gastrointestinal alginates and antacids

Question 1

alginates and antacids indications

Answer 1

GORD - symptomatic relief of heartburn

Dyspepsia- for short term relief of indigestion

Question 2

how do antacids and alginates work

Answer 2

• antacids buffer stomach acids
• alginates increase viscosity of stomach contents
• reduce reflux of stomach acid into oesophagus
• after reacting with stomach acid they form a floating raft which separates gastric contents from gastro oesophaegeal junction to prevent mucosal damage

Question 3

how do antacids and alginates work

Answer 3

• antacids buffer stomach acids
• alginates increase viscosity of stomach contents
• reduce reflux of stomach acid into oesophagus
• after reacting with stomach acid they form a floating raft which separates gastric contents from gastro oesophaegeal junction to prevent mucosal damage

Question 4

magnesium salts cause

Answer 4

diarrhoea

Question 5

magnesium salts cause

Answer 5

diarrhoea

Question 6

aluminium salts cause

Answer 6

constipation

Question 7

aluminium salts cause

Answer 7

constipation

Question 8

are alginates safe in pregnancy

Answer 8

yes

Question 9

are alginates safe in pregnancy

Answer 9

yes

Question 10

paediatrics, compound alginates should not be given with… because

Answer 10

thickened milk preparations can lead to excessively thick stomach contents that cause bloating and abdominal discomfort

Question 11

paediatrics, compound alginates should not be given with… because

Answer 11

thickened milk preparations can lead to excessively thick stomach contents that cause bloating and abdominal discomfort

Question 12

what electrolyte imbalance can sodium and potsssium or gluoce containing preparations cause and which patient group should this be used in caution with

Answer 12

hyperkalaemia
hyperglycaemia
fluid overload
renal failure
diabetics

Question 13

how long of a gap between taking antacids and alginates with other medications

Answer 13

2 hours

Question 14

antacids interact with drugs such as ? and how?

Answer 14

cations in compound alginates can bind to other drugs, reducing their absorption

antacids can reduce serum conc of other drugs such as
- ace inhibitors
- antibiotics such as - cephalosporins, ciprofloxacin, tetracyclines
- bisphosphonates
- digoxin
- levothyroxine
- proton pump inhibitors

Question 15

antacids interact with drugs such as ? and how?

Answer 15

cations in compound alginates can bind to other drugs, reducing their absorption

antacids can reduce serum conc of other drugs such as
- ace inhibitors
- antibiotics such as - cephalosporins, ciprofloxacin, tetracyclines
- bisphosphonates
- digoxin
- levothyroxine
- proton pump inhibitors

Question 16

by ? mechanism of action, antacids can increase the excretion of ?

Answer 16

• antacids increase the alkalinity of urine and can increase the aspirin and lithium