Genomics

Question 1

Definition of structural genomics

Answer 1

Structural genomics attempts to study the three-
dimensional (3D) structure of proteins encoded by a
genome. Therefore, the structural genomics approach
requires the knowledge of the genome sequence, which is integrated with experimental and modeling data to predict the 3D structure of proteins.

Question 2

Definition of functional genomics

Answer 2

functional genomics aims to study gene (and
protein) functions and interactions. Thus, functional
genomics focuses on processes, such as transcription,
translation, and proteinprotein interaction.

Question 3

list of genomics variations

Answer 3

SNPs & CNVs

Question 4

genomic rearrangment

Answer 4

insertion, deletion, inversion, transposion.1

Question 5

Pyrosequencing

Answer 5

Pyrosequencing is based on the sequencing by syn-
thesis principle. When DNA polymerase elongates the
DNA chain, pyrophosphates are released. Each released pyrophosphate triggers a series of reactions that generates a detectable quantum of light. pyrose-
quencing enables real-time detection of the sequence of a gene. Consequently, this technique is useful in the
rapid detection of point mutations in the sequence and
in SNP genotyping, including genotyping of microbes