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1 STEP women patho > breast benign and cystic 01-20 > Flashcards

breast benign and cystic 01-20 Flashcards

1
Q

what 4 benign/fibrocystic changes?

A

fibrocystic change
intraductal papilloma
fobroadenoma
phylloides tumor

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2
Q
  1. Fibrocystic change. definition?
A

Development of fibrosis and cysts in the breast

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3
Q

Development of fibrosis and cysts in the breast?

A
  1. Fibrocystic change.
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4
Q
  1. Fibrocystic change. in what population?
A

most common change in the PREMENOPAUSAL breast; thought to be hormone mediated

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5
Q
  1. Fibrocystic change. presentation?
A

vague irregularity of the breast tissue (,lumpy breast’), usually in the upper outer quadrant

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6
Q
  1. Fibrocystic change. gross exam?
A

Cysts have BLUE-DOME appearance on gross exam

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7
Q

vague irregularity of the breast tissue (,lumpy breast’), usually in the upper outer quadrant?

A
  1. Fibrocystic change.
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8
Q
  1. Fibrocystic change. cancerous?
A

benign, but some changes are associated with increased risk for invasive carcinoma (increased risk applies for both breasts)

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9
Q
  1. Fibrocystic change. Which change does not increase risk for cancer?
A

fibrosis, cysts, and apocrine metaplasia

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10
Q
  1. Fibrocystic change. fibrosis, cysts, and apocrine metaplasia - risk for cancer?
A

no risk

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11
Q
  1. Fibrocystic change. what increases 2x risk for cancer?
A

Ductal hyperplasia and sclerosing adenosis

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12
Q
  1. Fibrocystic change. Ductal hyperplasia and sclerosing adenosis what risk for cancer?
A

2x risk

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13
Q
  1. Fibrocystic change. what increases 5x risk?
A

atypical hyperplasia

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14
Q
  1. Fibrocystic change.atypical hyperplasia what risk?
A

5x

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15
Q
  1. Intraductal papilloma. definition?
A

papillary growth, usually into a large duct

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16
Q

papillary growth, usually into a large duct?

A
  1. Intraductal papilloma.
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17
Q
  1. Intraductal papilloma. morphology?
A

fibrovascular projections lined by epithelial (luminal) and myoepithelial cells

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18
Q

fibrovascular projections lined by epithelial (luminal) and myoepithelial cells?

A
  1. Intraductal papilloma.
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19
Q
  1. Intraductal papilloma. presentation?
A

bloody nipple discharge in a PREmenopausal woman

20
Q

bloody nipple discharge in a PREmenopausal woman?

A
  1. Intraductal papilloma.
21
Q
  1. Intraductal papilloma. from what other must be distinguished?
A

papillary CARCINOMA, which also presents as bloody nippe discharge

22
Q
  1. Intraductal papilloma. diff. from papillary carcinoma?
A
  1. papillary carcinoma is characterized by fibrovascular projections lined by epithelial cells without underlying myoepithelial cells.
  2. Pap. carcinoma increases with age, thus more common in POSTmenopausal women.
23
Q
  1. Intraductal papilloma AKA papillary tumor
A

.

24
Q
  1. Fibroadenoma. definition?
A

Tumor of fibrous tissue and glands

25
Q

Tumor of fibrous tissue and glands?

A
  1. Fibroadenoma.
26
Q
  1. Fibroadenoma. prevalence and in what population?
A

most common benign neoplasm of the breast. seen in PREmenopausal women

27
Q

most common benign neoplasma of the breast?

A
  1. Fibroadenoma.
28
Q
  1. Fibroadenoma. presentation?
A

well-circumscribed, mobile, marble-like mass, painless

29
Q

well-circumscribed, mobile marble-like mass?

A
  1. Fibroadenoma.
30
Q
  1. Fibroadenoma. risk for cancer?
A

no risk

31
Q
  1. Fibroadenoma. sensitive to what?
A

estrogen sensitive - grows during pregnancy and may be painful during the menstrual cycle

32
Q

estrogen sensitive - grows during pregnancy and may be painful during the menstrual cycle?

A
  1. Fibroadenoma.
33
Q
  1. Phylloides tumor. morphology?
A

fibroadenoma-like tumor with overgrowth of the fibrous component.

34
Q
  1. Phylloides tumor. biopsy?
A

,,leaf-like” projections on biopsy

35
Q

,,leaf-like” projections on biopsy?

A
  1. Phylloides tumor.
36
Q
  1. Phylloides tumor. in what population?
A

POSTmenopausal women

37
Q
  1. Phylloides tumor. risk for malignancy?
A

can be malignant in some cases.

38
Q

UW. Fibroadenoma. Age?

A

15-35 (PREMENOPAUSAL)

39
Q

UW. Fibroadenoma. which side?

A

can occur as multiple/bilateral leasions

40
Q

UW. Fibroadenoma increase when?3

A

during pregnancy, lactation or with estrogen therapy

41
Q

UW. Fibroadenoma histology?

A

benign-appearing cellular or myxoid stroma that encircles epithelium-lined glandular and cystic spaces.

42
Q

benign-appearing cellular or myxoid stroma that encircles epithelium-lined glandular and cystic spaces?

A

Fibroadenoma

43
Q

UW. Mammary ductal ectasia. Histopathology?

A

Ductal dilation, breast secretion and CHRONIC granulomatous inflammarion in the periductal and interstitial areas.
Cells: PLASMA CELLS, lymphocytes, histiocytes, foamy macrophages (biski papildziau is pathology outlines)

44
Q

Ductal dilation, breast secretion and CHRONIC granulomatous inflammarion in the periductal and interstitial areas.
Cells: PLASMA CELLS, lymphocytes, histiocytes, foamy macrophages

A

UW. Mammary ductal ectasia.

45
Q

UW. Sclerosing adenosis - what is it?

A

fibrocytic change, that increases risk for invasive carcinoma 2x

46
Q

UW. Sclerosing adenosis histology?

A

Central acinar proliferation and compression with surrounding fibrotic tissue and peripheral ductal dilation.

47
Q

Central acinar proliferation and compression with surrounding fibrotic tissue and peripheral ductal dilation?

A

UW. Sclerosing adenosis

1 STEP women patho (4 decks)

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