GastroIntestinal Flashcards
Know G.I.
Dysphagia
Difficulty swallowing
Odynophagia
Pain with swallowing
Esophageal Webs
- Associated with Iron Deficiency Anemia
- Glossitis
(Plummer-Vinson Syndrome)
Dysphagia
Dx
Esophageal Dysphagia:
- Barium Swallow followed by
- endoscopy
If obstructive lesion shows then BIOPSY
Diffuse Esophageal Spasm
Motility disorder which normal peristalsis is periodically interrupted by high amplitude nonperistaltic contractions
Diffuse Esophageal Spasms
HX / PE
- Chest Pain
- Dysphagia
- Odynophagia
- Precipitated by ingestion of hot or cold liquids
- relieved by nitroglycerin
Diffuse Esophageal Spasms
Dx & Tx
Dx- Barium Swallow (cork screw esophagus)
Tx- Nitrates and CCB’s
- Surgery for SEVERE problems
Achalasia
Impaired relaxation of lower esophageal sphincter (LES)
Achalasia
Hx / PE
- Progressive dysphagia
- Chest pain
- Regurgitation of undigested food
- Weight loss
- Nocturnal cough
Achalasia
Dx
1st- Barium Swallow : shows dilation, “birds beak”
- Manometry shows increase resting LES pressure
Achalasia
Tx
Nitrates
CCB’s
Inject botulinum into LES
Pneumatic balloon dilation or surgical myotomy
Esophageal Cancer
- Squamous Cell Carcinoma (SCC) is most common.
- Adenocarcinoma is most prevalent in USA (Barrett’s Esophagus)
Esophageal Cancer
Hx / PE
- Progressive dysphagia (solids first then liquid)
- Weight Loss
- GERD
- GI Bleeding
Esophageal Cancer
Dx
1st- Barium Study
2nd- Biopsy confirms
- CT and Endoscopic used for staging
Esophageal Cancer
Tx
- ChemoRadiation and surgical resection if definitive tx
- Prognosis is poor
Cancer Metastasizes early because esophagus lacks a serosa
GastroEsophageal Reflux Disease (GERD)
Reflux of gastric contents into the esophagus
- from transient LES relaxtion
- due to incompetent LES, Gastroparesis or Hiatal hernia
GERD
Dx
Hx and Clinical impression
- Trial of lifestyle modification and tx attempted first
- Studies maybe a Barium Swallow to look for Hiatal hernia
- EGD with biospy should be done in pt with symptoms unresponsive to initial therapy
GERD Tx
Liftstyle Change
- Weight loss
- Head of bed elevation
- Reduce meal size
- Avoid Noctural meals
Pharm
- Antacids
- H2 antagonists (cimdetidine) or PPI (omeprazole) in chronic and frequent symptoms
- Surgical (Nissen Fundoplication) for SEVERE disease
GERD Avoid what types of food
- Caffeine
- Alcohol
- Chocolate
- Garlic
- Onions
- Mints
- Nicotine
Hiatal Hernia
Herniation of a Portion of stomach upwards into the chest through a diaphragmatic opening
- Sliding (95%)- Gastroesophageal junction and portion of stomach displaced above diaphram
- Paraesophageal (5%)- Gastroesophgeal remains below diaphram, but portion of fundus goes into mediastinum
Hiatal Hernia
Dx / PE
May be asymptomatic
Sliding may present with GERD
Hiatal Hernia
Dx a& Tx
Dx- Commonly incidental finding on CXR
- DX by Barium Swallow or EGD
Tx-
Sliding- Medical Therapy and life style mods
to decrease GERD
Paraesophageal- Surgical gastropexy (Attach stomach to rectus sheath and closure of hiatus)
Gastritis
Inflammation of the stomach lining
Gastritis
Subtypes (3)
Acute: rapid develop
- Due to NSAIDS
- Alcohol
- H. Pylori
- Stress
Chronic Type A (10%)
- Occurs in Fundus
- Due to Autoantibodies of parietal cells
- causes Pernicious anemia
Chronic Type B (90%)
- Occurs in Antrum
- Due to NSAIDS or H. Pylori
Gastritis
Hx / PE
Maybe Asymptomatic
- epigastric pain
- Nausea
- Vomiting
- Hematemesis
- Melena
Gastritis
Dx
Upper Endoscopy visulizes gastric lining
H. Pylori detect by Urease Breath Test
- IgG indicates exposure
Gastritis
Tx
- Antacids, H2 blockers, PPI
- Triple Therapy
(Amoxicillin, Clarithromycin, Omeprazole) - Prophylactic H2 or PPI for risk of stress ulcers
Gastric Cancer
Tumors generally Adenocarcinoma
2 types
- Intestinal: arises by H. pylori
- Diffuse- Signet Sing Cells seen
Gastric Cancer
Hx / PE
Early Signs
- Indigestion
- Loss Appetite
Advanced
- Ab pain
- Weight loss
- Upper GI bleed
Gastric Cancer
Dx & Tx
Early
- discovered serendipitously with endoscopic exam
Tx- successful tx rests on early detection and surgical removal
5 year survival rate <10% in advanced disease
Peptic Ulcer Disease (PUD)
Damage to gastric or duodenal mucose
caused by impaired mucosal defense and/or gastric contents
PUD
Hx / PE
Duodenal Ulcers
- Dull
- Buring epigastric pain
- Improves with means
Gastric
- Pain right after meals
- “Coffee ground emesis)
- Blood in stool
Gastric Cancer
Has Virchow’s Node
what is it located
Enlarged Left SupraClavicular Lymph Node
PUD
PE
- Exam reveal epigastric tenderness
- Stool guaiac
- Acute perforation can present with rigid abdomen
- rebound tenderness
- Guarding
- peritoneal irritation
PUD
DX
- AXR rule out perforation (free air under diaphram)
- CBC assess for GI bleed (Low hematocrit)
- Upper Endoscopy with biopsy to confirm PUD
- H. Pylori test
PUD
Tx
Acute
- rule out active bleed with Serial Hematocrits
- Rectal exam with stool guaiac
- Monitor B.P.
- Perforation- SURGICAL
Pharm
- Protect Mucosa
Mild
- Antacids
- Misoprostal for mucosal production
- Pt with H. Pylori (give triple antiobiotics)
- Dicontinue exacerbating agents
Endoscopy and Surgery
- Symptoms for > 2 months and refractory
Diarrhea
4 etiologic mechanisms?
Production of > 200 g of feces per day along with increase frequency or decrease consistency of stool
4 etiologic mechanisms
- Increase motility
- Increase Secretion
- Increase luminal osmolarity
- Increase inflammation
Diarrhea
He / PE
Acute
- < 2 weeks of symptoms
- usually infectious and self limited
Preformed Toxins
- S. Aureus
- Bacillus
Non-invasive
- E-coli
- Vibrio
- C. Difficle
Invasive - Enteroinvasive E-Coli - Salmonella - Singella Campylobacter
Parasite
- Giardia
- Entamoeba Histolitica
Peds
- Rotavirus (common during winter)
Chronic Diarrhea
Insidious onset
>4 week of symptoms
Due to increase secretion (carcinoid, vipoma)
Malabsorption/osmotic
- Bacterial overgrowth
- Pancreatic insufficiency
- lactose intolerance
Inflammatory Bowel Disease
Diarrhea
DX
Acute
- No lab required
- No investigation unless high fever, blood and > 5 days
- Consider SIGMOIDOSCOPY in patients with bloody diarrhea
Diarrhea
TX
Acute
- no bacterial infection
- treat with antidiarrheal (loperamide) and ORAL rehydration
Chronic
- Identify underlying cause
- tx symptoms
- loperamide
- opioids
Peds
- Hospitalize
- IV fluids
- repleate Electrolytes
Carcinoid Syndrome
Due to liver metastasis of Carcinoid Tumors
Arise from Ileum and Appendix
Produce vasoactive substances like serotonin and substance P.
Carcinoid Syndrome
HX / PE
- Cutaneous flushing
- Diarrhea
- Ab cramps
- Wheezing
- Right sided valvular heart lesions
Carcinoid Dx
High urine levels of
5-HIAA (serotonin Metabolite)
Carcinoid Tx
Octreotide (for symptoms)
Debulking of tumor mass
Small Bowel Obstruction (SBO)
Blocked passage of bowl contents through the small bowel.
Leading to fluid and electrolyte imbalances, ab discomfort
Obstruction can be
- Complete
- Partial
&
- Ischemic
- Necrosis