Genital Systems Flashcards

1
Q

What are the 3 kidney systems and when do they form?

A
  1. pronephros– early in week 4
  2. mesonephos– when pronephros begins to regress
  3. metanephros – week 5 = permanent kidney
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2
Q

What forms the bowman’s capsule and glomerulus?

A

excretory tubules and tufts of capillaries => renal corpuscle

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3
Q

The tubules of the mesonepheric system enter a collecting duct called_______

A

mesonephric duct or wolffian duct

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4
Q

When do majority of the mesonephric ducts disappear?

A

end of 2nd month

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5
Q

describe the utereic bud

A

it is an outgrowth of mesonepheric tissue that penetrates the metanephric blastema. it is the collecting duct for this system and bud dilation results in a primitive renal pelvis –> splits into major calyces and then minor calyces

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6
Q

What structures come off the ureteric bud? (5)

A

ureter, renal pelvis, major and minor calyces, collecting tubules

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7
Q

What is a nephron

A

functional unit of the kidney (tubules and glomeruli)

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8
Q

When does urine production begin?

A

10th week

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9
Q

When are the kidneys fully functional?

A

12th week

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10
Q

What is the Urachus?

A

it is the obliterated lumen of the allantois that connects the bladder with the umbilicus

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11
Q

What does the urachus exist as in adults?

A

median umbilical ligament

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12
Q

Describe the epithelium change of the bladder

A

mesoderm is eventually replaced by endodermal epithelium

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13
Q

Wilm’s tumor is causd by what?

A

mutation in WTI gene

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14
Q

WAGR syndrome is a caused by what? What does WAGR stand for?

A

microdeletion on chromosome 11 –> involves PAX6 and WTI – Wilm’s tumor, Anirida, Gonadoblastoma, Retardation

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15
Q

Multicystic dysplastic kidney is caused by what? What structures fail to develop correctly?

A

GDNF mutation – nephron fails to develop and ureteric bud fails to branch, also renal agenesis

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16
Q

Autosomal recessive polycystic kidney disease is a mutation of what chromosome?

A

16.

17
Q

What is the difference between ARPKD and ADPKD?

A

ADPKD is more common but less progressive, chromosome 16 (85%) chromosome 4 (15%)

18
Q

Describe a horseshoe kidney.

A

Kidneys fused b/c they are close together, the IMA blocks their ascent

19
Q

When do germ cells arise from the epiblast?

A

week 2

20
Q

When do germ cells migrate to the yolk sac?

A

Week 3

21
Q

When do germ cells migrate to the dorsal mesentery of the hindgut?

A

week 5

22
Q

When do germ cells arrive at the genital ridge?

A

week 6

23
Q

Where does SRY gene come from what does it do?

A

it is on Y chromosome, it codes for testes-determining factor and causes maleness

24
Q

what is the purpose of the tunica albuginea?

A

seperates cords from surface epithelium

25
Q

When does differentiation of genital ducts and external genetalia begin?

A

week 8

26
Q

When do sertoli cells populate the cords?

A

week 16

27
Q

What structures does the mesonephric duct become?

A

epidiymal duct and vas deferens (seminal vesicles from out pocketing of the duct => ejaculatory ducts)

28
Q

What does the mullerian duct become/

A

prostatic utricle

29
Q

What is cryptorchidism?

A

failure of one or more testes to descend by birth

30
Q

When do the testes descend from lumbar to deep inguinal ring?

A

week 26

31
Q

In women what is the fate of the paramesonepheric ducts and wolffian ducts?

A

mullerian ducts –> uterus, uterine tubes, and fuse to form upper portion of vag. wolffian ducts degenerate

32
Q

What forms the hymen?

A

remnant of urogenital plate

33
Q

What does the femalephallus develop into?

A

glans clitoris, corpora cavernosus of the clitorus, vestibular bulb

34
Q

what does the phallus develop into in males?

A

glans penis, corpa cavernosa, corpus spongiosum

35
Q

What does the urethal folds develop into

A

labia minora (female) ventral aspect of penis ( males)

36
Q

What does the genital swelling develop into?

A

labia major and mons pubis in females, scrotom in males

37
Q

What is defective in hypospodias?

A

the urethral folds do not completely close => urethra openings on inferior side of penis