General Embryology Flashcards
what are the three periods of general embryology?
preimplantation
embryonic
fetal
fertilization causes the formation of what?
zygote
mitosis of the zygote leads to formation of what?
blastocyst
growth factors, and cell adhesion molecules act through what?
signaling complexes which activate various transcription factors, affecting cellular changes
what are some changes that may occur due to growth factor or cell adhesion molecules
proliferation, differentiation or apoptosis
what are the ways growth factors can act?
autocrine, paracrine, or endocrine
*mostly through paracrine
why is Bone Morphogenic Protein (BMP) important in craniofacial development?
induction, formation, determination and migration of neural crest cells
- patterning and formation of facial primordia
- negative regulator of myogenesis
- regulator of early tooth morphogenesis and differentiation
- *at gastrulation, it switches between epidermal vs. neural fate
Homeobox genes code for what?
transcription factors that begin to make cells pattern into one tissue/organ type or another
*involved in segmentation
HOX genes
function in pattering the body axis(rostral caudal) and determine where limbs and other body segments will grow in developing fetus
Msx genes
control cellular process of differentiation and proliferation during development
Dlx genes
control development of ectodermal tissues derived from lateral border of neural plate
-distal proximal of pharyngeal arches
Shh (sonic hedgehog) genes
play important role in early induction of facial primordium
cell adhesion molecules are responsible for what?
specific cell aggregation and sorting
calcium dependent=cadherins
calcium independent=CAM
after initial cleavage of the zygote the solid ball of cells is known as what?
morula and then later becomes a blastocyst
by the end of the first week the blastocyst stops traveling and does what?
implants into the thickened uterine wall in a processes called implantation
what are the components of a blastocyst
outer most cells are trophoblast, inner ball of cells is the embryoblast, and then the yolk sack fills the rest of the space
the embryonic period begins and ends when?
starts at the end of the second week
ends at the end of week eight
what occurs during the embryonic period
spacial and temporal events called pattering
what are some of the pattering structures that will form during the embryonic period?
pharyngeal arches, somtie development, face development, palate and tongue
embryonic phase: patterning
- axial specification
- segmentation
- tissue and organ specialization and formation
- dentition development regionally