gen pharm

Question 1

why do NSAIDs have an “analgesic ceiling”

Answer 1

block of sensitization of nociceptor fibres rather than block of nociceptor signals

aka less signal, not no signal

Question 2

production time of TXA2 vs PGI2

Answer 2

TXA2 = 1 to 2 weeks
-> made by formation of new platelets

PGI2 = few hours
-> made by endothelial cells synthesis

Question 3

MOA of cyclosporine A

Answer 3

inhibit transcription of IL-2

Question 4

why is N-acetylcysteine used for treatment of paracetamol overdose

Answer 4

NAC replenishes glutathione which inactivates the toxic metabolite of paracetamol

Question 5

drugs that can cause stevens-johnson syndrome (aka toxic epidermal necrolysis)

Answer 5

allopurinol, sulfonamids (cotrimoxazole, sulfasalazine), anti-epileptic drugs (carbamazepine, lamotrigine, phenobarbitone, phenytoin)

Question 6

neostigmine side effects

Answer 6

SLUD

salivation
lacrimation
urination
defecation