genetics

Question 1

AML

Answer 1

APL: t (15;17)

Question 2

CML

Answer 2

philadelphia chr - t (9;22), BCR-ABL

Question 3

hairy cell leukemia (low grade)

Answer 3

BRAF

Question 4

T-cell/ ALL

Answer 4

t(12;21)= better prognosis» philadelphia chr t(9;22)= worse prognosis

TdT + (pre-t/b-cell); CD10+(pre-b-cell)

Question 5

Hodgkin Lymphoma

Answer 5

CD15, CD30+

Question 6

Burkitt lymphoma

Answer 6

t (8;14) - translocation of c-myc (8) and heavy chain Ig (14)

Question 7

diffuse B cell lymphoma

Answer 7

mutations in BCL-2, BCL-6

Question 8

follicular lymphoma

Answer 8

t (14;18)- translocation of heavy chain Ig (14) and BCL-2 (18)

Question 9

mantle cell lymphoma

Answer 9

t (11; 14) - translocation of cyclin D1 (11) and heavy chain Ig (14), CD5+

Question 10

marginal zone lymphoma

Answer 10

t(11; 18)

Question 11

primary CNS lymphoma

Answer 11

EBV related; associated w/ HIV/ AIDS

Question 12

Adult T cell Lymphoma

Answer 12

Human T cell lymphocytic virus type 1 (HTLV-1)

Question 13

Mycosis fungoides/Sezary syndrome

Answer 13

mycosis fungoides; atypical CD4+ cells w/ cerebriform nuclei and intraepidermal neoplastic cell aggregates (pautrier microabscess)