Gen Surgery Flashcards
Normal blood pH
7.35 to 7.45
Normal pCO2
35-45 is normal
↑ CO2 and ↓pH = respiratory acidosis
↓ CO2 and ↑ pH = respiratory alkalosis
If you don’t see a change in the CO2 in relation to the pH then take a look at the HCO3
Normal HCO3
20-26
↓ HCO3 and ↓pH = metabolic acidosis
↑ HCO3 and ↑ pH =metabolic alkalosis
Respiratory Acidosis
- pH <7.30
- high pCO2 60
- Normal Bicarb 22
Lungs fail to excrete CO2: Breathing too slow, pulmonary disease, neuromuscular disease, drug-induced hypoventilation due to opiates or barbiturates
Respiratory alkalosis
- pH >7.52
- low PCO2 25
- Normal Bicarb 22
Excessive elimination of CO2: Breathing too fast, pulmonary embolism, fever, hyperthyroid, anxiety, salicylate intoxication, septicemia
Metabolic Acidosis
- pH <7.30
- Normal pCO2 40
- Low Bicarb 16
- Calculate anion gap to tighten ddx: Anion Gap = Na – (Cl + HCO3-)
- Normal anion gap is 10-16
Metabolic Acidosis
- Increased anion gap
> 16
- Addition of hydrogen ions: Lactic acidosis (think metformin), diabetic ketoacidosis, aspirin overdose
MUDPILES:
- Methanol
- Uremia
- Diabetic Ketoacidosis
- Paraldehyde
- Infection
- Lactic Acidosis
- Ethylene Glycol
- Salicylates
Metabolic Acidosis
- Decreased anion gap
<16
Loss of bicarbonate: think diarrhea, pancreatic or biliary drainage, renal tubular acidosis
Metabolic alkalosis
- pH >7.52
- Normal PCO2 40
- High Bicarb
- Loss of hydrogen: vomiting, bulimia, overdose of antacids, addition of bicarbonate (hyperalimentation therapy)
6 predictors of surgical cardiac complications
- Ischemic heart disease
- Congestive heart failure,
- Cerebrovascular disease
- A high-risk operation
- Preoperative treatment with insulin
- Preoperative serum creatinine greater than 2.0 mg/dL
Pre-op hx of MI
- risk
- testing
- 5% to 10% risk of postoperative MI
- Preoperative EKG on patients 40+ yo
- Current unstable angina: avoid elective surgeries
- Stage two HTN: control prior to surgery
- Patient should take antihypertensive medication on the day of the procedure
- History of rheumatic heart disease: prophylactic antibiotic therapy
- Send the patient to a cardiologist for clearance to have a stress test or Echo if any concerns
when is noninvasive stress testing indicated (non-cardio procedures)
- Active cardiac conditions (eg, unstable angina, recent MI, significant arrhythmias, or severe valvular disease)
- Patients who require vascular operations and have clinical risk factors and poor functional capacity
what is the most common type of perioperative complication
pulmonary
What are the two main determinations of post-op risk?
- operative site
- Presence of lung disease
Optimal time to stop smoking pre-op
8 weeks
Asthma and perioperative risk
- well controlled
- not well controlled
- no additional risk
- risk factor if not well controlled
Asthma control
- any surgery
- elective surgery
- step up therapy including systemic steroids if needed based on FEV1 and PVC
- PEV >80% and wheeze free
Asthma control and endotracheal intubation
- rapid inhaled beta agonist 2-4 puffs or nebulizer 30 min prior intubation
what pulm situations are absolute contraindications to elective surgery? what to do in emergency situations
Acute lower resp tract infections:
- tracheitis
- bronchitis
- pneumonia
Emergency: humidification of inhaled gas, remove lung secretions, bronchodilators and abx
What type of surgery have highest risk of post-op pulmonary risk
- upper abdominal
- open aortic aneurysm
- open thoracotomy
- head/neck operations
Postop strategy to reduce risk of pulm complications
- lung expansion: PT, breathing exercises, incentive spirometry, etc.
- Early mobilization (facilitates deep breathing)
What does elevated glucose level increase risk for?
surgical site infection (SSI)
how to control glucose perioperative period
IV insulin
Glycemic control
Normal: 90-100
Moderate: 120-200
Renal disease
- CKD c dialysis: sig increase in post-op complications (hyperkalemia, pneumonia, fluid overload, bleeding)
- Dialysis 24 hours before surgery
- monitor electrolytes immediately before and after surgery
- monitor weight, I&Os, and renal function
Hepatic disease
complications
hemorrhage, infection, renal failure, encephalopathy, substantial mortality rate
Hepatic disease
- elective surgery
- reduce ascites: leads to wound dehiscence and hernias
- reduce encephalopathy: worsened by sedatives and analgesics
- reduce coagulopathy: vitamin K +/- plasma transfusion
Hepatic disease
- postop
- platelet number and function
- electrolyte disturbances, esp hypernatremia
- Risk for upper GI hemorrhage (esophageal or gastric varies)
- etoh: malnutrition and vitamin deficiencies
tobacco use risks
- decreases functional capacity
- increases risk of bleeding, infection, wound dehiscence
- increased risk of hernia recurrence
Chronic steroid use
- perioperative risks
- Postop infection, dehiscence, mortality, poor wound healing, staple line leaks
- Addisoninan crisis if inadequate pre-op dose
When should perioperative stress hormone be given ?
primary or secondary adrenal insufficiency
- current regimen of more than 20 mg prednisone
- monitor glucose levels!
Dx of DVT
- first line if low prob
- preferred
- D-dimer: >500 positive
- compression US with doppler: preferred
DVT
- management
- Anticoagulation
- IVC filter if risk of bleed > risk VTE
- LMWH if cancer
- Pregnancy: SQ LMWH or temp IVC filter
- Thrombectomy: massive iliofemoral or fail other management
DVT prevention
- early ambulation
2. compression stockings 2 years
PE
- screening tests (3)
- CXR: normal, +/- atelectasis or pleural effusion. **Hampton’s Hump and Westermark’s sign
- D-dimer
- EKG: S1Q3T3
PE
- diagnostic tests
- Helical CT
- doppler US (only helpful if positive…)
- VQ scan
- Increased A-a (alveolar-arterial) gradient
- CT pulmonary angiography (gold standard!!)
- ABG- resp alkalosis
what test is used first to establish dx of jaundice
Fractionated bilirubin
Jaundice
- pre-hepatic causes
red cell breakdown
- hemolysis
- erythropoiesis
- hematoma reabsorption
- myoglobin breakdown
Jaundice
- pre-hepatic often leads to what kind of bilirubin
unconjugated/indirect
Jaundice
- intrahepatic causes
- autoimmune
- infectious (hepatitis)
- genetic defects (Gilbert, Crigler-Najjar)
- Pharm
Jaundice
- posthepatic
- usu biliary obstruction
- infectious (cholecystitis, cholangitis)
- secondary to neoplasm around the biliary tract
Pheochromocytoma
- first test for high risk pt
plasma fractionated metanephrines
Pheochromocytoma
- first test for low risk pt
24 hour urine fractionated metanephrines
Pheochromocytoma
- associated disorders
Familial tumor disorders:
- MEN2
- von Hippel-Lindau
Pheochromocytoma
- triad
- palpitations/tachycardia
- episodic HA
- diaphoresis
*usu have hx of HTN
Pheochromocytoma
- testing after biochemical testing
- CT or MRI to locate tumor
- poss genetic testing
Pheochromocytoma
- What medication given pre-op
a-adrenergic blockade to prevent unopposed alpha agonism once give beta blocker
- phenoxybenzamine or phentolamine
Pheochromocytoma
- med given during sx
beta blocker: maintain CV and hemodynamic stability
MCC appendicitis
fecalith
Surgical site infection
- def by timing
- 30 days of procedure
- 90 days if prosthetic material is used
Surgical site infection
- RF
- smoking
- older
- obesity
- malnutrition
- DM
- immunosuppressed
Surgical site infection
- highest risk is sx of what location
abdominal
Then CABG, C-section, vascular, joint prosthesis
Cellulitis surgical site infection
- PE
- red, warm, purulent drainage
- no wound dehiscence or fluctuance
Surgical site infection Tx
- cellulitis
- abscess
- abx, no open drainage needed
- I and D
Burns
- Parkland formula
Ringers lactate = 4 ml X total BSA of burn % X body weight (kg)
- first half over first 8 hours
- second half of next 16 hours
Burn
- steps to tx
- ABCDE
- fluid resuscitation with Ringer’s lactate via Parkland formula
Medication to treat hemophilia A
DDAVP / desmopressin
analogue of vasopressin which promotes factor VII and VWF release from storage pools
how to give iron to a patient post bariatric surgery with risk of inadequate absorption
IV
for example post Roux-en-Y
What should be done pre-op for pts with COPD who have increased respiratory sx, reduced exercise tolerance, new lung auscultation findings?
CXR to r/o active infection and heart failure
Functional Capacity
- indicator of what
Postop cardiac complication risk
- assess at initial prep evaluation
- expressed in METs
Functional Capacity
- 4 levels of METs
1: can care for self: eat, dress, use toilet
3-4: walk up steps or hill, walk on level ground
4-10: heavy work around the house, climb two flights of stairs
>10: can do strenuous sports
Painless mass on testicle: diagnostic steps
- PE: painless mass
- trans-scrotal US
- CT scan
How much of a margin should excision of melanoma contain
2 cm margin
Esophageal stricture
- MCC
long standing gastric reflux: form at GE junction as part of healing process of ulcerative esophagitis and lead to narrowing of the lumen
Esophageal stricture
- clinical
dysphagia: slow progressive to solids
- regurgitation
- episodic food impaction
Esophageal stricture
- dx
- upper endoscopy: direct visualization of gastric mucosa
- biopsy during endoscopy to r/o malignancy
Esophageal stricture
- Tx
- dilation during endoscopy
- acid-suppressive therapy with PPI to prevent recurrence
Empiric therapy for cellulitis
should cover MRSA
- clindamycin
- Bactrim
- Tetracycline (doxy or mino)
clinical signs of perforation of acute cholecystits
hypoactive bowel sounds
- also high fever, toxic signs (tachycardia, tachypnea), rebound tenderness abd pain
DVT
- diagnostic test of choice
doppler US (will show non compressibility of imaged vein = thrombus)
DVT
- timing of presentation post surgery
more than one week postop
Nephrotic syndrome leads to edema of what area of the body
- non-ambulatory
- ambulatory
- sacrum
- peripheral (usu LE) and periorbital
Solitary thyroid nodule
- TSH
- first test
- if normal or high = thyroid US
Solitary thyroid nodule
- on US is benign
- serial f/u
Solitary thyroid nodule
- on US is malignant
- FNA
Solitary thyroid nodule FNA is
- benign
- indeterminate
- malignant
- serial f/u
- repeat FNA
- sx removal
Where do the majority of diverticula form?
sigmoid colon - highest pressure bc it has the smallest diameter of the colon