Genetics of cancer Flashcards
1
Q
List the 6 hallmarks of cancer
A
Evasion of apoptosis Self sufficiency in growth signals Insensitivity in anti-growth signals Tissue invasion and metastasis Sustained angiogenesis Limitless replicative potential
2
Q
Name the two classes of genes that cancer causing mutations commonly occur in
A
Oncogenes
Tumour suppressor genes
3
Q
Give an example of a tumour suppressor gene
A
P53
4
Q
Give an example of an oncogene
A
ras
5
Q
What do oncogene mutations cause
A
Gain of function
6
Q
What do tumour suppressor mutations cause
A
Loss of function
7
Q
List the 3 types of autosomal dominant colorectal cancer syndromes
A
Lynch (Hereditary non-polyposis colorectal cancer)
Familial adenomatous polyposis
Peutz-jeghers syndrome
8
Q
List the three gene mutations associated with breast cancer
A
BRCA1
BRCA2
TP53
9
Q
What other cancers are associated with lynch syndrome
A
Endometrial Ovarian Urinary tract Stomach Small bowel Hepatobiliary
