Dermatology Flashcards
Know Dermatology
Skin has 3 layers, what are they?
Epidermis
Dermis
Subcutaneous Tissue
Atopic Dermatitis
Eczema
Relapsing inflammatory skin disorder
ITCH THAT RASHES
Atopic Dermatitis characterized by?
Pruritus that leads to lichenification
Atopic Dermatitis Hx/Pe
Associated with:
Asthma
Allergic Rhinitis
Risk of bacterial and viral infections
Atopic Dermatitis Triggers
Climate Food Allergens Physical / Chemical irritants Emotional Factors
Macule
Flat lesions that differers in colour from surrounding skin
<1 cm diameter
Papule
Elevated solid lesion <5mm
Patch
Small circumscribed area differing in colour from surrounding surface >1cm
Plaque
Elevated solid lesion >5mm
Cyst
Epithelial lines sac containing fluid
Vesicle
Fluid filling, very small <.5mm elevated lesion
Bulla
Large vesicle >5mm
Wheal (hive)
Area of localized edema that follows vascular leakage and usually disappears within hours
Lichenification
Thickening of the epidermis
Scar
Healing defect of the dermis
The Epidermis alone heals without a scar
Hypersensitivity Reaction
Type I
Anaphylactic or Atopic
- Antigen cross-links IgE on PREsensitized mast cells and basophils
Triggers release of vasoactive amines (Histamine)
First and Fast
Examples- Anaphylaxis
- Asthma - Wheals
Types I, II and III are all antibody or B-cell mediated
Hypersensitivity Reaction
Type II
Cytotoxic
- IgM and IgG bind to antigen on “enemy cell” leading to Lysis (by compliment) or phagocytosis.
Examples- Autoimmune Hemolytic Anemia
- Rh Disease - GoodPastures - Rheumatic Fever
CY-2-Toxic
Antibody and complement lead to MAC
Hypersensitivity Reaction
Type III
Immune Complex
Antigen-Antibody complex activate complement which attracts Neutrophils. Neutrophils release lysosomal enzymes
Examples: Polyarteritis nodosa SLE Rheumatoid Arthritis Serum Sickness (Blood) Arthus Reaction (Vaccines)
Hypersensitivity Reaction
IV
Delayed (Cell Mediated)
Sensitized T lymphocytes encounter antigen and then release lymphokines (macrophage activation).
Examples: TB skin test
Transplant rejection
Contact dematitis
Atopic Dermatitis Dx
Made clinically
Mild eosinophilia
Increase IgE
Atopic Dermatitis Tx
Prophylactic measures
- non-drying soap
- Apply Moisturizers
Treat with topical steroids (don’t use longer than 3 weeks)
Contact Dermatitis
Type IV hypersensitivity Reaction
Results from contact with allergen which the pt has had previously been exposed and sensitized too
Contact Dermatitis Hx / PE
rash and pruritus
Allergens frequently include:
- poison ivy
- poison Oak
- Nickel
- Soaps
- Detergents
- Cosmetics
- Rubber Latex
Occurs where allergen touches
Contact Dermatitis Tx
Prophylaxis consists of Avoidance
Give- Topical or systemic steroids as needed
- wet, cool compresses to relieve and debride the skin