Genetic linkage mapping

Question 1

What does SNP stand for

Answer 1

Single Nucleotide Polymorphisms

Question 2

What is genetic mapping

Answer 2

describes the methods used to identify the locus of a gene and the distances between genes.

Question 3

What are genetic markers

Answer 3

detectable sequences in the DNA that are inherited along with a disease gene

Question 4

Recombination frequency

Answer 4

Depends on the distance between genes on the chromosomes

Question 5

What is genetic mapping based on

Answer 5

recombination frequencies

Question 6

Distinguish between linked genes, unlinked genes and sex-linked genes

Answer 6

Linked genes
If two genes are located close together on the same chromosome, they do not segregate independently therefore inherited together
Unlinked genes
may be on different chromosomes, or so far apart on the same chromosome that they are often separated by recombination
Sex-linked genes
Genes that are carried by either sex chromosome

Question 7

Explain what it is meant by single nucleotide polymorphism and how SNP’s can be used as genetic markers for finding genes associated with disease phenotypes

Answer 7

Single base pair differences in the sequences of a particular region of DNA from one individual compared to another of the same species or population
Used as molecular markers to find genes associated with a specific phenotype