Lexicomp
Micromedex
Meyler’s side effects of drugs
What are the top 3 suitable references for general drug interactions?
Lexi-comp Drug Interactions
Micromedex Drug Interactions
Stockley’s Drug Interactions
What are the top 2 suitable references for drug-herb interactions?
Natural Medicines
NIH Office of Dietary Supplements
What are the top 4 suitable references for dosing and administration?
Uptodate Lexicomp
Micromedex
BNF
PIL
What are the specialty references for renal dosing?
The renal dosing drug handbook
Drug prescribing in renal failure
Renal pharmacotherapy
What are the specialty references for children?
Lexi-comp Peds and Neonates
BNF for Children
What are the specialty reference(s) for hepatic dosing?
Drugs and the Liver
What are the specialty references for antimicrobials?
Sanford guide to antimicrobial therapy
What are the specialty references for enteral feeding tubes?
Handbook of drug administration vias enteral feeding tube
What are the top 3 suitable references for disease management?
Pharmacotherapy textbooks
Uptodate topic guides
Clinical practice guidelines / review papers
What should be done if the answer cannot be found in the references?
Primary literature should be looked at
What information should be responded with for an availability & identification query?
Generic and brand name
Origin and uses of drug
Available form and strength
Special restrictions? (P-only, POM…)
If not available, recommend alternative / other pharmacy
In what conditions should we be cautious about the types and amounts of fluid in parenteral administration?
Heart failure / renal: Fluid restriction
Diabetes: cannot sugar too high (dextrose a problem)
Renal / elevated sodium: cannot sodium too high
What information should be responded with for a parenteral administration query?
Reconstitution instructions (diluent, withdraw, further dilution, route - IV/IM/SC)
What information should be responded with for a parenteral stability / compatibility query?
Concentration
Details of study
Communicate compatibility (conc., diluent) or incompatible (why?)
What is the safe % for relative infant dose (RID)?
10%
What types of drugs are typically safe in preg and lact?
Drugs that are not bioavailable
What information should be responded with for a pregnancy / lactation query?
Recommendation
Classification ratings
Monitoring required?
Strategies to minimize exposure
Non-pharm to minimize drug use
What information should be responded with for an adverse drug reaction query?
Description of ADR
Mechanism (Class effect?)
Frequency
Usual onset
Dose-related?
Reversibility
Management
Possible alternatives
What information should be responded with for a drug interaction query?
Outcomes of DDI (signs and symptoms, labs)
Mechanism
Onset, severity, duration
Significance
Management
Alternatives
What information should be responded with for a dosing / choice of therapy query?
Route
Dose and frequency
Initial, titration, max
Monitoring
Safety tips
