Anti-inflammatories Flashcards
Vasodilation mediators that can be affected by drugs:
PGs, I2, E1, E2, D2
Increased Vascular Permeability mediators that can be affected by drugs:
Histamine, LTs, C4, D4, E4, and CGRP
Fever mediators that can be affected by drugs:
IL-1, IL-6, TNF, PGE2, PGI2, LTB4, LXA4, LXB4
Pain mediators that can be affected by drugs:
PGE2, PGI2, LTB4, CGRP
- What causes initial bronchospasm and release of inflammatory mediators in asthma?
Histamine
How do antihistamines work?
They block effects of histamine binding to H1 receptors, but do not block them from their release from mast cells
What inflammatory mediators are released by histamine?
PGs, LTs, Platelet Activating Factor (PAF), Eosinophil Cationic Protein (ECP), Major Basic Protein (MBP), and proteases
What type of drug has this mechanism:
Transcriptional regulation inhibitor
Corticosteroids
What type of drug has this mechanism:
Synthesis inhibitors
NSAIDs, Zileuton
What type of drug has this mechanism:
Soluble Cytokine Receptor
Certolizumab, Adalimumab
What type of drug has this mechanism:
Blocking monoclonal antibody
Certolizumab, Adalimumab
What type of drug has this mechanism:
Receptor blockers
Antihistamines, Montelukast
What drug is a(n) inhaled corticosteroid
Beclomethasone
What drug is a(n) oral corticosteroid
Prednisone
What drug is a(n) Leukotriene Receptor Blocker
Montelukast
What drug is a(n) Leukotriene Synthesis Blocker
ZIleuton
What drug is a(n) IgE-Antibody
Omalizumab
What drug is a(n) PDE4 Inhibitor
Roflumilast
What is an NSAID derived from salicylic acid?
Acetylsalicyclic Acid (Aspirin)
What is an NSAID derived from Non-Selective COX inhibitor?
Ibuprofen, Indomethacin, Naproxen
What is an NSAIDthat is a COX-2 specific inhibitor?
Celecoxib
What is an analgesic, antipyretic NSAID?
Acetaminophen
What drug is an anti-IgE antibody and what is its MOA?
Omalizumab, reduces likelihood of histamine release. The mast cells release histamine but the antibody does not receive the signal.
What are the 1st generation antihistamines?
Diphenhydramine, Chlorpheniramine, Dimenhydrinate, and Promethazine (can access the BBB)
What are the 2nd generation antihistamines?
Cetirizine, Fexofenadine, Loratadine
What drug treats COPD and what is its MOA?
Roflumilast, selectively inhibits PDE4
What are the TNF-alpha inhibitor drugs?
Etancercept, Infliximab, Adalimumab, Certolizumab Pegol
Which of the TNF-alpha drugs is not a monoclonal antibody?
Etancercept
