Genital. Vulva 12/21

Question 1

Vulva lined by …..

Answer 1

squamous epithelium

Question 2

Vulva. what includes?

Answer 2

the skin and mucosa of the female genitalia external to the hymen (labia majora, labia minora, mons pubis, and vestibule)

Question 3

Bartholin cyst?

Answer 3

cystic dilation of the Bartholin gland

Question 4

Where is present Bartholin glands?

Answer 4

one gland is present on each side of the vaginal canal

Question 5

what praduce Bartholin glands?

Answer 5

mucus-like fluid that drains via ductus into the lower vestibule

Question 6

Bartholin cyst arises why? what population?

Answer 6

due to inflammation and obstruction of gland. Women of reproductive age

Question 7

Bartholin cyst presentation?

Answer 7

unilateral, painful cystic lesion at the lower vestibule adjacent to the vaginal canal.

Question 8

Unilateral, painful cystic lesion at the lower vestibule adjacent to the vaginal canal?

Answer 8

Bartholin cyst

Question 9

Condyloma. definition?

Answer 9

Warty neoplasm of vulvar skin, often large

Question 10

Warty neoplasm of vulvar skin, often large?

Answer 10

Condyloma.

Question 11

Condyloma. cause?

Answer 11

HPV 6 or 11 (more common), secondary syphilis (less common).. both Sex transmited

Question 12

Condyloma. HPV 6 or 11 - how called?

Answer 12

condyloma acuminatum

Question 13

Condyloma. Secondary syphilis - how is called?

Answer 13

Condyloma latum

Question 14

Condyloma. HPV histology?

Answer 14

kolicytes (HALLMARK OF HPV INFECTED CELLS)

Question 15

Condyloma. Risk to progress to carcinoma of HPV?

Answer 15

Rarely progress, because 6 and 11 are low risk HPV.

Question 16

Lichen sclerosis. characterized?

Answer 16

thinning of the epidermis and fibrosis (sclerosis) of the dermis

Question 17

thinning of the epidermis and fibrosis (sclerosis) of the dermis?

Answer 17

Lichen sclerosis.

Question 18

Lichen sclerosis. presentation?

Answer 18

white patch (leukoplakia) with parchment-like vulvar skin

Question 19

Lichen sclerosis. in what population?

Answer 19

postmenopausal women

Question 20

Lichen sclerosis. etiology?

Answer 20

possible autoimmune

Question 21

Lichen sclerosis. malignant or benign?

Answer 21

benign, but assoc. with slightly increased risk for squamous cell carcinoma.

Question 22

benign, but assoc. with slightly increased risk for squamous cell carcinoma?

Answer 22

Lichen sclerosis.

Question 23

Lichen simplex chronicus. characterized?

Answer 23

HYPERPLASIA of vulvar squamous epithelium

Question 24

HYPERPLASIA of vulvar squamous epithelium?

Answer 24

Lichen simplex chronicus.

Question 25

Lichen simplex chronicus. Presentation?

Answer 25

leukoplakia with thick, leathery vulvar skin

Question 26

Lichen simplex chronicus. symptoms?

Answer 26

chronic irritation and scratching

Question 27

Lichen simplex chronicus. benign or malignant?

Answer 27

benign. no risk of squamous cell carcinoma.

Question 28

Valvular carcinoma. definition?

Answer 28

carcinoma arising from squamous epithelium lining vulva

Question 29

Valvular carcinoma. prevalence?

Answer 29

rare

Question 30

Valvular carcinoma. presentation?

Answer 30

leukoplakia. need biopsy to differentiate from other causes of leukoplakia

Question 31

Valvular carcinoma. etiology?

Answer 31

may be HPV or non-HPV related

Question 32

Valvular carcinoma. If HPV related, what types?

Answer 32

Due to high-risk HPV typer 16 and 18

Question 33

Valvular carcinoma. risk factors to HPV related? what population?

Answer 33

HPV exposure due to multiple partners and early first age of intercourse. Occurs in women of reproductive age

Question 34

Valvular carcinoma. HPV related - arises from what?

Answer 34

Valvular intraepithelial neoplasia (VIN), a dysplastic precursor lesion characterized y koilocytic change, disordered cellular maturation, nuclear atypia, increased mitotic activity

Question 35

Valvular carcinoma. Non HPV related arises why?

Answer 35

due to long standing lichen sclerosis

Question 36

due to long standing lichen sclerosis?

Answer 36

Valvular carcinoma. Non HPV related

Question 37

Valvular intraepithelial neoplasia (VIN), a dysplastic precursor lesion characterized y koilocytic change, disordered cellular maturation, nuclear atypia, increased mitotic activity?

Answer 37

Valvular carcinoma. HPV related

Question 38

Valvular carcinoma. Non HPV related. population and what mechanism?

Answer 38

chronic inflammation and irritation eventually lead to carcinoma. In elderly women (>70y/o)

Question 39

Extramammary paget disease. characterized?

Answer 39

Malignant epithelial cells in the epidermis of the vulva

Question 40

Extramammary paget disease. Presentation?

Answer 40

Erythematous, pruritic, ulcerated vulvar skin

Question 41

Erythematous, pruritic, ulcerated vulvar skin?

Answer 41

Extramammary paget disease.

Question 42

Extramammary paget disease. represents what?

Answer 42

Carcinoma in situ, usually with no underlying carcinoma.

Question 43

Extramammary paget disease. Paget disease of nipple is characterized by what?

Answer 43

malignant epithelial cells in the epidermis of the nipple, but is almos always associated with and underlying carcinoma.

Question 44

Extramammary paget disease. related to underlying carcinoma?

Answer 44

No

Question 45

What is related to underlying carcinoma?

Answer 45

Paget disease of nipple

Question 46

Extramammary paget disease. Distinguish from what?

Answer 46

melanoma, which rarely occur in vulva

Question 47

Paget cells what is staining? 3

Answer 47

PAS+, keratin+, S-100-

Question 48

Melanoma what is staining? 3

Answer 48

PAS-, keratin-, S-100+

Question 49

PAS+, keratin+, S-100-?

Answer 49

Paget cells

Question 50

PAS-, keratin-, S-100+?

Answer 50

Melanoma