Cardiothoracic Flashcards
What are the imaging features of sarcoidosis?
Bilateral hila + right paratracheal lymph nodes
Perilymphatic nodules with upper lobe predominance
Late : upper lobe fibrosis + traction bronchiectasis
What are the causes of right heart failure?
Left heart failure (most common)
Chronic PE
Right-sided valve issues (tricuspid regurgitation)
Interstitial lung disease related to smoking with poorly defined apical centrilobular nodules
Respiratory bronchiolitis-interstitial lung disease
(RB-ILD)
What is the most common interstitial lung disease in scleroderma?
Non-specific interstitial penumonia
(NSIP)
Interstitial lung disease with lower lobe, peripheral predominance and sparing of the immediate subpleural lung.
Non-specific interstitial pneumonia
(NSIP)
What is the differential for perilymphatic pulmonary nodules?
Sarcoidosis (90%)
Silicosis
Lymphangitic spread of cancer
How can you differentiate between cancer and progressive massive fibrosis on MRI?
Cancer = T2 bright
PMF = T2 dark
Silicosis increases your risk of which infection?
TB
(by 3-fold)
Which type of emphysema is seen in alpha-1-antitrypsin deficiency?
Panlobular with lower zone predominance
Which of the following options is negative on thallium201 scan?
- Kaposi 2. Lymphoma 3. PCP
- PCP
Which of the following options is negative on gallium67 scan?
- Kaposi 2. Lymphoma 3. PCP
- Kaposi
Which of the following options is positive on both gallium67 and thallium201 scan?
- Kaposi 2. Lymphoma 3. PCP
- Lymphoma
Lymphocytic interstitial pneumonitis (LIP) is associated with which conditions?
Sjogren’s (most common)
HIV ← answer if in a child
SLE
RA
Castleman
Birt Hogg Dube cystic lung disease has what kind of cysts?
Thin-walled oval cysts
Lymphangiomyomatosis (LAM) is associated with which kind of pleural effusions?
Chylous
What is the most common cardiac manifestation of tuberous sclerosis?
Rhabdomyoma
Lymphangiomyomatosis (LAM) is associated with which phakomatosis?
Tuberous sclerosis
What are the patient and radiology characteristics of Langerhan’s cell histiocytosis (LCH)?
Smokers aged 20-30
Centrilobular nodules with upper lobe predominance which cavitate into cysts
Which conditions classically spare the costophrenic angles?
Langerhans cell histiocytosis (LCH)
Hypersensitivity pneumonitis
Extralobar sequestration is associated with which other anomalies?
Congenital cystic adenomatoid malformation (CCAM)
Congenital diaphragmatic hernia
Vertebral anomalies
Congenital heart disease
Pulmonary hypoplasia
Which lung segment is most common segment for intralobar pulmonary sequestration?
Posterior segment of the left lower lobe
Which condition, intralobar or extralobar sequestration, presents in adolescence or adulthood with recurrent pneumonia?
Intralobar
Which condition, intralobar or extralobar sequestration presents in infancy with respiratory compromise?
Extralobar
Poland syndrome results in aplasia/hypoplasia of pec major (most common), pec minor, 2-5th ribs and breast/nipple. What other associations are there?
Upper limb abnormalities (small hand + brachysyndactyly, simian crease)
Where does a persistent left SVC normally drain?
Coronary sinus
What syndrome is associated with pulmonary arteriovenous malformations (AVM)?
Hereditary haemorrhagic telangiectasia
(Osler-Weber-Rendu syndrome)
Which lung segment is most commonly involved in bronchial atresia?
Apical-posterior segment of the left upper lobe
AIDs patient with lung nodules, pleural effusion and lymphadenopathy. What is the most likely diagnosis?
Lymphoma
(almost exclusively high grade NHL, CD4 < 100)
Carcinoid heart disease can occur in which cancers without liver metastases?
Bronchial carcinoid tumour
Ovarian carcinoid tumour
What scan can be carried out to localise a carcinoid tumour?
Octreotide scan
Which cardiac valves can be affected in GI carcinoid syndrome?
Tricuspid & pulmonary
Which cancers can cause the classic “cannonball” metastases?
Renal cell
Choriocarcinoma (testicle)
Which cancers cause lymphangitic calcinomatosis?
Bronchogenic (most common)
Breast
Stomach
Pancreas
Prostate
What is the bacterium responsible in the majority of cases of Lemierre syndrome?
Fusobacterium necrophorum
What is the syndrome characterised by seropositive rheumatoid arthritis and pulmonary fibrosis?
Caplan syndrome
Fungal infection with invasion of the mediastinum, pleura & chest wall?
Mucormycosis
What are the 6 major criteria for ABPA?
Asthma
Central bronchiectasis
Pulmonary opacities (transient or chronic)
Blood eosinophilia
Skin reactivity to Aspergillus antigen
Increase serum IgE
What is the treatment for immune reconstitution inflammatory syndrome?
Steroids
What are the risk factors for immune reconstitution inflammatory syndrome?
Low CD4 count (< 50)
High plasma HIV RNA (before therapy)
Rapid decrease in CD4 count of HIV RNA following initiation of therapy
Initiation of HAART soon after diagnosis. of an opportunistic infection (TB, PML, cryptococcus, Kaposi)
A patient with AIDs is started on antiretroviral therapy. 1 month later they have worsening symptoms despite improvements in CD4 counts and falling viral load. What is the diagnosis?
Immune reconstitution inflammatory syndrome
(IRIS)
An aneurysm in the context of a TB cavity is called what?
Rasmussen aneurysm
What are the 2 main differentials for hypervascular lymph nodes in AIDs patients?
Kaposi sarcoma
Castleman disease
AIDs patient with lung cysts, ground glass opacification and pneumothorax. What is the likely diagnosis?
PCP
What is the most likely diagnosis in a patient with AIDs and “flame-shaped” perihilar opacification?
Kaposi sarcoma
Ground glass opacification in a patient with AIDs. What is the most likely diagnosis?
PCP
(could be CMV if PCP not an option and CD4 < 100)
What is the most common cause of pneumonia in AIDs patients?
Strep. penumoniae
Pneumonia following dental procedure with osteomyelitis/chest wall invasion?
Actinomycosis
Bacterial pneumonia common in patients in ICU on ventilator, CF and primary ciliary dyskinesia?
Pseudomonas
Bacterial pneumonia which causes “currant jelly sputum”?
Klebsiella
An aberrant right subclavian artery will cause obliteration of what on a lateral CXR?
Retrotracheal triangle aka Raider triangle
What are the imaging features of proximal interruption of the pulmonary artery?
Only one pulmonary artery
Absence of the PA on the opposite side of the aortic arch
Volume loss of one hemithorax
What is proximal interruption of the pulmonary artery associated with?
Patent ductus arteriosus.
Interrupted left pulmonary artery associated with tetralogy of Fallot + truncus arteriosus.
Thymoma is associated with what?
Myasthenia gravis
Pure red cell aplasia
Hypogammaglobinemia
Empyema necessitans, where an empyema invades into chest wall and soft tissues is classically caused by what?
TB (70%)
Actinomyces is 2nd most common
“Shrinking lung” is associated with which condition?
SLE
(most common chest manifestation is pleuritis with/without effusion)
Which syndrome is characterised by primary ciliary dyskinesia and situs inversus?
Kartagener syndrome
What are the features of primary ciliary dyskinesia?
Chronic sinusitis
Conductive hearing loss
Bilateral lower lobe bronchiectasis
50% have Kartagener’s syndrome
Impaired fertility
Irregular focal/short segment thickening of trachea/main bronchi with calcification. What is the most likely diagnosis?
Amyloidosis
Circumferential thickening of the trachea with no calcification C-ANCA positive.
What is the most likely diagnosis?
Granulomatosis with polyangiitis
(Wegener’s)
Diffuse thickening of the trachea with sparing the posterior membrane and no calcification.
What is the most likely diagnosis?
Relapsing polychondritis
Cartilaginous and osseous nodules within the submucosa of the trachea and bronchial walls with sparing of the posterior membrane.
What is the most likely diagnosis?
Tracheobronchopathia osteochondroplastica
“Headcheese” is used to describe the imaging feature of which condition?
Chronic hypersensitivity pneumonitis
(Describes GGO, consolidation, air trapping and normal lungs)
What are the causes of cryptogenic organising pneumonia (COP)?
Idiopathic
Infection
Drugs (amiodarone)
Collagen vascular disease
Fumes
What are the imaging features of cryptogenic organising pneumonia?
Patchy airspace or GGO in a peripheral or peri-bronchial distribution
Reverse halo/ atoll sign
Patients with pulmonary alveolar proteinosis are at increased risk of what infection?
Nocardia
What are the CT findings of chronic rejection (bronchiolitis obliterans syndrome) following lung transplant?
Air trapping
Bronchiectasis
Bronchial wall thickening
Interlobular septal thickening
What is the most common opportunistic infection following lung transplant?
CMV
(2-4 months after transplant)
What is the imaging features of acute rejection following lung transplant?
Ground glass opacities and intralobular septal thickening.
(No ground glass → no rejection)
Hot quadrate sign is seen in what pathology?
SVC obstruction
What are the 3 main causes of pulmonary artery aneurysms?
Iatrogenic from swan ganz catheter
Behcet’s (also have mouth/genital ulcers)
Chronic PE
What are the causes of fibrosing mediastinitis (soft tissue mass with calcifications infiltrating fat planes)?
Idiopathic
Histoplasmosis
TB
Radiation
Sarcoid
A calcified papillary muscle, seen on prenatal ultrasound as an echogenic focus in the left ventricle and usually goes away by the third trimester is associated with an increased incidence of what?
Down’s syndrome
What is the difference between lipomatous hypertrophy of the intra-atrial septum and a lipoma?
Lipomatous hypertrophy spares the fossa ovalis creating a “dumbbell appearance”
It can also be hot on PETCT because it is often made of brown fat
What are the branches of the left main coronary artery?
Circumflex (divides into obtuse marginals which supply lateral margin)
Left anterior descending (divides into septal branches and diagonals)
What are the branches of the right main coronary artery?
Acute marginal
AV node branch
Posterior descending artery (in most people)
What is meant by malignant origin of the left coronary artery?
When the LCA arises from the right coronary sinus and courses between the aorta and pulmonary artery
This can get compressed and lead to sudden cardiac death.
Reversal of flow in the left coronary artery as the pressure decreases in the pulmonary circulation, termed STEAL syndrome, is caused by what?
Anomalous left coronary artery from the pulmonary artery (ALCAPA)
What are the causes of coronary artery aneurysms?
Atherosclerosis (most common cause in adults)
Kawasaki (most common in children)
Iatrogenic
Velocity encoded CINE MR imaging/ velocity mapping/ phase contrast imaging is an MR technique for what?
Quantifying the velocity of flowing blood
What is the most common congenital heart disease?
Bicuspid aortic valve
(if not an option chose VSD)
What is the differential for aortic stenosis?
Atherosclerosis (degenerative)
William’s syndrome
Rheumatic heart disease
Bicuspid aortic valve
Williams syndrome is characterised by what features?
Craniofacial dysmorphism
Short stature
Intellectual disability
Supravalvular aortic stenosis
Pulmonary artery stenosis
Renal artery stenosis
Hypercalcaemia
What is the most common associated defect with aortic coarctation?
Bicuspid aortic valve
What are the associations with a bicuspid aortic valve?
Dilatation of the ascending aorta (most frequent)
Congenital heart diseases (ASD/VSD, PDA, hypoplastic left heart, coarctation)
Turner syndrome
Cystic medial necrosis
Autosomal dominant polycystic kidney disease
Intracranial aneurysm
What are the causes of aortic regurgitation?
Aortic root dilatation (HTN/ Marfans)
Aortic dissection
Bicuspid aortic valve
Bacterial endocarditis
What is the most common cause of mitral stenosis?
Rheumatic heart disease
What are the imaging features of mitral stenosis?
Left atrial enlargement
(double density sign, splaying of the carina, posterior oesophageal displacement)
Isolated right upper lobe pulmonary oedema is associated with what?
Mitral regurgitation
What are the causes of acute mitral regurgitation?
Myocardial infarction with papillary muscle rupture (most commonly posteromedial papillary muscle)
Infective endocarditis
Chordae tendinae rupture in myxomatous degeneration
What are the causes of chronic mitral regurgitation?
Annular calcification
Myxomatous degeneration
Previous infective/ inflammatory illness
Dilated cardiomyopathy
Hypertrophic obstructive cardiomyopathy
What are the causes of pulmonary stenosis?
Noonan syndrome
Williams syndrome
Tetralogy of Fallot
What are the features of Alagille syndrome?
Paucity/ stenosis of the intrahepatic biliary ducts
Renal anomalies (cystic kidney disease, small kidneys, nephrocalcinosis)
Hypoplasia of the posterior semicircular canal
Butterfly vertebrae
Coarctation of the aorta
Peripheral pulmonary artery stenosis
Peripheral pulmonary artery stenosis can be seen in what syndrome?
Alagille syndrome
What are the causes of pulmonary regurgitation?
Congenital valve disease repair (TOF)
Pulmonary arterial hypertension