General Flashcards
What is osteomalacia
Inadequate mineralisation of osteoid framework
Osteomalacia Clinical presentation
Proximal muscle weakness and pain
Low bone density
In children: bowed legs and knock knees (Rickets in children)
Pathophysiology of osteomalacia
Normal bone mineralisation depends on adequate calcium and phosphate.
Vitamin D promotes calcium absorption in intestines, promotes bone resorption (by increasing osteoclast number)
Aetiology of osteomalacia
Profound vit D deficiency
Lack of exposure to sunlight and/or GI malabsorption
Osteomalacia epidemiology
More common in pigmented skin and elderly
Treatment of osteomalacia
Oral calciferol
Diagnostic test of osteomalacia
X-ray (defective mineralisation)
When is an illness due to work?
Symptoms improve away from work or on holiday e.g. occupational asthma
Characteristic distribution of rash eg contact dermatitis
Sensorineural deafness with characteristic pattern on audiogram caused by noise
A cluster of cases in a workplace
Exposure to hazard can be linked to disease and exposure would not have occurred away from work
An injury is said to due to work when it has been caused by work, or work has substantially contributed to the injury
What are the epidemiological principles of causality
Bradford Hill criteria: Strength of association (high and significant odds ratios) Consistency in association Exposure-response relationship Specificity Temporal relationship Coherence of evidence Biologically plausible
Risk factors in work place for MSK problems
Heavy manual handling (>20Kg) Lifting above shoulder height Lifting from below knee height Incorrect manual handling technique Forceful movements Fast repetitive work; poor postures; poor grip
True or false:
Employers have a legal duty to avoid hazardous manual handling; undertake a risk assessment; reduce the risk of injury to as low as is reasonably practicable
Very True
Examples of MSK conditions of upper limb resulting from work
Carpal Tunnel Syndrome Hand-arm vibration syndrome (HAVS) Tenosynovitis Epicondylitis Repetitive strain disorder Rotator cuff problems Thoracic Outlet syndrome
Examples of MSK conditions of lower limb resulting from work
*Osteoarthritis of hip and/or knee
Plantar fasciitis, Housemaid’s knee
Tests of Carpal Tunnel Syndrome
Tinel’s and Phalen’s provoking tests
Aetiology of Carpal Tunnel Syndrome
May be caused by forceful and repetitive work
Extremes of flexion-extension of wrist eg painters, meat processors – Prescribed Disease IIDB (A12)
Hand-transmitted vibration (ORs 3-14) – Prescribed Disease IIDB (A12)
Associated with obesity, short stature, pregnancy, OCP, diabetes, hypothyroidism, RA, acromegaly
What nerve is compressed in carpal tunnel syndrome
Median nerve
Cause of Hand-arm vibration syndrome
Excessive exposure to hand-transmitted vibration (>2.5m/s2 per 8 hour day)
Chain saws, angle grinders, jack hammers, drills
Exclude other causes of neuropathy in hands