General Principles - Systemic Pharm

Question 1

Acidification or urine increases ionization of weak bases and increases renal elimination. True or false?

Answer 1

True

Question 2

4 steps in drug cycle (pharmacokinetics)

Answer 2

Absorption, distribution, metabolism, excretion

Question 3

Increased GI motility decreases drug absorption. True or false?

Answer 3

True

Question 4

Most drug metabolism occurs in the

Answer 4

Liver

Question 5

Grapefruit juice can raise drug levels of CCB because it decreases metabolism of drug by inhibiting intestinal isoenzyme ____.

Answer 5

CYP3A4

Question 6

MAO inhibitors taken w/ tyramine-rich foods (cheese, wine, organ meats, beer, yogurt) may lead to

Answer 6

Hypertensive crisis

Question 7

___ order elimination rate falls as plasma level falls.

Answer 7

First

Question 8

A constant amount of drug is eliminated per unit time

Answer 8

Zero order elimination rate

Question 9

Drug absorption decreases w/ food binding. Give one example.

Answer 9

Tetracycline and dairy

Question 10

Factors affecting response to meds

Answer 10

Age, body fat, body water, body proteins

Question 11

OTC cold and cough meds stimulate ___ and should not be taken w/o doctor approval in pts w/ …

Answer 11

Sympathetic nervous system

Heart dx, HTN, thyroid dx

Question 12

Elimination of drugs is reduced as a result of reduced hepatic blood flow and predisposal to toxicity in pts w/ ___ failure.

Answer 12

Heart

Question 13

Renal dx results in chronic renal failure, reduced excretion, drug absorption, distribution, and metabolism. True or false?

Answer 13

True

Question 14

Liver dx results in

Answer 14

Reduced metabolism -> toxicity