General pathophysiology - hematologic disorders Flashcards
What is the most common erythrocyte disorder?
anemia
splenic contraction causes
rapid changes in RBC distribution by releasing a concentrated bolus of stored RBCs.
what do Cold hemagglutinin disease, Blood parasites and methemoglobinemia have in common?
they all cause hemolytic anemia
Hydration status is usually evaluated by considering
plasma protein (PP) concentration and PCV in combination.
2 main points for completing an anemia diagnosis
- determine the severity of the anemia
- determine the boen marrow responsiveness
a mild anemia in a dog is how much?
over 30% PCV but under species norm
a mild anemia in a cat is how much?
over 20% but under species norm
In what 4 situations would no reticulocytosis or polychromasia be expected
- no anemia, blood normals
- nonregenerative anemia
- during the first 2-3 days of onset of regenerative anemia
- during a mild anemia which will not stimulate much reticulocytosis
Reticulocytosis and polychromasia peak when?
4-5 days after onset of anemia if bone marrow function is normal
how much is marked canine reticulocytosis?
> 500,000 /ul
how much is marked feline reticulocytosis?
> 200,000 /ul
What diagnostic tool/result is best proof of intravascular hemoolytic anemia?
hemoglobinuria
Reticulocyte quantitation in blood is the most consistent way to evaluate what?
the strength of erythropoiesis
but time after onset and magnitude of reticulocytosis must be considered in conjunction
a reticulocyte count should be performed when the pcv is less than how much in dogs?
30%
so a moderate or severe anemia
a reticulocyte count should be performed when the pcv is less than how much in cats?
20%
so a moderate or severe anemia