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Genes and chromosomes Flashcards

meiosis and mitosis

1
Q

what is heredity

A

the transmission of traits from one generation to the next

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2
Q

what is genetics

A

the scientific study of heredity and inherited variation

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3
Q

what are reproductive cells called

A

gametes

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4
Q

what do gametes do

A

they are reproductive cells that transmit genes from one generation to the next

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5
Q

what are the male and female gametes

A

sperm and eggs

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6
Q

where is DNA found in eukaryotes

A

in the nucleus, mitochondria and chloroplast

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7
Q

humans have ….. chromosomes in their somatic cells

A

46

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8
Q

what are somatic cells

A

all the cells of the body except from gametes and their precursors

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9
Q

what does each chromosome consist of

A

a single DNA molecule coiled in association with various proteins

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10
Q

what is a DNA molecule divided into

A

genes

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11
Q

what is the locus of a gene

A

the gene’s location along the length of the chromosome

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12
Q

what kind of reproduction produces offspring that are an exact copy of the parent

A

asexual reproduction

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13
Q

what happens in asexual reproduction

A

a single organism passes all of its genes to offspring without the fusion of gametes (gives rise to a clone)

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14
Q

how may differences arise in asexually reproducing organisms

A

either by mutation or error in cell division

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15
Q

what happens in sexual reproduction

A

two parents give rise to offspring that have unique combinations of genes inherited form the two parents
offspring vary genetically from siblings and parents

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16
Q

what is a life cycle

A

the generation to generation sequence of stages in the reproductive history of an organism from conception to production of its own offspring

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17
Q

when chromosomes become condensed for mitosis what characteristics can we analyse

A
  • size
  • position of centromeres
  • patterns of coloured bands produced by certain chromatin binding stains
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18
Q

what is a karyotype

A

a display of chromosomes in their 23 pairs

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19
Q

what is the same in the 2 chromosomes of a pair

A
  • length
  • centromere position
  • staining pattern
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20
Q

what are the pairs of chromosomes called

A

homologous chromosomes

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21
Q

both chromosomes of each homologous pair carry genes controlling the same ………………………

A

inherited characteristics

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22
Q

are the X and Y chromosomes homologous

A

not fully - only small parts are homologous

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23
Q

what kind of chromosomes are the X and Y chromosomes

A

sex chromosomes

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24
Q

what are all the other chromosomes that are not sex chromosomes called

A

autosomes

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25
Q

how many chromosomes of a pair do we inherit from each parent

A

one

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26
Q

what is the number of chromosomes in a single set represented by

A

n

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27
Q

what is a diploid cell

A

any cell with two chromosomes

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28
Q

what is the abbreviation for a diploid number of chromosomes

A

2n

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29
Q

what is the diploid number of chromosomes for humans

A

2n = 46

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30
Q

once DNA synthesis has occurred each chromosome contains 2 what

A

sister chromatids

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31
Q

is a cell still diploid once DNA has been synthesised

A

yes - even though the chromosomes are duplicated the cell is still diploid because it only has 2 sets of information regardless of the number of chromatids (the chromatids are merely copies of the information in one set)

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32
Q

which cells are haploid

A

gamete cells

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33
Q

what is the haploid chromosome number for humans

A

n = 23

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34
Q

what does the set of 23 chromosomes consist of

A

22 autosomes and a single sex chromosome

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35
Q

an unfertilised egg contains which sex chromosome

A

X

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36
Q

a sperm contains which sex chromosome

A

either and X or a Y

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37
Q

when does the human life cycle begin

A

when the haploid sperm of the father fuses with the haploid egg of the mother

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38
Q

the fusion of the nuclei of gametes is called what

A

fertilisation

39
Q

what is the result of fertilisation and is it haploid or diploid

A

zygote - diploid - because it contains 2 haploid sets of chromosomes

40
Q

how are the somatic cells of the body generated from the zygote

A

mitosis of the zygote and its descendant cells generates all the somatic cells

41
Q

what are the only cells of the human body not produced by mitosis

A

the gametes

42
Q

what cells do gametes develop from

A

the germ cells in the gonads (ovaries or testes)

43
Q

gamete division involves which type of cell division

A

meiosis

44
Q

meiosis reduces the number of sets of chromosomes from 2 to 1 combating the doubling that occurs in which process

A

fertilization

45
Q

describe the alternation of generations life cycle that plants and algae exhibit

A

includes both diploid and haploid stages that are multicellular

  • the multicellular diploid stage is called sporophyte
  • meiosis in the diploid stage produces haploid cells called spores
  • haploid cell divides mitotically, generating a multicellular haploid stage called the gametophyte (an organism)
  • these gametophytes give rise to gametes by mitosis
  • fusion of 2 haploid gametes results in diploid zygote
  • the zygote develops into the next sporophyte generation
46
Q

describe the animal life cycle

A

gametes are the only haploid cells

  • meiosis occurs in germ cells during the production of gametes
  • gametes undergo no further cell division prior to fertilization
  • after fertilization the diploid zygote divides by mitosis producing a multicellular organism that is diploid
47
Q

describe the life cycle seen in most fungi and some protists

A

the only diploid stage is the single celled zygote
- gametes fuse and form a diploid zygote
- meiosis occurs with a multicellular diploid offspring developing
- meiosis produces not gametes but haploid cells
- these cells then divide by mitosis and give rise to either unicellular descendants or haploid multicellular adult organism
the haploid organism carries out further mitosis producing cells that develop into gametes

48
Q

can haploid and diploid cells undergo mitosis

A

yes

49
Q

can haploid and diploid cells undergo meiosis

A

no - only diploid cells can undergo mitosis because haploid cells only have a single set of chromosomes that cannot be further reduced

50
Q

what happens before both meiosis and mitosis

A

chromosomes are duplicated

51
Q

how many cells does meiosis result in

A

4 haploid cells

52
Q

how many cells does mitosis result in

A

2 diploid cells

53
Q

what are sister chromatids

A

2 copies of one chromosome closely associated - sister chromatid cohesion

54
Q

what do sister chromatids make up

A

one duplicated chromosome

55
Q

what do homologous chromosomes contain

A

individual chromosomes that were inherited from each parent - they look alike but have different versions of genes at corresponding loci with each version being called an allele

56
Q

what are the steps of prophase I

A

prophase I (duplicated chromosomes pair up and exchange segments)

  • spindle formation and nuclear membrane breakdown
  • chromosomes start to condense
  • each duplicated chromosome pairs with its homolog and crossing over occurs (DNA form non-sister chromatids are broken and re-joined to each other
  • duplicated homologous chromosomes pair up and exchange segments
  • each homologous pair has chiasmata where crossing over has occurred
  • microtubules from the poles attach to the kinetochores (found at the centromere of each homolog)
  • microtubules move homologous pairs towards the metaphase plate
57
Q

what are the steps of metaphase I

A

metaphase I (chromosomes line up by homologous pairs)

  • pairs of homologous chromosomes are now arranged at the metaphase plate with one chromosome of each pair facing each pole
  • both chromatids of one homolog are attached to kinetochore microtubules from the pole they are facing
58
Q

what are the steps in anaphase I

A

anaphase I (two homologous chromosomes of each pair separate)

  • breakdown of sister chromatid cohesion proteins allows homologs to separate
  • homologs move towards separate poles as directed by spindle apparatus
  • sister chromatid cohesion persists at the centromere causing chromatids to move as a unit towards the same pole
59
Q

what are the steps in telophase I and cytokinesis

A

telophase I and cytokinesis (2 haploid cells form, each chromosome still consists of 2 sister chromatids)

  • each half of the cell has a complete haploid set of duplicated chromosomes
  • each chromosome is composed of 2 sister chromatids and one or both chromatids contain non-sister DNA
  • cytokinesis (division of the cytoplasm) usually occurs simultaneously with telophase I forming 2 haploid daughter cells
60
Q

does chromosome duplication occur between meiosis I and meiosis II

A

NOOOO

61
Q

what are the steps in prophase II

A

prophase II

  • spindle apparatus forms
  • chromosomes each still composed of 2 chromatids associated at the centromere are moved by microtubules towards the metaphase plate
62
Q

what are the steps of metaphase II

A

metaphase II

  • chromosomes are positioned at the metaphase plate
  • because of crossing over in meiosis I the 2 sister chromatids of each chromosome are not genetically identical
  • the kinetochores of sister chromatids are attached to the microtubules extending from the poles
63
Q

what are the steps of anaphase II

A

anaphase II

  • breakdown of proteins holding sister chromatids together at centromere allows chromatids to separate
  • the chromatids move towards opposite poles as individual chromosomes
64
Q

what are the steps in telophase II and cytokinesis

A

telophase II and cytokinesis

  • nuclei form and chromosomes begin decondensing
  • cytokinesis occurs
  • the result is 4 daughter cells each with a haploid set of unduplicated chromosomes
  • the four cells are genetically distinct from each other and the parent cell
65
Q

what are the 4 steps in the cell cycle

A
  • G1 - growth
  • S - DNA synthesis
  • G2 - growth
  • M - mitosis
66
Q

after interphase (g1, S, g2) the chromosomes have been duplicated and the sister chromatids are held together by what proteins

A

cohesins

67
Q

in prophase I when the DNA molecules of 2 non-sister chromatids breaks at corresponding points what happens to the chromatin

A

it starts to condense

68
Q

what is the synaptonemal complex

A

it holds one homolog tightly to the other in prophase I

69
Q

what happens during synapsis in prophase I

A

the DNA breaks are closed up so that each broken end is joined to the corresponding segment of the non-sister chromatid (a paternal chromatid is joined to a piece of the maternal chromatid beyond the crossover point and vice versa)

70
Q

what do the points of crossing over become visible as

A

chiasmata

71
Q

what happens in prophase of mitosis

A
  • chromatin fibres become tightly coiled
  • nucleoli disappear
  • each duplicated chromosome appears as 2 identical sister chromatids joined at their centromeres
  • the spindle apparatus begins to form (spindle fibres extend from the centrosomes and shorter microtubules extend from asters)
  • centrosomes move to opposite poles
72
Q

what happens in the prometaphase of mitosis

A
  • nuclear envelope fragments
  • the chromosomes have become more condensed
  • a kinetochore has formed at the centromere of each chromatid (2 per chromosome)
  • microtubules attach to kinetochores
  • non-kinetochore microtubules interact with the opposite pole lengthening the cell
73
Q

what happens in the metaphase of mitosis

A
  • chromosomes have all arrived at the metaphase plate (their centromeres lie at the metaphase plate)
  • the kinetochores of the 2 sister chromatids are attached too opposite poles
74
Q

what happens in the anaphase of mitosis

A
  • shortest stage
  • cohesion proteins are cleaved, parting sister chromatids and each chromatid becomes an independent chromosome
  • chromosomes move to poles as kinetochore microtubules shorten
  • the cell elongates as the non-kinetochore microtubules lengthen
75
Q

what happens in telophase of mitosis

A
  • 2 daughter nuclei form in the cell and nuclear envelopes arise
  • nucleoli reappear
  • chromosomes become less condensed
  • any remaining spindle microtubules depolymerise
76
Q

what happens during cytokinesis

A
  • happens in late telophase
  • the cytoplasm divides
  • involves the formation of a cleavage furrow that pinches the cell in 2
77
Q

what is the cleavage furrow

A

a shallow groove in the cell surface near the old metaphase plate
on the cytoplasmic side of this is a contractile ring of actin filaments associated with myosin
interaction between actin and myosin cleaves the cell in 2

78
Q

in interphase what happens to the centrosome

A

it duplicates

79
Q

what is the main difference between meiosis and mitosis

A

meiosis reduces the number of chromosome sets from 2 to 1 whereas mitosis conserves the number of chromosome sets whether this be 2 or 1

80
Q

which 3 events are unique to meiosis

A
  1. synapsis and crossing over (prophase I)
  2. alignment of homologous pairs at the metaphase plate (metaphase I) (rather than individual chromosomes in mitosis)
  3. separation of homologs (in mitosis sister chromatids separate) (anaphase I)
    (these all occur in meiosis I)
81
Q

in what steps of meiosis and mitosis are cohesions cleaved

A

mitosis - metaphase (cohesion at centromere - allows sister chromatids too separate)
meiosis - anaphase I (cohesion at arms - allows homologs to separate) and anaphase II (cohesion at a centromere - allows sister chromatids to separate)

82
Q

mitosis is pretty much identical to meiosis I/II

A

meiosis II

83
Q

shuffling of alleles during sexual reproduction produces …………..

A

variation

84
Q

each member of a sexually/asexually reproducing population have a unique combination of traits

A

sexually

85
Q

what 3 mechanisms contribute to genetic variation from sexual reproduction

A

independent assortment
crossing over
random fertilization

86
Q

what is independent assortment

A

the random orientation of pairs of homologous chromosomes at metaphase of meiosis I

  • at metaphase I homologous chromosomes each consisting of one maternal and one paternal chromosome are situated in the metaphase plate
  • each pair may orient with either its paternal or maternal homolog closer to a given pole
  • 50% chance that daughter cells of meiosis I will get paternal/maternal chromosome of a certain homologous pair
87
Q

what is crossing over and how does it contribute to variation

A

crossing over produces recombinant chromosomes - individual chromosomes that carry genes from 2 different parents. it produces new combinations of maternal and paternal alleles

88
Q

how does random fertilisation contribute to increased variation

A

it adds to the genetic variation arising from meiosis

89
Q

what is the original source of different alleles

A

mutation

90
Q

what are the differences between sexual and asexual reproduction

A 
sexual 
- requires a lot of energy investment 
- fusion of gametes
- allows variation 
asexual 
- requires less energy 
- no fusion of gametes 
- no variation - clones
91
Q

are germ cells haploid or diploid

A

diploid

92
Q

what is epigenetics

A

the study of the chemical modification of specific genes or gene-associated proteins of an organism

93
Q

give an examples of an epigenetic tag

A

methylation - influences the level of transcription

B (19 decks)

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