Gastrointestinal Flashcards
What is a Schatzki?
When B ring (mucosal ring below vestibule) is narrowed (<13mm) AND symptomatic (dysphagia)
Level of upper oesophageal sphincter
C5-6
Muscle which makes up the upper oesophageal sphincter
Cricopharyngeus
Barrett’s is a precursor to what malignancy?
Adenocarcinoma
Reticular mucosal pattern is found in what?
Barrett’s oesophagus
High stricture with an associated hiatal hernia
Barrett’s oesophagus
Young patient with atopia and eosinophilia with long history of dysphagia
Eosinophilic oesophagitis
Ringed oesophagus is feature of what?
Eosinophilic oesophagitis
Treatment for eosinophilic oesophagitis
Steroids
Concentric rings in oesophagus on barium?
Eosinophilic oesophagitis
Where is the most common location of oesophageal squamous cell carcinoma?
Middle third oesophagus
Arises from mucosa
(More common in afro-Caribbean males)
What are the risk factors for squamous cell carcinoma of the oesophagus?
Drinking
Smoking
Radiotherapy
Alkaloid ingestion
Where is the most common location for an oesophageal adenocarcinoma?
Majority in lower third of the oesophagus and arises from columnar epithelium or submucosal glands
What are the risk factors for oesophageal adenocarcinoma?
Reflux
Scleroderma
Drinking
Smoking
What is the difference between T3 and T4 cancer of oesophagus?
T3 is invasion of adventitia
T4 is invasion to adjacent structures
What are the risk factors for oesophageal candidiasis?
Immunocompromised (HIV/ transplant)
Achalasia
Scleroderma
What are the barium findings of oesophageal candidiasis?
Discrete plaque-like lesions.
Muscosal inflammation and oedema (nodularity, granularity, fold thickening).
Looks “shaggy” when severe.
What is the diagnosis in an asymptomatic elderly patient with imaging findings similar to that of oesophageal candidiasis?
Glycogen acanthosis
What are the barium findings in oesophageal herpes ulcer?
Small/ multiple punctate or linear ulcers with surrounding radiolucent halo
What are the risk factor(s) for herpes oesophagitis?
Immunocompromised patients, particularly those with AIDS
What are the cause(s) of uphill varices?
Portal hypertension
(confined to bottom half of oesophagus)
What are the cause(s) of downhill varices?
SVC obstruction (catheter related or tumour related)
Confined to top half of oesophagus
How can you differentiate between varices and varicoid carcinoma on imaging?
Varices will flatten out with a large barium bolus.
What are the appearances of varices on barium?
Linear, serpentine filling defects causing scalloped contour.
Water density posterior mediastinal cyst. Diagnosis?
Oesophageal duplication cyst
(Most common location is ileum)
What is the name given to a posterior hypopharyngeal diverticulum at the site of Killian dehiscence?
Zenker diverticulum
Dilated submucosal glands that cause multiple small out-pouchings usually due to chronic reflux. Diagnosis?
Oesophageal pseudodiverticulosis
What is the difference between traction and pulsion diverticulum?
Traction- triangular and will empty.
Pulsion- round and will not empty (contain no muscle in their walls).
What is a “feline oesophagus”?
Fine transverse folds coursing the oesophagus
Can be normal or associated with oesophagitis
Oesophageal web is a risk factor for what?
Oesophageal and hypopharyngeal carcinoma
What are the features of Plummer-Vinson syndrome?
Oesophageal web
Dysphagia
Weight loss
Thyroid issues
Iron deficiency anaemia
What is achalasia?
Motor disorder of distal 2/3 of the oesophagus where the lower oesophageal sphincter won’t relax.
What is the differential for a dilated oesophagus with smooth stricture at the GOJ junction?
Achalasia
Chagas disease
Pseudoachalasia
Scleroderma
Dilated oesophagus with signs of reflux and lung changes (NSIP). Diagnosis?
Scleroderma
What are the causes of a long stricture?
NG tube in too long
Radiation
Caustic ingestion
Dilated oesophagus due to cancer at GOJ junction is called what?
Pseudoachalasia
Name the three variants of familial adenomatous polyposis (FAP)?
Gardner syndrome
Attenuated familial adenomatous polyposis
Familial polyposis coli
Syndrome characterised by multiple colonic polyps and increased risk of colon and CNS tumours (glioblastoma/ medulloblastoma).
Turcot syndrome
Autosomal dominant polyposis syndrome resulting in cancer pretty much everywhere.
Lynch syndrome
(hereditary non-polyposis colorectal cancer)
What is the most common benign tumour of the stomach?
Leiomyoma
(can be calcified)
A patient undergoes a double-contrast barium meal examination which demonstrates multiple filling defects. On endoscopy, the filling defects were confirmed as multiple gastric polyps.
What is the most likely histological pattern?
A. Adenomatous polyps
B. Metastases
C. Hyperplastic polyps
D. Leiomyoma
E. Hamartomatous polyps
Hyperplastic polyps.
(Occur mainly in the body and fundus, measure less than 1cm, make up around 80-90% of gastric polyps and are a recognised complication of long term PPI use)
A gastric ulcer was visible during a double-contrast barium meal examination.
Which of the features below favour a benign aetiology?
A. Irregular modular folds
B. Shallow
C. Hamptons line
D. No protrusion beyond the stomach
E. Asymmetry
Hamptons line
(thin translucent line at the edge of an ulcer)
What is the most common benign tumour of the duodenum?
Adenoma
“Hide bound pattern” is seen in which condition?
Scleroderma
What cancers are people with achalasia more at risk of?
Squamous cell carcinoma
Oesophageal stricture with dilated submucosal gland. Diagnosis?
Pseudodiverticulosis.
Usually due to chronic reflux oesophagitis
What is the most common mesenchymal tumour of the GI tract?
Gastrointestinal stromal tumour (GIST)
“Jejunal ulcers” is buzzword for which syndrome?
Zollinger-Ellison syndrome
What is Carney’s triad?
Chondroma
Extra-adrenal pheochromocytoma
GIST
Which cancers most frequently metastasise to liver?
Colorectal, lung, breast
Less frequently:
Thyroid, Ewing’s sarcoma, neuroendocrine, renal cell, prostate
What are the CT findings in focal nodular hyperplasia (FNH)?
Arterial phase-low attenuation “scar” in centre of large hypervascular mass
No wash out
Venous phase-same scar “fills in”- as it contains central veins
What is the most common type of hypervascular liver metastasis?
Neuroendocrine
What are Aphthoid ulcers?
Shallow puncate “spot” with mucosal oedema
Aphthoid ulceration is found in which disorders?
Crohn’s disease
Yersinia enterocolitis
CMV enterocolitis
Amoebic enterocolitis
Polyarteritis nodosa (PAN)
Ischaemic colitis
Behçet’s disease
What are the causes of pseudosacculations?
Scleroderma
Crohn’s disease
What is Mirizzi syndrome?
When the hepatic duct is obstructed secondary to an impacted cystic duct stone. The stone can eventually erode into the CHD or GI tract.
Mirizzi syndrome occurs more in patients with which anatomical variant?
Low insertion of the cystic duct
What are the 5 types of choledochal cysts?
Type 1 : focal dilation of CBD (most common)
Type 2 : diverticulum of bile duct
Type 3 : choledochocele
Type 4 : intra + extra-hepatic
Type 5 : Caroli’s - intrahepatic only
“Comet-tail” artefact in the gallbladder is specific for what?
Adenomyomatosis
What other conditions are associated with Caroli disease?
Hepatic fibrosis (Caroli syndrome)
Polycystic kidney disease (AD and AR)
Medullary sponge kidney
Southeast Asian patient with dilated biliary ducts full of pigmented stones.
Ducts were described as “straight rigid intrahepatic ducts”
What is the diagnosis?
Recurrent pyogenic cholangitis
Which antibodies are present in primary biliary cirrhosis?
Antimitochondrial antibodies
(in 95%)
How can you differentiate between AIDs cholangiopathy and primary sclerosing cholangitis (PSC)?
Both have intrahepatic and extrahepatic strictures, AIDS is also associated with papillary stenosis
Extrahepatic strictures in AIDs > 2cm, whereas they are rarely > 5mm in PSC.
PSC has saccular deformities of the ducts.
What are the normal vascular US findings following liver transplant?
Rapid systolic upstroke (diastolic → systolic in less than 0.08s)
Resistive index 0.5 - 0.7
Hepatic artery peak velocity < 200 cm/sec
The liver and which other organ is involved in primary haemochromatosis?
(genetic increased gastrointestinal uptake of iron)
Primary = pancreas
The liver and which other organ is involved in secondary haemochromatosis?
(chronic inflammation/ multiple transfusions)
Secondary = spleen
What are the causes of massive caudate lobe hypertrophy?
Budd Chiari
Primary sclerosing cholangitis
Primary biliary sclerosis
What is the differential for decreased early enhancement of the periphery of the liver with delayed enhancement of the periphery, also called “nutmeg liver”?
Budd Chiari
Hepatic veno-occlusive disease
Congenstive hepatopathy(right heart failure, constrictive pericarditis, pulmonary hypertension)
What are the imaging features of the liver in haemochromatosis?
Liver is T1 and T2 dark
Drop out on IN phase imaging (opposite of fat)
Iron = in
What are the causes of hypervascular liver metastases?
Renal
Melanoma
Carcinoid
Choriocarcinoma
Thyroid
Islet cell
What are the risk factors for hepatic angiosarcoma?
Polyvinyl chloride
Arsenic
Radiation
Thorotrast
Associated with haemochromotosis and neurofibromatosis type 1
What are the risk factors for cholangiocarcinoma?
Primary sclerosing cholangitis
Recurrent pyogenic cholangitis
Clonorchis sinensis (East China)
HIV, Hep B&C
Alcohol
Thorotrast
What are the imaging features of a fibrolamellar HCC (subtype seen in younger patients <35)?
T2 dark with a non-enhancing central scar
Gallium avid
Calcifies more than conventional HCC
Not associated with elevated AFP or cirrhosis
In which situations would you find a hepatic adenoma?
Oral contraceptive use
Anabolic steroids
Glycogen storage disease
Obesity
Metabolic syndrome
Diabetes
What is the only hepatic lesion that is avid on sulfur colloid scan?
Focal nodular hyperplasia (FNH)
What is the difference between the central scar of focal nodular hyperplasia vs central scar of fibrolamellar HCC?
The central scar of FNH is T2 bright and enhances on delayed scans
The central scar of fibrolamellar HCC is usually T2 dark with no enhancement.
What are the imaging features of focal nodular hyperplasia (FNH)?
Well defined with a central scar
On arterial phase there is centrifugal filling (opposite to haemangioma/adenoma)
On portal venous phase the lesion will be isointense to background liver
Central scar can be high on T2 and can enhance on delayed scans
What are the imaging features of a hepatic haemangioma?
Bright on ultrasound with no internal doppler signal
CT/MRI : peripheral discontinuous nodular enhancement with progressive filling in
T2 bright
Patient with massively dilated hepatic artery and multiple AVMs in liver and lungs.
Diagnosis?
Hereditary haemorrhagic telangiectasia
(Osler-Weber-Rendu syndrome)
What are the MRI characteristics of regenerative hepatic nodules?
T1 & T2 dark with no enhancement
What are the MRI features of dysplastic hepatic nodules?
T2 dark, T1 bright, usually no enhancement.
What are the prehepatic, hepatic and post-hepatic causes of portal hypertension?
Pre-hepatic : portal vein thrombosis, tumour compression
Hepatic : cirrhosis, schistosomiasis
Post-hepatic : Budd-Chiari
What is McKittrick-Wheelock syndrome?
Villous adenoma which causes a mucous diarrhoea leading to severe fluid and electrolyte depletion.
Cowdry type A intranuclear inclusion bodies can be seen on pathology in which colitis?
Colonic CMV
What are the ultrasound features of an appendix mucocele?
Layering within a cystic mass “onion sign”.
What are the common associations with ulcerative colitis?
Primary sclerosing cholangitis
Ankylosing spondylitis
Colorectal carcinoma
Moyamoya phenomenon.