endocrine bisphosphonates

Question 1

common side effects of bisphosphonates

Answer 1

• oesophagutis
• hypophosphataemia
• osteonecrosis of the jaw (more likely with high dose IV therapy) counsel about good dental care
  -atypical femoral fracture

Question 2

bisphosphonates warnings

Answer 2

• severe renal impairment
• hypocalcaemia
• upper GI disorders
• osteonectosis risk: smokers and dental disease

Question 3

important interactions for bisphosphonates

Answer 3

• calcium salts
• antacids
• iron salts

Question 4

counselling on administration of oral bisphosphonates

Answer 4

• swallowed at least 30 mins before other medications
• taken with plenty of water
• remain upright for 30 mins after administration to avoid oesophageal irritation