autoantibodies

Question 1

Myasthenia gravis (gets worse throughout the day)

Answer 1

anti-POSTsynaptic AChR

Question 2

LEMS- Lambert-Eaton Myasthenic syndrome (gets better as day goes on)

Answer 2

anti- PREsynaptic voltage-gated calcium channel

Question 3

Antiphospholipid syndrome

Answer 3

Anti-B2 glycoprotein I

Question 4

non-specific screening antibody, often assoc w/ SLE

Answer 4

ANA- antinuclear

Question 5

SLE (specific)

Answer 5

anti-Smith; anti-dsDNA

Question 6

Drug-induced Lupus

Answer 6

anti-histone

Question 7

Mixed CT disease

Answer 7

Anti-U1 RNP (ribonucleoprotein)

Question 8

RA

Answer 8

RF (IgM antibody against IgG Fc region)

anti-CCP (more specific)

Question 9

Sjogren syndrome

Answer 9

Anti- Ro/SSA

Anti-La/SSB

Question 10

Diffuse Scleroderma/ systemic sclerosis

Answer 10

anti-Scl-70 (anti-DNA topoisomerase I)

Question 11

Limited- Scleroderma (CREST-syndrome)

Answer 11

Anticentromere

Question 12

polymyositis, dermatomyositis

Answer 12

anti-synthetase (anti-Jo-1)
anti-SRP
anti- helicase (anti-Mi-2)

Question 13

primary biliary cholangitis

Answer 13

antimitochondrial

Question 14

AI hepatitis type 1

Answer 14

anti-Smooth muscle

Question 15

microscopic polyangiitis; eosinophilic granulomatosis w/ polyangiitis (Churg Strauss syndrome), Ulcerative colitis

Answer 15

MPO-ANCA (AKA. p-ANCA)

—Perinuclear anti-neutrophil cytoplasmic antibodies

Question 16

GPA (Wegener)

Answer 16

PR3-ANCA (AKA. c-ANCA)

—cytosolic- anti-neutrophil cytoplasmic antibodies

Question 17

primary membranous nephropathy

Answer 17

anti-phospholipase A2 receptor

Question 18

Bullous pemphigoid

Answer 18

Anti-hemidesmosome (Basement Membrane)

Question 19

Pemphigus vulgaris

Answer 19

anti-desmoglein3 (desmosomes between keratinocytes and in stratum spinosum)

Question 20

Hashimoto thyroiditis

Answer 20

anti-thyroglobulin

anti-TPO (antimicrosomal)

Question 21

Graves disease

Answer 21

anti-TSH, TSI

Question 22

celiac disease

Answer 22

IgA anti-endomysial
IgA anti-tissue transglutaminase
IgA and IgG deamidated gliadin peptide

Question 23

Type 1 DM (type III HSR)

Answer 23

anti-glutamic acid decarboxylase

islet cell cytoplasmic antibodies

Question 24

pernicious anemia

Answer 24

anti-parietal cell (won’t produce IF)

anti-IF (attacks IF) –> no vit B12 absorption –> megaloblastic macrocytic anemia

Question 25

goodpasture syndrome

Answer 25

anti-GBM –> RPGN, hemoptysis, hematuria