Gastrointestinal Ulcers

Question 1

Cimetidine

Answer 1

histmaine-2 antagonist, block H2 receptors in parietal cells to inhibit action of proton pump and reduce acid secretions

Question 2

Omeprazole

Answer 2

proton pump inhibitors, irreversibly bind to proton pump for lifetime of the protein to inhibit H+ pumped into stomach lumen

Question 3

Antacids (Al, Mg, Ca, Na Bicarbonate)

Answer 3

neutralize protons in stomach lumen to rasie pH

Question 4

Sucralfate

Answer 4

bind to ulcer and form gel with mucus in low pH

Question 5

misoprostol

Answer 5

synthetic prostaglandin has cytoprotective activity