General Anaethetics

Question 1

Etomidate

Answer 1

IV administration
Metabolised faster than thiopental
Induction of anaesthesia
Targets GABA a receptor (B2 or 3 subunit) - prolongs IPSP
Action blocked by N265M mutation - transmembrane domain of B2

Question 2

Propofol

Answer 2

IV administration
Faster metabolism than thiopental
Used for induction and sometimes maintenance of anaesthesia
Targets GABA a receptor - prolongs IPSP

Question 3

Halothane

Answer 3

Volatile inhalation
Targets a2b2y2 GABA receptor
Action inhibited by S270W mutation in a subunit
Potentials glycine receptor and TASK3 2P K+ current - inhibited by M159A mutation

Question 4

Isoflurane

Answer 4

Volatile inhalation
Targets A2B2Y2 GABA receptor - action inhibited by S270W mutation
Potentiates current at TASK3 2PK+ channel - M159A mutation

Question 5

Sevoflurane

Answer 5

Volatile inhilation

Question 6

Nitrous oxide

Answer 6

Inorganic gas

Fast rate of induction and recovery (low blood:gas coificient?)

Question 7

Xenon

Answer 7

Inorganic gas

Question 8

Alphaxalone

Answer 8

IV administration
Targets GABA a receptor - prolongs IPSPS
Not effected by N265M mutation

Question 9

Thiopental

Answer 9

IV Administration
Barbiturate
High lipid solubility
Unconsciousness within 20seconds lasting 10-15mins
Rapid redistribution but prolonged elimination - recovery result of redistribution
Eliminated via metabolism
Used for induction