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1 STEP women patho > Genital. Vulva 12/21 > Flashcards

Genital. Vulva 12/21 Flashcards

1
Q

Vulva lined by …..

A

squamous epithelium

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2
Q

Vulva. what includes?

A

the skin and mucosa of the female genitalia external to the hymen (labia majora, labia minora, mons pubis, and vestibule)

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3
Q

Bartholin cyst?

A

cystic dilation of the Bartholin gland

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4
Q

Where is present Bartholin glands?

A

one gland is present on each side of the vaginal canal

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5
Q

what praduce Bartholin glands?

A

mucus-like fluid that drains via ductus into the lower vestibule

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6
Q

Bartholin cyst arises why? what population?

A

due to inflammation and obstruction of gland. Women of reproductive age

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7
Q

Bartholin cyst presentation?

A

unilateral, painful cystic lesion at the lower vestibule adjacent to the vaginal canal.

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8
Q

Unilateral, painful cystic lesion at the lower vestibule adjacent to the vaginal canal?

A

Bartholin cyst

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9
Q

Condyloma. definition?

A

Warty neoplasm of vulvar skin, often large

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10
Q

Warty neoplasm of vulvar skin, often large?

A

Condyloma.

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11
Q

Condyloma. cause?

A

HPV 6 or 11 (more common), secondary syphilis (less common).. both Sex transmited

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12
Q

Condyloma. HPV 6 or 11 - how called?

A

condyloma acuminatum

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13
Q

Condyloma. Secondary syphilis - how is called?

A

Condyloma latum

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14
Q

Condyloma. HPV histology?

A

kolicytes (HALLMARK OF HPV INFECTED CELLS)

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15
Q

Condyloma. Risk to progress to carcinoma of HPV?

A

Rarely progress, because 6 and 11 are low risk HPV.

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16
Q

Lichen sclerosis. characterized?

A

thinning of the epidermis and fibrosis (sclerosis) of the dermis

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17
Q

thinning of the epidermis and fibrosis (sclerosis) of the dermis?

A

Lichen sclerosis.

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18
Q

Lichen sclerosis. presentation?

A

white patch (leukoplakia) with parchment-like vulvar skin

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19
Q

Lichen sclerosis. in what population?

A

postmenopausal women

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20
Q

Lichen sclerosis. etiology?

A

possible autoimmune

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21
Q

Lichen sclerosis. malignant or benign?

A

benign, but assoc. with slightly increased risk for squamous cell carcinoma.

22
Q

benign, but assoc. with slightly increased risk for squamous cell carcinoma?

A

Lichen sclerosis.

23
Q

Lichen simplex chronicus. characterized?

A

HYPERPLASIA of vulvar squamous epithelium

24
Q

HYPERPLASIA of vulvar squamous epithelium?

A

Lichen simplex chronicus.

25
Q

Lichen simplex chronicus. Presentation?

A

leukoplakia with thick, leathery vulvar skin

26
Q

Lichen simplex chronicus. symptoms?

A

chronic irritation and scratching

27
Q

Lichen simplex chronicus. benign or malignant?

A

benign. no risk of squamous cell carcinoma.

28
Q

Valvular carcinoma. definition?

A

carcinoma arising from squamous epithelium lining vulva

29
Q

Valvular carcinoma. prevalence?

A

rare

30
Q

Valvular carcinoma. presentation?

A

leukoplakia. need biopsy to differentiate from other causes of leukoplakia

31
Q

Valvular carcinoma. etiology?

A

may be HPV or non-HPV related

32
Q

Valvular carcinoma. If HPV related, what types?

A

Due to high-risk HPV typer 16 and 18

33
Q

Valvular carcinoma. risk factors to HPV related? what population?

A

HPV exposure due to multiple partners and early first age of intercourse. Occurs in women of reproductive age

34
Q

Valvular carcinoma. HPV related - arises from what?

A

Valvular intraepithelial neoplasia (VIN), a dysplastic precursor lesion characterized y koilocytic change, disordered cellular maturation, nuclear atypia, increased mitotic activity

35
Q

Valvular carcinoma. Non HPV related arises why?

A

due to long standing lichen sclerosis

36
Q

due to long standing lichen sclerosis?

A

Valvular carcinoma. Non HPV related

37
Q

Valvular intraepithelial neoplasia (VIN), a dysplastic precursor lesion characterized y koilocytic change, disordered cellular maturation, nuclear atypia, increased mitotic activity?

A

Valvular carcinoma. HPV related

38
Q

Valvular carcinoma. Non HPV related. population and what mechanism?

A

chronic inflammation and irritation eventually lead to carcinoma.
In elderly women (>70y/o)

39
Q

Extramammary paget disease. characterized?

A

Malignant epithelial cells in the epidermis of the vulva

40
Q

Extramammary paget disease. Presentation?

A

Erythematous, pruritic, ulcerated vulvar skin

41
Q

Erythematous, pruritic, ulcerated vulvar skin?

A

Extramammary paget disease.

42
Q

Extramammary paget disease. represents what?

A

Carcinoma in situ, usually with no underlying carcinoma.

43
Q

Extramammary paget disease. Paget disease of nipple is characterized by what?

A

malignant epithelial cells in the epidermis of the nipple, but is almos always associated with and underlying carcinoma.

44
Q

Extramammary paget disease. related to underlying carcinoma?

A

No

45
Q

What is related to underlying carcinoma?

A

Paget disease of nipple

46
Q

Extramammary paget disease. Distinguish from what?

A

melanoma, which rarely occur in vulva

47
Q

Paget cells what is staining? 3

A

PAS+, keratin+, S-100-

48
Q

Melanoma what is staining? 3

A

PAS-, keratin-, S-100+

49
Q

PAS+, keratin+, S-100-?

A

Paget cells

50
Q

PAS-, keratin-, S-100+?

A

Melanoma

1 STEP women patho (4 decks)

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