gate past year questions BT Flashcards
Eukaryotic transcription is carried out by
DNA-dependent RNA polymerase
Acetylcholine released by the parasympathetic nerves has which one of the
following functions in the heart pacemaker cells?
It binds to GPCR and activates G protein to slow the heart rate
Determine the correctness or otherwise of the following Assertion [a] and the
Reason [r].
Assertion [a]: In multicellular organisms, cells of different lineages have different
gene expression profiles.
Reason [r]: Alternative splicing is the only mechanism to generate protein
diversity
[a] is true but [r] is false
Determine the correctness or otherwise of the following Assertion [a] and the
Reason [r].
Assertion [a]: Chromosome mutations can change the structure of chromosomes.
Reason [r]: All chromosome mutations arise due to nondisjunction of
chromosomes during mitosis or meiosis.
a] is true but [r] is false
C-value paradox refers to
the lack of correlation between genome size and genetic complexity of an
organism
Which one of the following drugs is NOT an immune checkpoint inhibitor?
Trastuzumab
Dendritic cells are involved in cross-presentation of antigens. Which of the
following protein(s) is(are) required for cross-presentation?
Basic leucine zipper ATF-like transcription factor 3 (BATF3)
riant chain peptide (CLIP)
What cell is required for the development of B-cells in the bone
marrow?
stromal cells
leghemoglobin
binds oxygen to protect nitrogenase
The correct sequence of events during bacteriophage infection of a bacterial cell is
landing → attachment → tail contraction → penetration and unplugging → DNA
ejection
Intracellular proteins are targeted for proteolytic degradation in proteasomes upon
conjugation with
ubiquitin
In ELISA, which of the following enzymes are conjugated to antibodies for
detection of the analyte?
Alkaline phosphatase Horseradish peroxidase
In hybridoma technology, which one of the following enzymes is absent in the
myeloma cells that are used for monoclonal antibody production?
Hypoxanthine-guanine phosphoribosyltransferase
Which of the following methods are used for detection of DNA and RNA,
respectively?
Southern and Northern blotting
mRNA
. Codes for proteins
rRNA
Forms the core of the ribosome structure and
catalyzes protein synthesis
miRNA
Regulates post-transcriptional gene
expression
tRNA
serves as adaptors between mRNA and
amino acids during protein synthesis
Which one of the following programs is used for finding distantly related (or
remote) protein homologs?
PSI-BLAST
Which one of the following is used for global alignment of two protein sequences?
Needleman-Wunsch algorithm
Which one of the following plant growth regulators facilitate adventitious root
formation?
Auxin
Fabry disease in humans is a X-linked disease. The probability (in percentage) for
a phenotypically normal father and a carrier mother to have a son with Fabry
disease is
25%
anergy
Unresponsiveness to antigens due to
lack of co-stimulatory molecules
activation-induced cell death
Elimination of activated T-cells
after antigen clearance
Receptor editing
Elimination of auto-reactive B-cells
Regulatory T-cells
. Inhibition of auto-reactive T-cells at
periphery
Xerophile
low water
mesophile
20 - 45 c
halophile
high salt conc
T4 bacteriophage genome
dsDNA
SARS-CoV-2 genome
ssRNA
Pseudomonas phage phi6 genome
dsRNA
phiX174 bacteriophage
dsRNA
The event(s) that lead(s) to inactivation of tumor suppressor genes in cancer cells
is(are)
gene amplification
(B) promoter methylation
(C) loss of heterozygosity
Methylation of CpG islands near the promoter of a gene can inhibit transcription
by
(A) preventing RNA polymerase binding
(B) facilitating repressor binding
(C) facilitating heterochromatin formation
induced pluripotent stem
cells
A) They can self-renew
(B) They require specific signals to maintain their stemness
(C) They can form organoids in vitro
fluoroquinolone drugs
(A) They contain quinolone ring(s)
(B)They bind to bacterial topoisomerase
plant protoplast fusogenic agent
(A) Sodium nitrate
(B) Polyvinyl alcohol
(C) Polyethylene glycol
Direct DNA transfer method(s) used for plant genetic engineering is(are)
(A) microparticle bombardment
(B) electroporation
(C) polyethylene glycol treatment
vectors used to clone a DNA fragment of size
220 kb
BAC, cosmids
DNA sample collected from an unidentified bacterial species (Y) contains 13% of
adenine. The G+C content (in percentage) of Y is ___________.
74
