Gazzerro - Skeletomotor system Flashcards
(31 cards)
Name at least two ways that voluntary movement differs from reflexes.
- voluntary mvmt is governed by conscious planning
- it is organized around performance of a specific task
- task performance becomes more efficient w experience
- voluntary mvmt can be initiated internally w/o a sensory stimulus trigger
- sensory stimuli do not dictate the resulting mvmt, although they guide the specified task
The motor system follows a hierarchical processing. What pathway is this called?
The descending lateral corticospinal pathway.
What brain areas are involved in the planning of movement?
Associative cortex and the limbic system
What is motor equivalence and what is an example?
-the ability to use different movements, produced by either the same or different parts of the body, to perform a task under different conditions
For example, a persons handwriting is a similar style regardless of the limb used to write. (even arm, teeth, foot, style is somewhat conserved)
What is included in the term ‘kinematic information’?
-includes the position, velocity, and acceleration of the hand, joint angles and muscle length without reference to the force (muscle spindles)
What is the primary motor cortex (M1) area 4 involved in?
Direction, force, and velocity of mvmt.
What brain area is involved in the planning and anticipation of a specific motor act?
premotor area
What brain area is involved in the programming of motor sequences?
supplementary motor area (SMA)
The lateral corticospinal tract is involved in…
A. mostly limb control
B. proximal muscle control, mostly upper body
C. trunk control
A. mostly limb control
The ventral corticospinal tract is involved in…
A. mostly limb control
B. proximal muscle control, mostly upper body
C. trunk control
B. proximal muscle control, mostly upper body
The medial cortial motor path is involved in…
A. mostly limb control
B. proximal muscle control, mostly upper body
C. trunk control
C. trunk control
-innervation of the trunk and proximal muscles of the upper arms
Grey and white matter development begins
A. from 20 weeks gestation
B. from birth
C. from 1 year
D. from 20 years
A. from 20 weeks gestation
Cortical thickness and surface area of the brain begins to develop
A. from 20 weeks gestation
B. from birth
C. from 1 year
D. from 20 years
B. from birth
Grey and white matter expansion of the brain begin postnatally.
A. true
B. false
A. true
Myelin development begins prenatally.
A. true
B. false
B. false
-at 3 months there are very immature myelin structures
-around 3 years myelin reaches final stage
(very slow development)
What are the 4 types of motoneurons based on functional classification?
alpha-FF –> fast twitch fatiguable (Type II6/x)
alpha FR –> fast twitch fatigue resistant (Type IIa)
alpha S –> slow twitch (Type I)
gamma –> intrafusal
What are the alpha motor neurons responsible for?
the contraction of the muscle
What are the gamma motor neurons responsible for?
the activation of the muscle spindle
How can you differentiate between an upper and a lower motorneuron disease?
Upper MN: Lower MN:
- hypertonia -hypotonia
- hyperreflexia -hyporeflexia
- clonus
- atrophy -atrophy
- babinsky sign + -babinsky sign -
What is a Babinsky sign?
- a reflex occurs after the sole of the foot has been firmly stroked. The big toe then moves upward or toward the top surface of the foot.
- a positive Babinski sign happens when the big toe bends up and back to the top of the foot and the other toes fan out –> may indicate damage to the CNS
- it is not normal to have a reflex stronger on one side than the other
What are the signs of an upper motor lesion and what are some examples of conditions that involve upper motor lesions?
-an increase in responsiveness, no inhibitory control of motor neurons –> muscle contractions
Examples:
- ischemic or hemorragic stroke (acute presentation)
- HTLV-1 assoc Myelopathy (spastic tropical paraparesis)
- prion disease
- familiar spastic paraplegia (increased tone)
- ALS (high degree of impairment of upper MN but also an impairment of the lower MN)
What are the signs of a lower motor lesion and what are some examples of conditions that involve upper motor lesions?
-decreases in tone, reflexes, and muscle mass
Examples:
- poliomyelitis and post-polio syndrome
- motor Guillain Barre syndrome
- multifocal motor neuropathy
- myopathies
- spinal muscular atrophy
- Kennedy syndrome
Select all that are correct.
Spinal Muscular Atrophy…
A. is a disease of the upper motor neurons
B. is a disease of the lower motor neurons
C. is characterized by irreversible loss of the anterior horn cells in the spinal cord and the brain stem nuclei
D. may be caused by autosomal dominant inheritance
E. linked to autosomal recessive inheritance of 5q13.2
B. is a disease of the lower motor neurons
C. is characterized by irreversible loss of the anterior horn cells in the spinal cord and the brain stem nuclei
E. linked to autosomal recessive inheritance of 5q13.2
Why does SMN1 more often lead to a functional SMN protein than SMN2?
- the presence of ‘c’ is critical for the splicing events of exon 7
- in SMN2 there is no ‘c’ –> instability of the splicing system. 85% of the transcript loses exon 7, leading to a non functional, truncated SMN protein. 15% remains to become a functional SMN protein
