General neurology [29/10/20] Flashcards
4 key features of Parkinson’s disease
Bradykinesia, rigidity, postural instability, tremor
Parkinsonism cauases
- idiopathic PD
- vascular Parkinsonism
- normal pressure hydrocephalus
- Parkinson’s plus syndrome [PPS]
- iatrogenic
Typical preparation of L-dopa for PD
- Co-careldopa/ co-beneldopa [L-dopa given with a dopa-decarboxylase]
- CR prep
- dispersable prep [rescue/morn.]
- can have Statevo which is co-careldopa plus etacapone [etacapone helps stop breakdfown of L-dopa and is a COMT inhibitor]
Dopamine agonists available, and their advantage over L-dopa
- non-ergot [Ropinirole, Pramiexole, Rotigotine]
- ergot [Bromotcriptine etc.]
- adv: less dyskinesia, longer acting
- dis: higher risk hallucinations, compulsive behaviour, postural hypotension, daytime sleepiness, specific ergot SE like fibrosis lungs/chest so need constant monitoring ECG/CT
Examples of MAOI and cautions related to them
- Selegiline, Rasagiline.
- Serotonin syndrome: pyrexia, agitation, sweating, diarrhoea
- Tramadol, Dethidine, MTX are CI
When to start drug treatment for PD?
No disadvantage starting early, generally for Sx control [esp. L-dopa best for that]
Non-motor Sx of PD
Mood, sleep [esp. REM sleep], cognitive, impulse control disorder, autonomic dysfunction, anosmia [pts can have Sx for 20y without Dx]
REM sleep disorder: pts acting out their dreams.
Insomnia due to stiffness/restlessness
Psychotic PD Tx
- assess provoking factors [could be illness, metabolic, infection]
- refer to neuro
- disconintue meds like MAOI
- intitiate clozapine, quitiepine [consider acetylcholine esterase inhibitors]
Autonomic Sx PD
orthostatic hypotnesion, N and vomiting, hypersalivation, nocturia, sweating etc.
When can DBS be used for PD and what is the benefit?
used in the subthalamic nucleus, lowers requirement for L-dopa [by about half its dose]
- only for pts with motor fluctutations
Sx of a third nerve palsy
Parasympethic fibres
Apex petrous part temporal bone
Fixed dilated pupil
Sx of cerebellar syndrome
Ataxia, nystagmus
ipsilateral
Midraib, pons, medulla
What is above and below the brain stem?
Above: thalamus, internal capsule
Below: spinal cord
Describe the reticulating activating system and its function
Peri-aqueductal grey matter/ floor of the 4th ventricle
->
alertness, sleep/awake, REM/nonREM sleep, resp control, CV drive
Disorders affecting the brainstem
Tumour [meningioma, schwanomma, mets etc,], inflammation [MS], metabolic, trauma, Haemorrhage [AVM, aneurysm], infarct [vertebral artery infarct], infection [cerebellar in ear]
What is compensated type 2 respiratory failure?
High CO2, normal or low O2, high bicarb [to compensate]
Mx of acute neuromuscular respiratory weakness
- ABCD
- ABG
- ECG
- supportive Mx respiratory and autonomic instability
- early anaesthetic call
- consider infection
- Tx underlying condition
How to investigate MG?
- consider culprit [drugs like Mebeverine]
- bloods for ACh receptor antibodies [MuSK]: 85% positive [though takes 3w]
- thyroid function [autoimmune coexistence]
- CT chest [possible thymoma]
- if antibodies there: simple fibre EMG [NM] dysfunction
Mx of generalised MG
- assess severity
- caution Rx [stop Mebeverine]
- Pyridostigmine 30mg qid inc. to 60 qid and higher [max 450mg per day]
- steroids 10mg al days increasing by 10mg after 3rd dose aiming for 100mg alt days [quicker if IP, beware dips]
- bone protection, PPI
- IVIg
- Tx infections early, aggressively and care with antibiotics
- LARGE list of drugs CI in MG patients
What is a typical pyramidal [or UMN] pattern of weakness?
- Flexors > extensors in UL
- Extensors > flexors in LL
- consequently, pt circumducts leg to walk as cannot flex hip properly to take step
Ix for pt with back pain, difficulty walking, pyramidal weakness
- MRI cervical spine [possible compression], LP, admit and observe = DONE IMMEDIATELY
- [NCS, anti-glioside antibodies, infection serology for cause]
Mx of GBS
IVIg, monitor pulse and BP, monitor FVC
Autonomic instability Mx for GBS
- tachycardia: drugs/DC cardioversion
- bradycardia: drugs/pacing
- HTN: labetolol
- hypotension: fluids, inotropics
Mx of respiratory failure in MND
Care with O2, consider infection, NIV on ward, ITU usually not appropriate