General Anesthetic Pharmacology Flashcards
what drug class is used as an IV inductive agent?
benzodiazepines
what are the 4 components of anesthesia?
- pain relief
- immobility
- amnesia
- loss of consciousness
true or false: ketamine has intense analgesic effects
true
what does ketamine cause dissociation of?
dissociation of thalamus to limbic cortex
true or false: ketamine can depress a newborn
false
what do the barbiturates produce?
amnesia
what are 4 characteristics of analgesia?
- loss of response
- amnesia
- analgesia
- unconsciousness
what are the 5 pros to the use of ketamine?
- analgesic effects
- does not depress CV
- does not depress RS
- fast onset
- decreases central sensitization
what are the 5 cons to the use of ketamine?
- emergence delirium
- can increase CBF & ICP
- increase muscle tone
- hallucinations
- increase secretions
what can propofol cause upon injection?
pain
true or false: propofol has an increased clearance rate leading to less of a hangover effect
true
what is the duration of action of propofol?
2 to 8 minutes
what are 5 pros of propofol?
- not effected by CRI
- depresses airway reflexes
- less hangover effect
- increase onset & metabolism
- antiemetic effects
what are 5 cons to the use of propofol?
- myocardial depressant
- hypotension
- respiratory depression
- inadequate analgesia
- metabolic acidosis
if someone has an allergy to eggs can they use propofol?
maybe
what is the structure of thiopental?
barbituric acid derivative
what is the MOA of thiopental?
suppresses excitatory transmission
what are the 5 pros of thiopental?
- less expensive
- decrease cerebral metabolic rate
- decrease cerebral O2 consumption
- decrease cerebral blood flow
- limits seizure activity
what are 5 cons of thiopental?
- bronchospasm
- respiratory depressant
- myocardial depressant
- hangover effect
- anti-analgesic effect
what is the MOA of etomidate?
suppresses excitatory transmission
what ar e4 pros of etomidate?
- myoclonus activity
- decreased adrenocortical
- increases in N/V
- no analgesia
what mechanism accounts for the initial termination of the effects of intravenous anesthetics?
redistribution
what are the 2 main ADRs of precedex?
hypotension and bradycardia
what doesn’t ideal anesthetic gas trigger?
malignant hyperthermia
