General notes Flashcards
Explain risks of breast cancer in woman taking HRT
Low with oestrogen only
Name risks associated with HRT
Breast cancer
Endometrial cancer
VTE
Stroke / CVD
Who do the risks of HRT not apply to
Women < 50 years old
No increased CVD risk with oestrogen only HRT
Who do you not give HRT to
Women > 60 years old
Risks outweigh benefits
Name 5 CI to HRT
Undiagnosed endometral bleeding
Endometrial cancer
Breast cancer
Uncontrolled HTN
VTE
Active angina or MI
Pregnancy
How long is the Mirena coil licensed for endometrial protection
4 years
When is the risk of stroke / CAD increased
If taken > 10 years after menopause - combined
How is the risk of breast cancer affected by stopping HRT
Declines once stopped and normal in 5 years
Name 5 adverse effects of antimuscarinics
Confusion
Dry mouth
Tachycardia
Dilated pupil
Loss of accommodation
What occurs if Methotrexate and Trimethoprim are co-prescribed
Pancytopenia
Neutropenic sepsis
Name the presentation and ECG signs for Hypercalcameia
Renal stones
Bone pain
Abdominal groans
Psychiatric overtones
Short QT interval
What medications should be cautioned in patients taking Methotrexate
PPI
NSAIDs
Ibuprofen - risk of nephrotoxicity
Name the adverse effects of anticholinergics
cosntipation
dry mouth
blurred vision
urinary retention
Name 3 anticholinergic drugs
Oxynutinin
Atropine
Tiotropium
Name 3 drugs that effect lithium excretion
ACEi
Diuretics
NSAIDs
Name 5 drugs causing agranulocytosis
Carbamazepine
Name 5 drugs causing agranulocytosis
Carbamazepine
clozapine
colchicine
carbimazole
Which opioids are safe in CKD
Oxycodone
alfentanil
fentanyl
Name 5 drugs that cause C.diff infection
PPI
Clindamycin
Co-amox
CIprofloxacin
Cephalosporin
Name drugs that prolong QTc
A - Antidepressants (SSRI / TCA)
A - Antipsychotics
A - Antibiotics
A - Anti arrhythmics
A - Antifungals
A - Antiemetics
D - Diuretics
What is the minimum treatment length with steroids to require prophylactic bisphosphonates
3 months
How do you assess the response to Abx in penumonia
1 - O2 stats / ABG
2 - Resp rate
What are the contraindications to the COCP
Breastfeeding and <6 post partum
Migraine with aura
>35 and smoking >15/day
VTE
Active cancer