endocrine

Question 1

permanent treatment for hyperthyroidism

Answer 1

radioiodine therapy (RAI) + lifelong levothyroxine

Question 2

hashimotos is what antibody

Answer 2

anti-thyroglobulin, anti-thyroid peroxidase

Question 3

graves is what antibody

Answer 3

anti-TSH receptor

Question 4

hashimoto’s predisposes to what cancer

Answer 4

malt lymphoma

Question 5

liothyronine vs levothyroxine, which one has better oral bioavailability?

Answer 5

liothyronine

Question 6

why levothyroxine preferred over liothyronine?

Answer 6

lower acute cvs risk

Question 7

which thioamide is preferred in thyrotoxicosis and why?

Answer 7

propylthiouracil, cuz inhibits peripheral deiodination of T4 to T3

Question 8

what is MEN2a?

Answer 8

multiple endocrine neoplasia (AD):

• medullary thyroid carcinoma
• pheochromocytoma
• parathyroid hyperplasia/adenomas
• cutaneous lichen amyloidosis (occasionally)

Question 9

woody hard thyroid, local to systemic fibrotic changes, IgG4 elevation

Answer 9

reidel’s thyroiditis

Question 10

hemispherical goitre, haematogenous spread to lung/bones

Answer 10

follicular carcinoma

Question 11

hemispherical goitre, lymphadenopathy

Answer 11

papillary carcinoma