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USMLE step 1 > autoantibodies > Flashcards

autoantibodies Flashcards

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USMLE® Step 1 flashcards
1
Q

Myasthenia gravis (gets worse throughout the day)

A

anti-POSTsynaptic AChR

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2
Q

LEMS- Lambert-Eaton Myasthenic syndrome (gets better as day goes on)

A

anti- PREsynaptic voltage-gated calcium channel

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3
Q

Antiphospholipid syndrome

A

Anti-B2 glycoprotein I

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4
Q

non-specific screening antibody, often assoc w/ SLE

A

ANA- antinuclear

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5
Q

SLE (specific)

A

anti-Smith; anti-dsDNA

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6
Q

Drug-induced Lupus

A

anti-histone

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7
Q

Mixed CT disease

A

Anti-U1 RNP (ribonucleoprotein)

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8
Q

RA

A

RF (IgM antibody against IgG Fc region)

anti-CCP (more specific)

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9
Q

Sjogren syndrome

A

Anti- Ro/SSA

Anti-La/SSB

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10
Q

Diffuse Scleroderma/ systemic sclerosis

A

anti-Scl-70 (anti-DNA topoisomerase I)

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11
Q

Limited- Scleroderma (CREST-syndrome)

A

Anticentromere

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12
Q

polymyositis, dermatomyositis

A

anti-synthetase (anti-Jo-1)
anti-SRP
anti- helicase (anti-Mi-2)

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13
Q

primary biliary cholangitis

A

antimitochondrial

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14
Q

AI hepatitis type 1

A

anti-Smooth muscle

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15
Q

microscopic polyangiitis; eosinophilic granulomatosis w/ polyangiitis (Churg Strauss syndrome), Ulcerative colitis

A

MPO-ANCA (AKA. p-ANCA)

—Perinuclear anti-neutrophil cytoplasmic antibodies

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16
Q

GPA (Wegener)

A

PR3-ANCA (AKA. c-ANCA)

—cytosolic- anti-neutrophil cytoplasmic antibodies

17
Q

primary membranous nephropathy

A

anti-phospholipase A2 receptor

18
Q

Bullous pemphigoid

A

Anti-hemidesmosome (Basement Membrane)

19
Q

Pemphigus vulgaris

A

anti-desmoglein3 (desmosomes between keratinocytes and in stratum spinosum)

20
Q

Hashimoto thyroiditis

A

anti-thyroglobulin

anti-TPO (antimicrosomal)

21
Q

Graves disease

A

anti-TSH, TSI

22
Q

celiac disease

A

IgA anti-endomysial
IgA anti-tissue transglutaminase
IgA and IgG deamidated gliadin peptide

23
Q

Type 1 DM (type III HSR)

A

anti-glutamic acid decarboxylase

islet cell cytoplasmic antibodies

24
Q

pernicious anemia

A

anti-parietal cell (won’t produce IF)

anti-IF (attacks IF) –> no vit B12 absorption –> megaloblastic macrocytic anemia

25
Q

goodpasture syndrome

A

anti-GBM –> RPGN, hemoptysis, hematuria

USMLE step 1 (14 decks)

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