General Internal Medicine Flashcards
overall prevalence of PAD in pt iwth Age 5-69 with DM.tob/age>70
29%
Pt with PAD risk factors and suspect PAD wtd?
Ankle brachial index
N- >1
1.3=arterosclerosis
68yo M p.w intermittent claudication of legs - quit smoking 10ya - BP left arm 128/84, BPR R arm 134/82 BP RLE 128.80 - ABI =
128/138=0.92
(choose higher UE SBP) LE/UE SBP
If equivocal ABI (0.9->1)
Excercise ABI
How to manage PVD
modify risk factors (BP, gluc, chol)
Anti plt agens ASA+- palvix
Treat claudication - supervised exc program>cilostazol>pentoxyifylline
Whatd medicatio nused in PAD reduced coronary events regardly of BP effect
ACEi
T/F - Pt with PAD aggressive control of hyperlipiddemia with statin drug a/w reduced overall mortality
T
T/F - Pt with PAD aggressive control of hyperlipiddemia with statin drug a/w reduced vascular mortaility
T
T/F - Pt with PAD aggressive control of hyperlipiddemia with statin drug a/w reduced cornoary events
T
DM goals
LDL<140/80 with PAD
Pt with sudden onlset pain in foot, discoloration of oot h/o afib - petal and poterior tibila pulses not felt wtd?
arteriogram r/o embolic event from afib
Pt wit sudden onset black/blue toes, pulses felt, had cardiac cath earlier and BP elevated wtd?
Adequate BP control
Metabolic syndrome
Obestiy waist in males 40" (>35 asian) 35" in femael (31" asian) TGA Low HDL 140.85 FBS >100 Tx: Diet, exercise, drugs
Which antilipid medication woudl tx component of metabolic syndrome
Fibrate
Obesity leading cause of death in US
BMI Normal 19-25 overweight >25 Obeste stage I >30 stage II >35 Morbid obesity >40
Complications of obesity
Type II DM Ca endometrial>breast>postate>colon ele LDL, TGA dec HDL inc'd CAD risk, SCD OA NASH OSA FSG (NOT OSTEOPOROSIS - protective)
45yo F gaining wight - BMI 31 FBS 105 wtd?
reduce caloric intake 500 to 1000 cal/day
Pt BMI 32 on red caloric intake 3 months later with BMI 31 - what med for long term use
Orlistat
Lorcaserin
Phentermine topirate
Indications for bariatric surgery
BMI>35 with DM/hyperchol or HTN or CHF or OSA
BMI>40 with no other conditions
Bariatric surgery reduces mortality?
T
Post gastric bypass surgery - next day with horizontal nystagmus and opthalmoplegia dx?
Thiamine deficiency
Post bariatric surgeryc/o wk and dark colored urine, tenderness of back muscles - U dip stick + blood no RBCs dx?
Rhabdomyolysis
Post bariatric srugery 3 days later with tachcardia nad tachypnea
PE
Post gastic bypass 2 days later with RR 22, HR 120, tmep 100.8 dx?
Anastomatic suture /stable leak - gastrograffin study needed
Long term deficit post bariatric surgery
Vit D, B12, copper, iron
38yo F BMI 40 bariatric surgery 5ya fo rphysical - Hg 10.5, MCV 105 plt 115, retic 1%
check B12/cyanocobalamin
34yo F roux en y surgery 8 monts ago - BMI dropped 40 to 28 - now BMI up to 35 - c/o heartburn
dx? Gastrogastic fistula
35yo F post bariatric surgery BMI 40-25 in 6 montsh - no ids - nauseous and bloating wtd?
preg test
Waist to hip ratio >0.9 in men >0.85 W risk factor
at any rate
Inc’d waist to hip ratio considered CAD risk factor in what grop of patients -
older age
Exc a/w
protection against CAD dec'd LD, TGA inc HDL improved gluc tol reduction of weight, BP, stress red'd mortality from all causes
Pt s/p IWMI d/c’d with AS B blocker, ACEi and statin - what else would dec mortalty
exc 1hr day, 5 days / week (not just 3 days 1/2 hr)
Pt p/w fahes or streak of light shows, black dots, wavy curtain - cobwe always movee whereever pt looks - initally with normla visual acuity - fundoscopy with retina appearing folded/elevated wtd?
retinal detachment - Urgent opthal eval for laser tx
Pt with afib sudden onlset painless vision loss in one eye - fundscopy CHERRY RED SPOT IN MACULA etio?
retinal artery occlusion
60yo with waldenstrom’s macroglobulinemia, HTN or P vera with sudden painless los of vision one eye - fundopscopy with multiple hmorrhages - thunder & clouds dx?
retinal vein occlusion
Elderly man with blurry vision in CENTER, peripheral vision spares - fundscopy with yellow spots (druzen dx?
Macular degeneration - tx
tx: quit smoking anti oxidant vitamins
Pt going for cataract surgery taking ASA or warfarin or plavix wtd?
continue ASA/warfarin
d/c tamsulosin (avoid floppy iris syndrome)
Young woman with blurry vision esp after excercise - regains vision gradually - wtd?
T2 MRI r/o Multiple sclerosis
Optic nerve infarction
temporal arteritis
tx: steroids
Pt with long standing DM, mild vision, fundscopy -> aneurysms with hemorrhage and exudates
non-prolif retinopathy (backgroudn) with macular edema
TIGHTER glucose control
Pt with long standing DM with blurry vision Fundscopy->neovascularization
dx: prolif DM retinopathy
tx; lasery therapy - periphera nd night vision decreased but central vision spared
Pt with HgA1c of 7% has laser tx for DM retinopathy no response - wtd?
Tighter glucose control
Pt with r eye pain, facial pain, n/v/ h/a blurry vision - R pupil dilated, sluggislhy reactive - ciliary flush hazy cornea with congestion
Glaucoma
25yo F dec’d vision in L eye with pain - paraesthesia in feet
Optic neuritis
Elderly man with progessive loss of central vision - edge of door hazy
macular degeneration
Sudden loss of vision in one eye, fundoscopy Cherry red spot
retinal artery occlusion
Sudden oloss of vision in one eye fundoscopy multiple hemorrhages and exudates
retinal vein occlusion
New monset shower of floaters with flashes of light and cobweb
retinal detachment
Magnifying glass
macular degeneration (also anti-oxidant vit’s and quit smoking)
Crystals in retinal artery (Hollenhorst plauques)
Cholesterol emboli
Pt with intermittent visual loss - fundscopy with crystals in retinal artery wtd?
Carotid duplex US
test to establish infective endocarditis
Blood ctx
60yo pt wit difficulty driving at night from glare from oncoming cars - diff reading road signs and fine print - dx?
Cataract
Pt with cataract surgery one week ago with eye ache and decreasing vision - otherwise well - afebrile - injected conjunctivea - layer of WBC in anterior chamber slit lamp with intraocular WBC - COTTON WOOL SPOTS - dx?
endopthalmitis
Conjunctivitis
Viral - adneovirus
Bacterial
Allergic
Tx - cool compression or abx or anti-histamines
Pt pw conjunctivitis with serous d/c - prescripbed abx eye drops - 4th day is worse - dx?
allergy to drops
tx: d/c drops
Red eye with itchiness
allergic conjunctivitis
Pt with red eye with graves or RA with dry eyes and gritty sensation
Keratoconjunctivitis sicca
tx: artificial tears
Red eye with pain and photophobia, constricted irregular pupil - ciliary flush normal cornea and normal intraocular pressure - slit lamp - WBC in aquous humor or on corneal epithelium - consensual eye reflex with pain dx?
Iridocylitis (Anterior uveitis) Emergent referal to opthalmologist intensive topical steroid to reduce inflammation cycloplegics to prevent synechiae tx underlying dz
Pt with red eyes and foreign body sensation with pain - corneal exam with DENDRITIC ULCER - branchign - fluorescin stain +
HSV I keratitis
Tx: topical triflurodine (no acyclovir)
Pt intubated on mechanic vent wit one eye redness - cornea white
Pseduomonas keratitis
Tx: topical antipseduomonal
IV anti-pseudomonals
Pt with contact lense develops conjunctivitis
Pseudomonas keratitis
Glaucoma
inc’d intraocular pressure- progressive visual loss 2/2 optic nerve damage
Complication - gradual loss of peripheral vision
Open ange glaucoma
gradual loss of peripheral vision
Cup to dis ratio >50%
Inc’d incidence in AA’s
45yo F pw/ R eye pain and temporal headache - exam with conjunctival inection in R eye and vision 20/200 - pupil mid-dilated, fixed, non-reacitve wtD?
urgent referral to opthalmologist - before tx - give PIOLCARPINE drops
22yo p/w ER with teary eyes - hit in eye with paintball - exam with mid conjunctival injection pupillary refelx normla vision normal Slit exam with linear abnormality wtd?
No therapy f/u PRN
Pt p/w teary eye - pupillary refle normal wood lamp after fluorescin patttern of parallel lines of vertical abrasion - vision normal wtd?
every eyelid and remove foreign body
High velocity and insdustrial injury with hyphema (blood in anterior chamber
urgent referral to ophthalmologist
Pt witih conjunctiviti - exam layers of WBC in anterior chamber
refer to ophthalmoligst
Hypopyon - lyering of white cells in anterior chamber
Coudl be ophthalmitis or keratitis - urgent referral needed
Pt with cough - exam with redness in conjunctiva - wtd?
nothing - subconjunctival hemorrhage resolves spontaneously in 1-2 weeks
Pt with diplopia of a few days duration with h/a - on exam lookign stright left is inward and right eye is also slightly inward - dx of b/l lateral rectus palsy made - dx?
cavernous sinus thrombosis
Cellulits of periorbital area with warth swelling around eye wtd?
CT/MRI - orbital cellulitis-> cavernous sinus thrombosis
tx: IV anti-biotics
Pustule on lid margin
Stye
tx: warm compess - may need surgery
Vascular structure in conjunctiva - can spread to cornea and impair vision
dx: pterygum
Tx: surgery
Inflammed eyelid
blephritis
small nodule under tarsus
Chalazion
etio obstruction of meibomian gland -
Tx: warm compress - surgery may be needed
AIDS pt with blurry vision - fundsocpy with cheese, ketchup appearance
Dx: CMV retinitis
tx: gancyclovir
How to manage otitis media
Amoxicillin
Pt with recurrent chronic ear infection p/w d/c and MASS out of tympanic membrane - hearing loss on that side - dx?
Cholesteatoma
Pt with c/o hearin gloss - esp in crowded area - wtd?
2 feet whisper test
If 2 feet whisper test abn - tuning fork at mastoid with no response - tunign for at forehead no response dx?
b/l presbycusosis
30yo F with gradual hearing loss - whisper test abn, can hear better with tuning fork at mastoid process than near ear - keeping tunign for at forehead with better hearing in both ears - dx?
b/l otosclerosis
(abn growth of bone in middle ear - conductive hearing loss)
fixation of stapes bone
Tx - surgery
Pt with hearing loss in R ear - webber’s test localizes to R ear - exam with obstruction of typanic membrane by cerumen wtd?
Webber test - tuning fork on forhead
Normal = hearing same both ears
If defective ear hears sound louder - CONDUCTIVE hearing loss
If normal ear hears sound better than SENSONEURAL hearing loss
RHINE test - first tuning for on mastoid bone - when can’t hear that tuning for in front of canal - normal(or sensoneural) if Air conduction (AC) louder than bone conduction (BC)
If BC>AC then conductive hearing loss
Pt pw c/o discarhge from R ear - exam with pain on pulling ear up and out - d/c and debri in ext auditory canal and partial obsstruction of typmapinc membrane dx?
Swimmer’s ear
Tx: poymyxin drops
Pt with otitis externa in DM - red ear
malignant otitis externa
cover with 2 anti-pseddoonal abx - ceftazidime and amikacin/tobramycin
Pt going for surgery - pt has LBBB and asx wtd?
clear for surgery
Pt with severe PVDz going for vasc surgery or aneursym repair - wtd prior to OR
thallium or dob stress
Pt for elective surgery - multiple PVCs asx no evidence of ischemia
Clear for surgery
70 HTN OA going fo rhip replacement
Clear for surgery
Pt with colon CA going for colon surgery father MI 49 wtd?
Clear for surgery
Pt with CABG 7ya with occasion CP on exertion schedule for urgent AAA 7.5cm in AM - abd tenderness and pulsatile mass wtd?
Emergency surgery - high risk - clear fo rsurgery
After MI when should elective surgeries be done?
6 months
Pt with stable angina going for surgery wtd?
c/w angina meds pre and post surgery
Pt post op after CABG in CCU with confusion, disoriented, doesn’t follow commands inattentive pulling ET tube HR 100 wtd?
haldol
What med can cause delirium in elderly during post op period?
Meperidine (demerol)
Pt in recovery room and BP 160/104 not known HTN
morphine sulfate for adequate analgesia (pain causing htn)
Pt with severe abd pain - xray with air under diaphragm - c/s for learance - while doing consult pt vomints and becomees bradycardic - EKG HR 48, some non-conducted p-waves and 1mm ST dep
Inc’d vagal tone from vomiting - clear for surgery
What has been shown to decrease risk of perioperative complications?
Lugn exapansion interventios (incentive spirometry, deep breathing, CPAP)
What is recognied as risk factor post non cardiac surgery
inc’d tropoinin T levels < 72hrs after surgery
40yo F s/w PNA - next mornign see’s “little green ppl
Or 40yo M a/w GIB see’s “spiders on ceiling” exam afebrile HR 84 bp OK - Mild tremulousness - fhx etoh abuse - thiamine give dx?
etoh hallucinations
DT with inc HR/BP
Pt had urgent surgery yesterday today oriented x 2, temp 101, HR 105 mild tremor dx?
etoh withdrawal
Pt with anxiet, tremors confusion HR 104, BP 150/92 deslusional and seizure
Delirum tremons -
Tx Diazepam, lreazepam phenobarb - propofol
54yo chornic alcoholic to ER with confusion ataxia nystagmus diplopia
Wernickes encephalopathy
Tx FIRST thiamine then glucose
Chornic alcoholic with anterograde and partial retrograde amneis - confabulatory speech
Korsakoff psychosis - poor prognosis
Pt with SOB, tach and bounding pulse - CXR cadriomegaly
thiamine def - high output cardiac failure (beri beri)
Pt with h/o etoh in hosptial - gets thiamine, glucose and is fed wel - 5 days later uscular weaknes - sob - CPK inc’d Hg dec reti ct inc’d
Refeeding syndrome - hypophosphatemia
Chornic etoh wit muscle sapsms - serum ca low, K low wtd?
FIRST give magnesium then K/Ca+
Pt underoes surgery - post op seizure tachy, consfused tachypnic
etoh withdrawal
Lifetiem incidence etoh abuse and drug abuse
20%
etoh abuse screening
Cage, AUDIT, 4 drinks on one occsion in men (3 in F)
C - cutting donw
A - annoyed
G - guilty
E eye opener?
Addressing etoh - SBIRT - screeing brief intervetion referral fo rtx
Etoh abuse
Problems - failures to fulfil work/school oblig, use in hazardous situation, legal proglems with etoh use - constineud use despote social problems
etoh dependence
keeps drinking - work/social school oblsigations sacrified - tolerance - needs more and more
desire to cut down but continues
withdrawal sx if stops
Pt p/w routine checkup - depressed - inc’d MCV, inc’d GGT - what wil establish chronic eetoh abuse
inc’d carboydrate free transferrin
Etoh abuser on sidewalk to ER pain in legs no back pain exam wk fo foot and dec’d ankle jerk - dx?
etoh neuropathy
MCC death etoh abusers
heart disease
All true about alcoholism
inc’d malignancy incidence
inc’d MVA
inc’d suicides and drug OD
inc’d STDs
Best drug to tx etoh addiction in addition to support goups?
Naltrexone
Pt with normal FBS - white/gray spots on conjunctiva dx?
Vit A deficiency
Pt taking multiple vitamins p/w dizziness, hza, abd pain n/v elev LFTs Ca 10.7, xerosis of skin dx?
Vit A toxicity
Pt with nausea labs Ca 11, fundsocpy blurring of disk margin - pt takes multiple vitamins dx?
Vit A toxcity
Pt lives on tea and toast diet pw bleeding gums - perifollicular hemorrhage and non-healing ulcer - coages, plts’ normal dx?
Vit C deficiency - scurvy
PP+ pt on INH pw pin pricks and tingling on legs - low MCV
Vit B6 def - inc’d homocystine
Pt taking multiple vitamins with HEADACHES - fundoscopy papilledema
Pseduotumor cerebri
etio? Vit A intoxication
50yo chronic etoh with sensory ataxia with romberg +, deemntia dec’d proprioception, spasticity optic neuropathy but normal pin pricke
Dx: subacute degen of cord 2/2 vit B12 def
elev MMA
Pt takes multiple vitamins p/w nausea, anorexia fatigue sever constip - MM dry Ca 11.3, pho 5.2 dx?
Vit D intoxication
Pt with dementia diarrhea dermatitis
Pellagra (niacin) deficiency
Diarrhea and LINEAR VERTICAL LINES on nails
Arsenic posoning
Pt wit hlong ICU stay on TPN with ALOPIECIA, hyeprkeratotoic rash, anemia, LOSS OF TASTE
Zinc deficincy
Post surgery NPO on IVF with inc’d PT etio?
Factor VII def
Pt post surgery in ICU with nausea is given phenothiazine - next day horizontal nystagmus ophthalmoplegia dx?
Wernicke’s encephalopathy
Cheilosis, glossitis, dermatitis
Vitamin B2 def (riboflavin)
Iodine
goiter or hypothyroid
Bleeding diathesis
Vit K def
Cardiomyopathy, CHF
Selenium
hypophophatemia
Thiamine
Anxiety d/o
Panic d/o GADisorder Phobias Obsessive compulsive disorder Post Traumatic disorder
Discrete period of intnese fear and anxiety, womatic sx SOB palpitations, trembiling diaphoresis ches tpain discormfort - click+MVP
Panic d/o
Percieved difficult to escape situation
Agoraphobia
TCA/SSR
benzo - short term
Excessive anxiety ou tof proportion of fear to impact of fear event
Gen anxiety d/o
Tx: buspirone
cognitive behav therapy
40yo F with complaints of CP, palptiatons diaphoresis and numbness while watching movie/concer - happened couple times before EKG normal wtd?
start benzos and re-eval in 2 weeks
tx: SSRI
Pt with feeling of vibration sense inside body - has CP, palptiations, SOB - exam mid systolic click - dx?
Panic attack
Tx: Paroxetine
Persistent distressing thought -> obsession
Repetive response to the persistent thought -> compulsion
Dx. Obesessive Compulsive disorder
Tx: Fluoxetine, Fluvoxamine, Clomipramine (TCA), behavior modification
Fear of public speaking with sweating and trembling
Phoic situation
tx: B Blocker
TCA
Vietname vet - saw friends die - pw nightmares, avoidance of remnder of even, flashbacks intrusive memories
Dx: PTSD
tx: Psychotx, SSRI
Young woman witih multiple complaints multiple organ systems >8 - exam NO macthcing physical findings to sx
Dx: Somatization d/o
tx: - PCP, psychiatrist - monthly appt with PCP for reassurance and dec of utilz of health care resources
Pt with alteration or loss of physical fxn wihtout pathologic basis - pt is unawar - not concoiously producing sx -
dx: conversion d/o
Tx: usually responds to suggestive therapeutic modality
Young woman of high socioeconomic status related to health care field with h/o emtional trauma p/w deliberate production of signs and sx
dx: Factitious d/o
A man of low socioeconomic status with deliberte production of signs and symptoms pathologic lying and wandering
Munchausen’s
Intentional prodxn of signs and sx for SECONDARY gains. Such as avoiding military duty or court case etc
malingering
Physical findings dont’ match multiple complaints
Somatization
Doctor shopping and high utilization of health care
Somatization
Needs PCP q1month appts
Somatization
Weakness one side of body but w/u normal with MRI
Conversion d/o
Young white femail nurse deliberate prodxn of sign’s and sx
Facticious d/o
Factious d/o with pathologic lying and wandering
Muchausen
Exaggerated sx compared to physical exam - pending court case or military service
Malingering
Depression
depressed mood
loss of interest in pleasurable activities
wt loss/gain
Insomnia or hypersomnia
Fatigue
Diminshed ability to concentrate
Sx >2 weeks=depression
If sx after death in family and sx < 2 months - bereavement
> 2 years - dysthymic
If abv sx with delusions/hallucinations - depression with psychotic features
Depression
MCC suidcide
Tx with any antidepressant - 4-9mo
HOw soon see response - 2-6 weeks
When to switch if no response - 6-8wks
Recurrent > 2 episodes of depression - 2 or more years
When stopping drug - taper it
Psychotx - Cognifitive tx - Thought->emtion-behavior
Interpersonal tx
Don’t go from SSRI-> bupriopion (ok other way around)
Mcc suicide in US
major depression
Depression
anti antidperessant
Enuresis
Imipramine (TCA)
Panic d/o
Alprazolam SSRI
Obsessive-compulsive d/o
Fluoxetine
Clomipramine
Fluvoxamine
Chronic pain+- depression
Amitriptyline
Smoking cessation
nicotine replacement->bupropion->vareniciline
Insompnia
Amitrptyline, trazadone
Overdowse with low lethal potentila
citalopram (SSRI)
45yo M pw depression - stated on fluoxetine and starts to feel better in 3 weeks how long to continue
4-9 months
83yo F awake, doesn’t respond to stimuli x few months - refelxes/power intact dx?
depression
Terminally ill pt with lung CA depressed, loss of appetite - loss of interest in life wtd?
Methyphenidate - elevates mood w/in days and can be used with other anti-depressants which take weeks
Drug-drug interactions
MAOI
HTN crisis
MAOI (Phenelizine, selegilen)
Orhostatic hypotension
TCA (imipramine, clomipramine, amitrypyline, nortriptyline)
Antichol s/e (dil pupil, tachy, dry secrtions)
TCA
sexual dysfxn
SSRI (fluoxetine, citalopram, sertraline
Least sexual dysfxn
Bupropion
Avoid in anemia
SSRI/Buproprion