Genetics Exam 3 Flashcards
Operator
a DNA sequence that binds a regulatory protein
Promoter
a DNA sequence that binds RNA polymerase and regulates transcription
Corepressor
a compound that interacts with another protein or compound to form an active repressor
Inducer
a compound that induces or activates transcription, such as lactose
Repressor
a regulatory protein that may bind DNA to inhibit transcription
allostery
a process by which the stereochemistry of a protein is altered to change its interaction capabilities
attentuation
a mechanism of transcriptional regulation in which transcription level is modified to meet environmental requirements
negative regulation
a process of transcriptional regulation through which binding of regulatory proteins to DNA blocks transcription
positive regulation
a process of transcription regulation through which the binding of regulatory proteins to DNA activates transcription
what pattern of chromatin modification would activate transcription to the greatest extent?
increased acetylation and decreased methylation of histones
Gal4 is mutated such that it still binds to the DNA but cannot interact with Gal80. What effect on transcription would you expect to see in the absence of galactose?
transcription will be activated
where are CpG islands clustered in mammalian genomes?
promoters
Dicer activity does what?
Cleaves dsRNA molecules into 21-25 bp fragments
enhancer
DNA sequence that binds regulatory proteins that interact with promoter bound proteins to activate transcription
silencer
a DNA sequence that binds regulatory proteins that inhibit transcription
