General Immunosuppressants

Question 1

Target: CD3 Receptor

Answer 1

Component of TCR; will prevent T cell activation

Question 2

Target: CD-28–B7

Answer 2

Produces critical co-stimulatory signal; will prevent T cell from becoming fully activated

Question 3

Target: Calcineurin

Answer 3

Phosphatase responsible for controlling nuclear access of transcriptional factor NFAT; Will cause T cell to fail to up regulate IL-2

Question 4

Target: Nucleus by Glucocorticoids

Answer 4

Inhibits transcriptional regulation of pro-inflammatory genes; will diminish release of IL-2