General Lymphoma Flashcards
What is the CD Marker for a stem cell?
CD34
What are the markers for Granulocyte, monocytes, T-lymphocyte, B-lymphocyte, thrombocytes?
Granulocyte = CD45/CD15 Monocytes = CD45/CD14
T-Lymphocyte = CD45/CD3 B-Lymphocyte = CD45/CD19
Thrombocytes = CD45/CD61
What are the CD markers for Helper T-Lymphocyte, Cytotoxic T-Lymphocyte and Activated T-Lymphocyte?
Helper T-Lymphocyte = CD45/CD3/CD4
Cytotoxic T-Lymphocyte = CD45/CD3/CD8
Activated T-Lymphocyte = CD45/CD3/CD25
What are the CD markers for B Lymphocyte?
CD45/CD19/CD20
CD24/CD22
CD38
What are the CD Markers for NK cell?
CD15
CD56
CD31, CD30, CD38
CD3-
How often is the bone marrow involved in lymphoma?
40% Low-grade
40% Intermediate-grade
20% High-grade lymphomas
How often does HBV Reactivation occur with cytotoxic chemotherapy ?
20-50% with HBsAg +
3-45% with HBcAb +
What lymphoma is Hep C associated with?
NHL, esp B Cell lymphomas
Tell me about the 5-point scale and PET-CT
The 5-PS is based on the visual assessment of FDG uptake in involved sites relative to the mediastinum and liver.
Score of 1 = no abnormal FDG-avidity
Score of 2 = uptake less than mediastinum
Score of 3 = uptake greater than the mediastinum, but lesser than the liver
Score of 4 = uptake greater than the liver
Score of 5 = uptake greater than the liver and with new sites of disease
Which B cell lymphoma is a/w the highest percentage of patients with Ann Arbor Stage IV?
Small lymphocytic lymphoma/chronic lymphocytic leukemia is the one most commonly a/w stage IV at Dx (80%)
MCL (70%)
PTCL (60%)
Which virus causes Castleman’s disease
HHV-8
Which disease is a/w HHV-8?
Castleman’s disease
What lymphoma is associated with Hep C?
Monocytoid B-cell lymphoma
Splenic MZL
Which virus is monocytoid B-cell lymphoma a/w?
Hep C
Which translocation is a/w MALT lymphoma?
T(11;18)q(21:q21)
- produces Antiapoptotic API2-MLT fusion protein, which is activated as a consequence of the fusion
Translocation t(11;18)q(21;21) is a/w what lymphomas?
MALT lymphomas
What lymphoma is isochrome 7q deletion a/w?
Hepatosplenic T-Cell lymphoma
Which genetic aberration is a/w isochrome 7q deletion?
Hepatosplenic T Cell lymphoma
In CLL/SLL, unmutated Ig V region is a/w aggressive disease. T/F?
True.
Correlates with ZAP-70 expression and CD38 expression
What translocation is a/w lymphoplasmacytic lymphoma?
Translocation t(9;14)(p13;q32) and rearrangement of PAX-5 Gene
Describe Lymphoplasmacytic Lymphomas
Neoplasm of small B lymphocytes, plasmacytoid lymphocytes and plasma cells
- lack CD5, CD10, CD23
- strong expression of sIg and CD20
CLL has: CD10-
CD5+, CD23+
What is the most common TCR subtype observed in lymphomas?
Alpha-Beta subtype
TCR gamma-delta is seen hepatosplenic T_Cell lymphoma and some cases of enteropathy-type T-Cell Lymphoma
What is he usual IHC stains for Follicular lymphoma?
CD10+ CD20+ CD5- BCL2+ (mostly) Some with nuclear bcl-6+
Where are the common sites of CNS relapse?
Parenchymal brain lesions
Spinal cord
Leptomeningeal
Combinations
What are the risk factors for CNS relapse in patients with aggressive B Cell Lymphoma?
1) Advanced Stage
2) Elevated LDH
3) B symptoms
4) Site - Testis, paranasal, orbit, Bone marrow, breast
5) Epidural lesions
6) young age
Give me example of small B-cell lymphomas
Chronic Lymphocytic Leukemia (CLL)/ Small lymphocytic lymphoma (SLL)
MCL
FL
Marginal zone lymphoma
Described T-cell lymphomas morphologically
Heterogeneous population of small, medium-sized, and large neoplastic T cells
When does CD20 expressed ?
Appears later with the light chain rearrangement
What is useful in the diagnostic work-up of T-cell lymphomas?
CD3, CD2, CD 5, CD7 recognize virtually all mature T cells
What are their fertility preservation options?
Semen cryopreservation IVF Ovarian tissue cryopreservation Ovarian locate cryopreservation Oophoropexy
