Gastro medications Flashcards
What do give to treat ulcerative colitis Crohn’s disease, and other types of inflammatory bowel disease
Sulfasalazine
Prolonged treatment with PPIs can cause…
Hypomagnesaemia
Hypomagnesaemia can present with similar symptoms to …
Hypocalcaemia
PPI and a treatment with NSAIDs… could result with
NSAID induced ulcers
PPI increase the risk of c.difficile true or false?
true
Side effects of Mesalazine?
Mesalazine > sulfasalazine in terms of pancreatitis risk
How do Proton Pump Inhibitors work?
Proton pump inhibitors (PPI) cause irreversible blockade of H+/K+ ATPase of the gastric parietal cell.
What are the adverse effects of PPI?
hyponatraemia
hypomagnasaemia
osteoporosis → increased risk of fractures
microscopic colitis
increased risk of C. difficile infections
Examples of PPI?
Omeprazole, Lansoprazole
How do H2 Receptor Antagonists work?
H2 receptor antagonists are a group of medications that block histamine (H2) receptors.
They competitively inhibit histamine in H2 receptors of parietal cells, suppressing the normal secretion of stomach acid from parietal cells.
Ranitidine blocks histamine H2 receptors on which cells in the stomach?
Parietal Cells
What does the H stand for in H2 Receptor?
Histamine
Side Effects of H2 Receptor Antagonists
Hypotension
Headache
Tiredness
Dizziness
Confusion
Constipation
Diarrhoea
Rarer but more serious side effects are agranulocytosis, alopecia, arthralgia and pancytopaenia
Caution and Contraindication of H2 Receptor Antagonists
Use with caution in patients at risk of gastric cancer.
How does Metoclopramide work?
Metoclopramide works through antagonism of the D2 dopamine Receptors
