General Lymphoma

Question 1

What is the CD Marker for a stem cell?

Answer 1

CD34

Question 2

What are the markers for Granulocyte, monocytes, T-lymphocyte, B-lymphocyte, thrombocytes?

Answer 2

Granulocyte = CD45/CD15
Monocytes = CD45/CD14

T-Lymphocyte = CD45/CD3
B-Lymphocyte = CD45/CD19

Thrombocytes = CD45/CD61

Question 3

What are the CD markers for Helper T-Lymphocyte, Cytotoxic T-Lymphocyte and Activated T-Lymphocyte?

Answer 3

Helper T-Lymphocyte = CD45/CD3/CD4
Cytotoxic T-Lymphocyte = CD45/CD3/CD8

Activated T-Lymphocyte = CD45/CD3/CD25

Question 4

What are the CD markers for B Lymphocyte?

Answer 4

CD45/CD19/CD20
CD24/CD22
CD38

Question 5

What are the CD Markers for NK cell?

Answer 5

CD15
CD56
CD31, CD30, CD38
CD3-

Question 6

How often is the bone marrow involved in lymphoma?

Answer 6

40% Low-grade
40% Intermediate-grade
20% High-grade lymphomas

Question 7

How often does HBV Reactivation occur with cytotoxic chemotherapy ?

Answer 7

20-50% with HBsAg +

3-45% with HBcAb +

Question 8

What lymphoma is Hep C associated with?

Answer 8

NHL, esp B Cell lymphomas

Question 9

Tell me about the 5-point scale and PET-CT

Answer 9

The 5-PS is based on the visual assessment of FDG uptake in involved sites relative to the mediastinum and liver.

Score of 1 = no abnormal FDG-avidity
Score of 2 = uptake less than mediastinum
Score of 3 = uptake greater than the mediastinum, but lesser than the liver
Score of 4 = uptake greater than the liver
Score of 5 = uptake greater than the liver and with new sites of disease

Question 10

Which B cell lymphoma is a/w the highest percentage of patients with Ann Arbor Stage IV?

Answer 10

Small lymphocytic lymphoma/chronic lymphocytic leukemia is the one most commonly a/w stage IV at Dx (80%)

MCL (70%)

PTCL (60%)

Question 11

Which virus causes Castleman’s disease

Answer 11

HHV-8

Question 12

Which disease is a/w HHV-8?

Answer 12

Castleman’s disease

Question 13

What lymphoma is associated with Hep C?

Answer 13

Monocytoid B-cell lymphoma

Splenic MZL

Question 14

Which virus is monocytoid B-cell lymphoma a/w?

Answer 14

Hep C

Question 15

Which translocation is a/w MALT lymphoma?

Answer 15

T(11;18)q(21:q21)

- produces Antiapoptotic API2-MLT fusion protein, which is activated as a consequence of the fusion

Question 16

Translocation t(11;18)q(21;21) is a/w what lymphomas?

Answer 16

MALT lymphomas

Question 17

What lymphoma is isochrome 7q deletion a/w?

Answer 17

Hepatosplenic T-Cell lymphoma

Question 18

Which genetic aberration is a/w isochrome 7q deletion?

Answer 18

Hepatosplenic T Cell lymphoma

Question 19

In CLL/SLL, unmutated Ig V region is a/w aggressive disease. T/F?

Answer 19

True.

Correlates with ZAP-70 expression and CD38 expression

Question 20

What translocation is a/w lymphoplasmacytic lymphoma?

Answer 20

Translocation t(9;14)(p13;q32) and rearrangement of PAX-5 Gene

Question 21

Describe Lymphoplasmacytic Lymphomas

Answer 21

Neoplasm of small B lymphocytes, plasmacytoid lymphocytes and plasma cells

• lack CD5, CD10, CD23
• strong expression of sIg and CD20

CLL has: CD10-
CD5+, CD23+

Question 22

What is the most common TCR subtype observed in lymphomas?

Answer 22

Alpha-Beta subtype

TCR gamma-delta is seen hepatosplenic T_Cell lymphoma and some cases of enteropathy-type T-Cell Lymphoma

Question 23

What is he usual IHC stains for Follicular lymphoma?

Answer 23

CD10+
CD20+
CD5-
BCL2+ (mostly)
Some with nuclear bcl-6+

Question 24

Where are the common sites of CNS relapse?

Answer 24

Parenchymal brain lesions
Spinal cord
Leptomeningeal
Combinations

Question 25

What are the risk factors for CNS relapse in patients with aggressive B Cell Lymphoma?

Answer 25

1) Advanced Stage
2) Elevated LDH
3) B symptoms
4) Site - Testis, paranasal, orbit, Bone marrow, breast
5) Epidural lesions
6) young age

Question 26

Give me example of small B-cell lymphomas

Answer 26

Chronic Lymphocytic Leukemia (CLL)/ Small lymphocytic lymphoma (SLL)
MCL
FL
Marginal zone lymphoma

Question 27

Described T-cell lymphomas morphologically

Answer 27

Heterogeneous population of small, medium-sized, and large neoplastic T cells

Question 28

When does CD20 expressed ?

Answer 28

Appears later with the light chain rearrangement

Question 29

What is useful in the diagnostic work-up of T-cell lymphomas?

Answer 29

CD3, CD2, CD 5, CD7 recognize virtually all mature T cells

Question 30

What are their fertility preservation options?

Answer 30

Semen cryopreservation
IVF
Ovarian tissue cryopreservation
Ovarian locate cryopreservation
Oophoropexy