Gastrulation Flashcards
Cell adhesion molecules
CAMs
Cell surface proteins involved in specific interactions allowing differential cell adhesion
Give 3 examples of cell adhesion molecules
Cadherins
Immunoglobin superfamily proteins
Integrins
Name 4 types of cell-cell adhesions
Adherens junctions
Desmosome
Calcium dependent adhesion
Cell matrix adhesion
Describe the structure of a cadherin molecule
Diner formed via interaction between the two EC1 domains
Part of a large and diverse family
Generally bind homophillically
N-cadherin is specific to neurons
Give 4 essential cell processes that take place during or after gastrulation
Cell proliferation, specialisation, movement, interactions
Define gastrulation
The process in animal embryos in which prospective endodermal and mesodermal cells move from outer surface of the embryo to the inside where they give rise to internal organs
Gastrula
The stage in animal development in which prospective endodermal and mesodermal cells of the blastula or blastoderm move inside the embryo
Invagination
Type of cell movement during gastrulation
Infolding of cell sheet into embryo
Eg sea urchin endoderm
Involution
Type of cell movement during gastrulation
Inturning of cell sheet over the basal surface of an outer layer
Eg amphibian mesoderm
Ingression
Type of cell movement during gastrulation
Migration of individual cells into the embryo
Eg. Sea urchin mesoderm, drosophila neuroblasts
Delamination
Type of cell movement during gastrulation
Splitting or migration of one cell sheet into two
Eg mammalian hypoblast
Epiboly
Expansion of one cell sheet over other cells
Eg ectoderm formation in amphibians, sea urchins and tunicates
Convergent extension
Mechanism that elongates a sheet of cells in one direction while narrowing its width
Occurs by rearranging cells within the sheet rather than by cell migration or division
Dissociated cells expressing different amounts of _____________ reassort themselves into ______________.
Cells with _________ n-cadherin molecules cluster on the ______ of the aggregation. Cells expressing ________ stay at the __________.
N cadherin Distinct spatial domains More Inside Less Periphery
Ectoderm
Epidermis and related structures
Skin Hair Nails Brain NS